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Vaccine 90 percent effective

hopeful and opt...
Posts: 2306
Joined: Apr 2009

Great news today. The best since February. I am celebrating. Pfizer's vaccine is 90 percent effective. The other vaccine making companies are using the same ingredients. Stay safe for the next few months.

I am celebrating 

 

Old Salt
Posts: 790
Joined: Aug 2014

At least one other company is pursuing the same (mRNA) technology.

But there are other approaches in development as well.

Max Former Hodgkins Stage 3's picture
Max Former Hodg...
Posts: 3613
Joined: May 2012

Many people were saying that COVID "would end as a problem in the US on November 3."   They were laughed at.    It took a week longer than they predicted......

 

Note:  a virus vaccine that is 75% effective is regarded as hugely successful

 

Georges Calvez
Posts: 503
Joined: Sep 2018

Hi there,

There are still immense logistical problems to overcome.
The vaccine has to be stored at dry ice temperatures which requires thermal shock resistant vials on an immense scale as you need two shots per person.
It also has to be transported in insulated containers packed with dry ice, we do not remotely have sufficient manufacturing facilities for this.
Transporting the vaccine to remote areas / getting people to vaccination stations will require a lot of effort.
Densely populated areas like cities will be fairly easy, low density rural areas will be a different ball game.
If people have to be regularly revaccinated then the problems will multiply.
The UK reckons they can vacccinate 10 million before Christmas and maybe 20 million in the first quarter next year, that is only 60 million injections to schedule and carry out in what is a small and densely populated island with a pretty efficient state controlled national health system.
Other places are a lot harder, I am calling it qualified good news for the moment.

Best wishes,

Georges

VascodaGama's picture
VascodaGama
Posts: 3320
Joined: Nov 2010

I wonder how they measure the efficacy of the vaccines. Pfizer, Moderna and AstraZeneca who produces the so called mRNA-vaccines, claimed that theirs were 90% effective in accordance to the results from the short clinical trials, but I think that the reference regards the side effects from the vaccination which were considered as safe. Efficacy in combating the bug can only be substantiated if the trials involved injecting the live virus on the participants. Using nurses or people treating covid patients or belonging to the combat’s front line is not enough. I believe that efficacy will only be confirmed in one year time since inoculation, and that should include the results on those identified with the sars-cov2 variants. In fact, these mRNA vaccines using part of the genetic material of the virus to create T- or B-lymphocytes may not be adequate to all the variants. More time is needed to be certain that the present vaccines are the solution to Covid-19.

In another thread Grinder informed about the (Eli) Lilly vaccine which is produced with a deactivated sars-cov2. The purpose is to educate the immune system in recognizing it as foreigner, leading to an attack on the bug. This principle is similar to the common type of vaccines used around the world to combat the seasonal cold. However, sars-cov2 shows to be better prepared for invasion of lung cells than other virus as its protein “spike” got better affinity to cause infection at this vital and delicate organ. Once in the cell it goes through mutations becoming more intelligent at each time leading to variants that can be thought as new novel coronavirus (nCoV) that are not yet identified by the immune system. This type of vaccine would require being adaptable to each mutation to show efficacy.

In this regard I believe that the advanced Eli Lilly drug to treat infection (commented by our fella Grinder) is a better option. This is a monoclonal antibody (mAB) working similarly to the ones in use to treat cancer that we have spoken in previous threads regarding the clinical trials on mabs for PCa. Eli Lilly drug (Bamlanivimab) as passed some clinical trials and have been approved to fight Covid-19. MABs act as stealth missiles. They aim the bug’s “spike” wherever it lies; lungs, heart, nerves, brain, vessels, kidneys and skin.

In my lay opinion, the immune system doesn't kill the virus but it kills those cells that have been infected by the virus, eliminating the malady for good. The effects caused by the action of the immune system in the lungs can be so destructive to the extent of causing permanent scars affecting the patient for life. The long-haulers as they are known now. Too much intervention by the immune system can cause "cytokine release syndrome" which can be fatal in serious cases.

Merry Christmas and a Happy New Year | Cancer Survivors Network

Let’s be careful to avoid bringing the virus into our homes or contracting it.

Best wishes to all.

