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SIRT Y90 for Liver Tumors - Any opinions/experience?

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Hi,

Came back from the hospital with a 2nd opinion from another oncologist.  Mom has stage 4 colon cancer met liver.  Been on a few chemo combinations for 2 years.  Now this new oncologist says that mom is a good candidate for SIRT Y90 for her liver tumors.  Anyone got experience with SIRT Y90?  Any bad side effects?  I did some research and it seems it has high success rate.

phuckcancer
Posts: 61
Joined: Apr 2016

oh I would like to know as well... we were just told he is a candidate

Grampa2017's picture
Grampa2017
Posts: 6
Joined: Oct 2017

I don't have any experience with this either. Sorry...I have just started research into this, in hope it will help my wife. She was diognosed with mCRC with inoperable met of the liver. We have an consultation at MD Anderson on the 1st to assess the effectiveness of her current treatment plan of folfox + aveston. I'll bring it up then.

Mitch

Trubrit's picture
Trubrit
Posts: 4891
Joined: Jan 2013

I am sorry about your wife's diagnosis. 

I wish you both luck as you move forward.  And I love your avatar/picture. 

Tru

Trubrit's picture
Trubrit
Posts: 4891
Joined: Jan 2013

I know there are folks on the forum who have had the Y90 procedure. Hopefully they'll be along soon to share. 

When my insurance decided not to cover my liver ablation, my surgeon suggested Y90. I ended up with the ablation though - after the surgeon himself took on the insurance company - 

Good luck. 

Tru

Grampa2017's picture
Grampa2017
Posts: 6
Joined: Oct 2017

Thank you Tru,

Our journey has just begun. My wife will have her fourth treatment this morning. Fortunately, she still feels well and remains upbeat.

I've been lurking around trying to soak up as much info as possible. My thanks to everyone for sharing so much of their experiences.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

My mom is scheduled for the Y90 procedure for next month.  It's a 3 part procedure that spread out over a 2 month period.  First they take a body scan map of your blood vessels.  Then a week afterwards will start on the Y90 on one liver.  Stay overnight for observations and hydrations.  Then next month they will do the other liver with overnight stay as well.  They say the procedure is pretty safe and success rates are high.  It won't cure the liver but definitely will shrink the tumors in there so that your liver won't work so hard and therefore will prolong your life.  Will keep you guys updated on the whole progress once we get started.

Joan M's picture
Joan M
Posts: 383
Joined: Oct 2016

I had the procedure in April 2017.  It went really well and my CEA level have been really low since. I remember feeling sick to my stomach for qute a while afterwards. Flu like symptoms are a side effect.   Mine was outpatient for the mapping of arteries and the infusion of the radioactive beads.  

Hope everything goes well for you Mom.

Joan 

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Thanks for the info!
How long was the actual procedure?  Did it require an overnight stay for observations?

phuckcancer
Posts: 61
Joined: Apr 2016

my hubby goes in friday for mapping and 1st treatment next week... 2 weeks later 3rd portion of treatment . i will update on our experience throughout

would love for others who have had it to respond :)

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Good luck to your hubby!!  Let me know how it goes.  My mom's mapping is on Monday.  So let me know so I can prepare her mentally for it!  Thanks!!

Makord
Posts: 36
Joined: Oct 2017

Good luck with this! Where can I read more about this procedure? Haven't heard of it. Does anyone know if it's appropriate for rectal cancer stage 4 with mets in both liver and lungs? 

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

SIRT Y90 is for liver only I think.  First they map the veins in your body.  Then they inject thousands of tiny radiactive spheres in your bloodstream where it feeds to the liver tumors.  Those tiny spheres give direct radiation to the liver tumors.  Radioaction usually lasts 1-2 weeks.  And yes, those tiny spheres will stay in your body but should be perfectly safe.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

In the waiting room waiting for mom to finish her vein mapping.  So here's to update on people that would like to know what they do on the procedure for the mapping.

They take standard vitals, give fluid iv drip.  An anesthesiologist will put you under for the whole procedure.  They will put in a line in the vein on the right groin area.  They will guide the line towards the liver area where they inject contrast so that the machine can see the veins and maps it.  Procedure will take about 1 hour and they want you to stay an additional 4 hours so they can monitor you and make sure you clot properly.  Also make sure you have someone to drive you home as well.

Bellen
Posts: 281
Joined: Aug 2016

Would anyone know - Can this procedure be used for multiple liver mets and/or lesions that are dispersed? CT scans have noted that my larger tumours have shown to be smaller, and that there are not as many smaller ones showing up in the CT scan, although my Onco is saying that they may still be there, just not able to see - still dispersed.  For those who are having this procedure done, or have had it done, I would appreciate if you would report on the procedure - as it may be something I could have in the future.  Thanks so much.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Yes, multiple liver mets ok.  My mom going to get the Y90 on 3 liver tumors.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Got done with the vein mapping.  Mom is mostly resting and laying down to keep the weight off the leg where they entered through the groin area.  Have to keep weight off it for a few days so that it will heal up properly.  We have GREAT NEWS!!  We're doing the Y90 procedure to target 3 tumors in the liver.  CT scans show 2 on the right liver and one on the left liver.  The GREAT NEWS is that the one on the left liver is actually located in the middle of the body closer to the right liver.  And that specific tumor (left liver) is actually being fed by the veins from the right liver.  Therefore mom only needed ONE Y90 procedure to take care of those 3 tumors!!  

In other news, our anesthesiologist is a Norse God...His first name is Thor!! Dr. Thor Milland. Now I'm imagining that the Y90 micro spheres are made by Stark Industries. Laughing

Bellen
Posts: 281
Joined: Aug 2016

Hello debugy - Does your Mom have more liver tumors than the 3 that they did the procedure on?  Just wondering if they would do this procedure on the larger tumors even if there are smaller, dispersed ones.  Yes, very good news about needing only one procedure.  Wishing your Mom well in her recovery.  All the best.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Her main cancer is colon cancer and mets liver.  From what the oncologist says, she has multiple liver tumors but these 3 are the largest ones.  They're going to let regular chemo take care of the smaller ones.  Her actual Y90 radiation procedure will happen next week.  Will let you guys know how it goes and what side effects it might present with.

Bellen
Posts: 281
Joined: Aug 2016

Hello debugy - I have CRC with multiple liver mets.  Have had a little over a yr of folfiri chemo and the larger tumours have shrunk each time I have CT scan.  At first I was told I had about 15 dispersed tumours.  Asked the other day, and was told they saw about 8-9, although some may still be there, but are just not showing up in the scan.  My Onco skyped with other Oncologists and liver surgeons, and they all agreed that I should continue with current chemo cocktail.  He did not say that any liver procedure was recommended at this point.  The one thing he did suggest, because I have been having red and white blood cell issues, and lots of other side effects, is to have a much longer break (about 2 1/2 mos to give my system a chance to get strong again).  Please keep us updated on your Mom's recovery and wishing her all the best.  It sounds like we may have a similar diagnosis.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Definitely seems like same situation.  We've been on chemo for 2 years.  Been off chemo for 2 months since we switched oncologist.  And this new oncologist is way more knowledgeable than our original one.  That's why she suggested the Y90 procedure since it would be good for mom.  She was surprised that the original oncologist didn't recommend it for over half a year since she was a good candidate for it.  So the most important is that you get a 2nd or 3rd opinion on your situation.  Some other oncologist might have better ideas or just more skilled.  Even this new oncologist told us to go check out clinical trials which she helped us setup.  

Hope everything is well with you and wishing you all the best.

Bellen
Posts: 281