VGama

lighterwood67's picture
lighterwood67
Posts: 285
Joined: Feb 2018

Always good to read about these vaccines.  However, for now, I am sticking with the short guy, Dr Fauci and of course current guidance.  Take care.  

Grinder
Posts: 472
Joined: Mar 2017

Vascodagama... It seems the antibody treatment, which I agree would be a preferred treatment for positive Covid cases, is not being used as a first line of defense here in the States. 

Since I cannot comment on the political atmosphere here in a partisan way according to forum guidelines, suffice it to say that politics is driving the Covid response whether by the Lilly antibody med, the Pfizer and Moderna vaccines, Remdesivir, Hydroxychloroquine, competing vaccines that have been quashed, etc.

The media has the public so confused because of their own partisanship, no one knows what is true or what is not. Anecdotal evidence we witness often contradicts media reporting on politics and Covid information. 

And if you haven't heard, social media giants are in a massive campaign to eliminate dissenting voices.

At this point, I cannot say anything regarding Covid vaccines and treatments to be true or not. Covid is a political football being kicked back and forth and used as a cause celebre to push political agendas here in the States. 

Any information everyone in this forum relays from outside regarding covid is greatly appreciated.

Grinder
Posts: 472
Joined: Mar 2017

Not long after I opined on the various treatments above... lo and behold Hydroxychloroquine is being given renewed interest as an effective treatment for early onset symptoms in various medical journals.

Who knew?

hopeful and opt...
Posts: 2306
Joined: Apr 2009

Agree, thank G-d for Dr Fauci, who although short in stature is heads above the rest of with scientific based comments. Also THANK YOU to the scientists ,doctors, statisticians and others who developed these vaccines. 

Grinder
Posts: 472
Joined: Mar 2017

This is an example of the confusion here regarding vaccines as well as positive case numbers:

****************************

Medical experts say the bottleneck could be loosened if the Food and Drug Administration approved Oxford-AstraZeneca, a vaccine developed by Oxford researchers that is more affordable than other vaccines currently available and far easier to distribute.

“The FDA needs to stop playing games and authorize the Oxford-AstraZeneca vaccine. It’s safe, cheap ($2-$3 a dose), and is the easiest vaccine to distribute,” says Dr. Marty Makary, a professor of surgery and health policy at the Johns Hopkins University School of Medicine. “It does not require freezing and is already approved and being administered in the United Kingdom.”

Others agreed.

Economist Alex Tabarrok pointed out that AstraZeneca’s coronavirus vaccine is being produced at a Baltimore plantright now, and is capable of producing tens to hundreds of millions of doses annually.

hopeful and opt...
Posts: 2306
Joined: Apr 2009

  • In the UK, vaccines Pfizer, Moderna, and AstraZeneca are being used to fight the pandemic. AstraZeneca's hasn't been approved for use yet in the US.
  • AstraZeneca may not apply for a US FDA Emergency Use Authorization until the spring. The data from their UK trial was "odd" and had one "pretty serious error" in it, a US vaccine expert said. 
  • AstraZeneca is now conducting a larger trial of nearly 30,000 people in the US. 
ASAdvocate
Posts: 153
Joined: Apr 2017

I was reading two days ago that clinical trials are having difficulty

recruiting people, and alternative methods of validation may be needed.

This is because prospective enrollees are preferring to get one of the available vaccines rather than enter a trial, and take the chance of getting a placebo.

Georges Calvez
Posts: 503
Joined: Sep 2018

Hi there,

I am waiting to see what happens three or four weeks after 60 - 70 % of the population is vaccinated, in theory there should be a drastic decline in the number of cases.
The UK has done a high proportion of the 80+ population and is working on the 70+ part of the population now, now up to 9.8% of the total adult population vaccinated.
As these are the high risk groups the line should start to fall soon.
France is a long way behind, so we are still sitting it out, I am waiting for that cold glass of cider in the Café Le Finistère in the summer, but I might have to have it in the garden at home.

Best wishes,

Georges

Max Former Hodgkins Stage 3's picture
Max Former Hodg...
Posts: 3613
Joined: May 2012

I got Dose 1 of the Pfizer vaccine yesterday.  Zero side effects one day later.  I am auto-immune compromised  over ten years now, due to lymphoma and chemo, and also have lymphadenopathy due to a diagnosed immunological disease, so me having no side-effects is somewhat interesting.   My state of SC has only around 5.3 million people, but around 1.5 million have been vaccinated with at least Round 1, which is very roughly 30%.   (One lone hospital in Charleston has administerd 150,000 doses itself.)  Positive Covid test results are at about 3.4% statewide.   Two months ago, we were at over 20%, one of the highest in the nation.   

Total deaths in this state, as of two days ago, is almost exactly 9,000.  Out of 5,300,000.   Statistically, zero % were patients under 50; perhaps 25 individuals.  The sky is not falling.  Bless France, the land of the best wines,

max

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VascodaGama
Posts: 3320
Joined: Nov 2010

Georges,

I was dawn on your comment in "...  three or four weeks after 60 - 70 % of the population is vaccinated  ...". Do you really believe that such percentages are achievable in one month? The pharmas do not stock pile enough quantities even to vaccinate just 30% of the EU population within this year.

According to the pharmas, in a two shot vaccine, the protection by the First Shot starts at about the 10th day and it only shows about 50% of effectiveness which requires a booster second shot to improve the effectiveness to close to 90%. The Second Shot is done 21 to 28 days apart but it may show still some considerable effectiveness if this period is extended up to 45 days. This means that the double shot is unavoidable to achieve the purposes; however, when we look on the issue globally we find that it will take over ten years to inoculate the world population for the success against Covid-19.

Israel that managed to get a high volume of vaccines, ahead of any other country of the world, in an obscure manner, may provide a clue about the efficacy of the Pfizer vaccine now that they have about 30% of vaccinated population, but still doubtful as they check effectiveness by the symptoms in each vaccinated person. They do not test to confirm inoculation.

Unless someone finds a drug that provides cure, I believe that sars-cov2 is to stay and that, even those that got the double vaccine, will require an annual boost similar to those that get the common shot for other coronavirus. This kind of boosting system will be hardly achievable worldwide in a time scale appropriate if more resources are not facilitated in the world.

Sorry for my above opinion.

Best,

VG

Georges Calvez
Posts: 503
Joined: Sep 2018

Hi Vasco,

We have a misunderstanding here.
I am talking about three to four weeks AFTER the target of 60-70% of the population has been achieved.
This will allow the vaccine to produce an effective level of antibodies and confer whatever resistance it is capable of achieving.
The UK has done 9.8% so far, I reckon they will get up to that kind of percentage by the late spring /early summer if they increase their rate which looks likely, end of June at the latest.
Israel is certainly interesting, they have a high vaccination rate so that it should start to impact the transmission and hospitalisation rate if the vaccine is effective.
I have my doubts about finding a drug quickly, all the likely candidates must have been tried by now.
Certainly living with COVID-19 is on the cards for some time, but for how long and the difficulty of doing so is still very difficult to determine.

Best wishes,

Georges

Georges Calvez
Posts: 503
Joined: Sep 2018

Hi there,

This seems to indicate that a high rate of vaccination will control the epidemic, at least at the moment.
However producing enough vaccine and carrying out worldwide vaccination is a herculean task.
The article was taken from the Guardian.

Best wishes,

Georges

No serious Covid cases among those receiving both Pfizer jabs in Israel, minister says

 

Health minister Yuli Edelstein told a parliamentary panel that new infections and hospital admissions for serious or critical Covid-19 complications were now at record numbers. But he said he knew of “no serious morbidity” among Israelis eligible for the vaccination certificate – a document issued by the state a week after the second dose is administered, when Pfizer says the vaccine is 95% effective.

He said 0.014% had contracted milder forms of Covid-19. According to health ministry figures, 23% have received the first shot and more than 6% the second, between 21 and 28 days later. A week after beginning vaccinations, it imposed its third national lockdown, which officials say may need to be extended into February.

But last Thursday it reported a reproduction number - known as R - of less than 1, which indicates that epidemic is no longer growing.

 

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VascodaGama
Posts: 3320
Joined: Nov 2010

Georges,

Thanks for the article. It seems that Israel 's vaccination program is advancing well in just 30 days since starting. Lets wait to see the results in one month time.

Portugal started the vaccination one week later (Dec 27) but as of today it has only accomplished 3 persons per 100 whereas Israel have already done 45 persons per 100. Both programs are similar,  vaccinating firstly the medical community and older people in care homes. I wonder if the numbers in death by covid have been lowered due to the fast vaccination program. 

Portugal become the worse European country with the highest daily number in newer cases (>1,000/million) and number of death (23/million). Some hospitals have reached rupture. The number of cases are expected to rise even if the present confinement is extended for more two weeks. The minister of health has announced that they might looking for help in other countries where to send covid patients.

Grim situation. 

Best 

VG

 

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VascodaGama
Posts: 3320
Joined: Nov 2010

Hi again, 

Israel TV announced today in an interim report that 100 people from 130,000 with two shots of the Pfizer vaccine have contracted the virus. I would think that these patients unfortunately belong to the 10% group that were found from the trial as not beneficiaries. 

However, additional information regarding the cause of contraction is not provided yet, which makes me think that these positive cases occurred just at the time when the second shot was administered at the 21st to the 28th day or before it, because symptoms of infection is typically shown 10 to 15 days later. They started the shots on December 20th (38 days ago).

EU is approving today the Astra-Zeneca vaccine for uses in people aged 16 to 65 years old so that I am disqualified for the shot. I wonder why but it could relate to the flawed data in UK's trials commented by Hopeful above. 

Let's cross our fingers for good news on the results. 

VG

Grinder
Posts: 472
Joined: Mar 2017

Well gentlemen...

It looks like Lilly is back to developing an alternative to the messenger RNA vaccines, instead using antibodies as a preventative. They already have developed and employed an antibody treatment for patients with advancing symptoms of Covid, and now they are conducting trials for an antibody as a preventative to contracting Covid.

And GUESS WHO MAY VERY WELL BE A TEST SUBJECT...

THIS GUY!

Physicians Research Group is conducting trials in Georgia, Arizona and here in central Indiana. The trial lasts about a year... begins with and interview and health screening. If I pass muster, then I will get the antibody injection on the next visit, then have 7 more visits over the year, and phone contact monitoring my health for side effects and also potential exposure to Covid during the year of monitoring.

According to the researchers that spoke with me, this preventative antibody treatment will have advantages in that it is only one shot in the hip and it won't require special temperature storage. 

I am excited and hoping I can get past the screening so I can be part of medical history. Of course it is all altruistic motives for my participation. The money doesn't have anything to do with it.   ;D and yes, I will get paid.  :D

 

Assuming I pass the screening, I will keep you guys abreast of my progress. 

hopeful and opt...
Posts: 2306
Joined: Apr 2009

Grinder

In my eyes, you are a hero..........THANK YOU

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VascodaGama
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Joined: Nov 2010

Yes,  Grinder, I cross my fingers that your wish becomes true and that you are accepted into the trial. I am looking forward to read your reports and details on how everything is done, and most importantly about the success. 

Mabs therapies are the means for fighting disease using the body defenses to reach and eliminate the malady. The mRNA vaccines are the future ways in prevention of infections. These too aims in avoiding contraction of diseases. It all come to reality from the successful researching works of the Nobel prize winners in medicine,  Dr James Allison and Dr Tasuku Honjo.

They are not the only ones to be applauded because the researches involved many fields in medicine but their work was put into action and had successful results. Bio-markers, cell's chemistry and nano-medicine are involved. It is all so fascinating. 

Let’s celebrate. I raise a glass of my favorite red wine. 

Best wishes, 

Vgama 

 

Grinder
Posts: 472
Joined: Mar 2017

Hi guys...

An update. Waiting game now. Btw thanks for the sentiment but you are being way too nice. 

This is not a Lilly study after all but is an AstraZeneca application of the Lilly antibody treatment but as a preventative measure instead of treatment for symptoms.

Physician's Research Group is conducting a pair of clinical trials focused on the prevention of COVID-19. These studies use monoclonal antibody therapy, which serves as a medication alternative to the vaccine for those who seek additional options

I sent my medical history and now its a waiting game to see if my medical profile matches a group profile they are seeking for this research. I do know they are especially seeking over 60s for this study... Whether or not a Prostate Cancer survivor fits their desired profile is yet to be determined. 

If my medical profile matches, I will be brought in for screening, and I will bring the consent forms with me. 

After the screening, if I pass the screening, they will test for covid several times throughout, will get two shots of the antibody treatment in my buttcheek, will have blood draws then and during 7 more visits, plus constant health monitorung and other tests.

When I was an intern at the Psychiatric Research Center as a grad and undergrad, running neurochemical experiments on behavior in rats and pigeons for the researchers, I did not know the tables would turn, and I would someday be the lab rat getting the injections and being observed. 

Turns out, this preventative measure is for demographics that cannot take the messengerRNA vaccine... But the drawback is that it is estimated to last only up to 6 months before needing a booster. So it is not a magic bullet necessarily.

eonore
Posts: 103
Joined: Jun 2017

Many thanks for volunteering and putting yourself on the front lines.  I hope you get picked and help make the coronavirus a mere nuisance.

 

Eric

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VascodaGama
Posts: 3320
Joined: Nov 2010

Yes, you continue to be our hero in spite of the difference of the clinical trial. I hope you benefit from the mab's shot. Meanwhile the efficacy of some of the vaccines discussed above have run into questionable doubts if they are proper to everyone or every variant of the virus.

In UK they are now thinking in the means to distinguish/qualify those who have been vaccinated from those who have not. Visitors to the country or returnees without a vaccine-passport may not be welcomed. I think that the problem raised from the high number of people willing to abstain from being vaccinated. The same situation is seen in Israeli where 1/3 of the population have been vaccinated but where it has been difficult to fulfill the daily list of people for the vaccine. Lesser numbers are now registered and the vaccines are accumulating in storage.

Immunization of the country is not expected if 70% of the population is not inoculated. Governments are looking for means to allure people for the vaccine even if that must be forcible. Some countries oblige vaccination to all but some allow defiance. I wonder what kind of law they are going to cook up to deny the right to don't vaccinate in the EU.

I am more tempted to get a mab-shot than a vaccine but mabs in Europe may be seen only after men has put foot on Mars. 

Best

VG 

 

Grinder
Posts: 472
Joined: Mar 2017

I'll tell you guys what I told my wife...

Do you really want to inflate my ego any bigger than it already is?

She said HECK NO!

LoL 😂😂😂

Grinder
Posts: 472
Joined: Mar 2017

Here is the title of the research program:

"A Phase III Randomized, Double-blind, Placebo-controlled, Multi-center Study in Adults to Determine the Safety and Efficacy of AZD7442, a Combination Product of Two Monoclonal Antibodies (AZD8895 and AZD1061), for Pre-exposure Prophylaxis of COVID-19."

 

 Seriously, that is just the title.

I went in this morning where some very nice staff nurses tooks my vitals, urine sample, nasal swab for Covid test (ugh), another test for covid antibodies, an EKG, check over by the doctor, and blood draw of six vials of blood (!).

Then the doc shot me in the buttcheeks... Two injections, one in each side. 

Then I had to wait around another hour while they observed me to make sure I didnt grow a second head or other dramatic side effect... Then I went home.

Now they will be calling me during the week and I will be going back every week so they can monitor my progress and draw more blood to monitor progress of antibodies.This monitoring will be going on for a couple months and the study itself lasts for half a year.

So there it is. I felt NO unpleasant side effects at all. And they daid no one has reported any so far.

The purpose of this preventative treatment will be for persons who cannot take the other vaccines for whatever reason. The only drawback is it has to be renewed occasionally every six months to a year. It is not a one and done like vaccines are normally. 

Grinder
Posts: 472
Joined: Mar 2017

Just kidding

 

 

 

 

(Just kidding)

Max Former Hodgkins Stage 3's picture
Max Former Hodg...
Posts: 3613
Joined: May 2012

A also am fine, following my first injection yesterday.   But my wife says I make ultrasonic bat noises in my sleep.

 

.

Old Salt
Posts: 790
Joined: Aug 2014

is a well-known side effect of monoclonal antibody therapies; watch out for those. Wink

No, seriously; this is a very interesting study. and we are grateful to you for keeping us updated.

VascodaGama's picture
VascodaGama
Posts: 3320
Joined: Nov 2010

Grinder the Hero, 

Yes, you describe all in doubles so you may get effects in double too. Lol

This ADZ7442 has been given to covid patients in phase 2 showing reliability in the cure. In this phase 3 (your timing) they will check its capabilities in prevention and treating. All those tests done before the injection is to group you in the prevention or treatment cohort in case you are negative or positive to the virus. 

I wonder if they give you the blood test results. It would be good if you retain a copy to compare the markers at the six months milestone. 

The good things in clinical trials is the constant attention provided by the professionals. We couldn’t be safer. 

Here are details on the trial:

https://www.precisionvaccinations.com/vaccines/covid-19-antibody-azd7442

The EU population were set to receive the Astra-Zeneca AZD1222 vaccine used in the UK but due to manufacturers restrains some countries started to use other vaccines from different pharmas which I believe that they get to identical outcomes as these work similarly in terms of prevention. EU officials that have politicized the vaccination program are now in war against Astra-Zeneca’s default insisting them to deliver the contracted numbers the soonest. It would be nice if Astra-Zeneca instead delivers the AZD7442.

The AZD1222 is a sort of flu vaccine known as “adenovirus vaccine" which uses a virus studied and in use for many years in similar vaccines. This virus is altered to carry a gene for sars-cov2 protein that, in time, will then educate our immune system to recognize the bandit.

I wonder why was the shot done at the buttocks?

Thanks for the update.

VGama

 

Georges Calvez
Posts: 503
Joined: Sep 2018

Hi everybody,

The vaccine is not looking like a one and done shot either.
Already the UK is talking about a booster in the autumn to cover new strains, etc.
We could end up with an annual vaccination campaign every autumn similar to the flu, maybe in combination with the flu vaccine.
This will probably be manageable in the US, Canada, most of Europe, Japan, China, India, etc, but I doubt it will be possible worldwide.
On the bright side spring is on its way in Northern France!

Best wishes,

Georges

Grinder
Posts: 472
Joined: Mar 2017

Not much to comment on this update. The first follow up visit was checking vital signs and looking for side effects. As far as I can tell everything is tip top.

Instead of going back every week, there looks like a 2-3 week lull between visits. So this study stretches the visits out longer than what I thought... as long as there are no health complications of any sort.

Vasco... you are right, they take good care and are very conscientious. And if I contract Covid during the study for any reason, even if the transmission has nothing to do with the study participation, they will provide the best care available at the best facility available with the best professionals available, all paid for by AstraZeneca at no cost to me or my insurance.

After hearing about the study from me, several friends have notified relatives, who cannot take the vaccine for a variety of reasons, that this preventative treatment will hopefully be available next year. I don't know if the wheels of research can move that quickly, but I am hoping they will. I will ask at the next visit when is the earliest they can project, assuming all goes as planned, which it seems to be doing. 

Grinder
Posts: 472
Joined: Mar 2017

Well you know what they say, Old Salt...

"Two heads are better than one"...

So maybe that's not such a bad side effect after all. As long as the new head realizes I am the "a priori" head, and I get to eat the junk food and he has to take the medicines. And I do all the talking. And I get to kiss my wife. And I decide what we watch on TV. And what books we read. 

But I'll let him do all the driving while I nap. 😀

GeorgeG
Posts: 152
Joined: May 2017

Does anyone have any data or perspective on any of the vaccine types and its compatibility with active PC and/or ADT/Firmagon? I am trying to decide if I am going to get vaccinated or not.

 

Thanks,

 

George

 

VascodaGama's picture
VascodaGama
Posts: 3320
Joined: Nov 2010

George,

So far all the 13 available covid-19 vaccines have been administrated indiscriminately of any illness contracted by patients. Initially there was a concern regarding the mRNA vaccines that contain polyethylene glycol (PEG) which can cause anaphylaxis (acute allergic reaction) but so far only few number of side effects, mostly mild, have been reported. The vaccines influence a reaction by the immune system and this is more accentuated at low testosterone. In other words, ADT could lead to a faster adaptation of the immune system to combat the coronavirus. I think that you should get the consensus from your team of physicians treating you to validate your vaccination.

We are now at about the fourth month since the start of vaccination around the world and the outcomes regarding effectiveness are dull. None of the vaccines have proven its effective marks in action as announced by the pharmas after their clinical trials. The 95% is now at 75% on average. The most striking evidence on benefits is lesser symptom experienced by those vaccinated guys that contracted the virus later. In my lay opinion it means that inflammation caused by the virus infection becomes more amenable, probably similar to influenza symptoms.

Surely we need more time to get to conclusions. What is annoying is that vaccination have been arrested by governments around the world and turned into a sort of political affair. The so called green passport required to EU travelers is completely out of the contest in avoiding spread. Vaccination doesn't cure or suppresses contagion. PCR testing, distancing, masks and public hygiene are still the best in controling Covid-19 spread. Confinement continues even to those vaccinated.

Best,

VGama

GeorgeG
Posts: 152
Joined: May 2017

Yes, the best outcomes have been in Asian countries with good mask compliance, widespread tesing and good isolation discipline resulting in death per capita almost 100 times lower than the US, assuming accurate reporting. Here in the states all of this has taken on the political flavor that you reference which has been unfortunate. I am apolitical, just technical by training and a scientist at heart.

I am talking to my medical team about the vaccine but I like getting other opinions as well. Do you think that the mrna vaccines make sense for guys like us in general and what is your opinion about how variants change all of this?

 

George

VascodaGama's picture
VascodaGama
Posts: 3320
Joined: Nov 2010

George,

Variants to sars-cov2 have been present from the very start and surely will oblige to alter the way vaccines are programmed to work. The variant found in Europe one year ago was already different from the one found previously in China in 2019. In fact, up to today several other variants were found but only those seen as potentially aggressive in terms of infectious have been sorted out and studied in detail. For instance; the UK variant (B.1.1.7), the South Africa variant (B.1.351), the Australia variant (B.1.1.317), the Brazil variant (P.1), etc.

Apart from these variants, vaccines will have to be altered to adapt in covering the several mutations of variants. These mutations are now the main concern of the pharmas because they can reduce the effect of existing vaccines but will not render them totally useless. The virus is in circulation passing from person to person (or animals) and many mutate at each doubling occurrence. In other words, we should expect that several mutations coexist at a certain place, to which the vaccine is more or less effective. Just like the common annual flu vaccine where the shot is modified to fit that year's variant/mutation type, the Covid-19 vaccine will require to be altered to the most prevalent type of that particular year.

The pharmas of present vaccines are already working towards that goal. They have synthesized the new DNA or mRNA and introduced it into their new vaccines which will be used as busters for those that took solo the first half of the present shot or at the timing of the typical annual flu shot. Clinical trials are underway.

Please note that I am not a doctor. You should do your own researches and discuss the matter with your doctor.

Best wishes and luck in your PCa journey.

VGama

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VascodaGama
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Joined: Nov 2010

It seems to me that the fast track of approval of the covid vaccines is now the cause of the controversies with the use of AZD1222 in Europe. The health administrators of several countries just decided to object the recommendations of the EU's health monitoring authority (EMA) terminating the use of the vaccine or establishing age groups  for its application based not on the 2020's agencies approvals but on the real outcomes in vaccinated population. In other words, death caused by vaccines become acceptable if many more managed to survive it.

The newer type of vaccines that manages to counter the newer variants are still under clinical trials but again have been announced by the UK government as the option to replace the present Astra-Zeneca vaccine in shooting the youngers (<30), that have faired worse with the approved one. They refer to the AZD7442 taken by our hero Grinder above. 

Here in Portugal, they have no alternatives and started vaccination of students with the AZD1222, that will start attending the schools. It is messy when politics get involved. 

Meanwhile, my wife and I were vaccinated with the Pfizer mRNA two days ago. So far so good.  No symptoms or noticeable side effects. I wonder what will be used  in our second shot. 

Best 

VG

hopeful and opt...
Posts: 2306
Joined: Apr 2009

I glad that you got the shot.

Did you jump up and down when you heard that you were getting it. To be honest, I did!

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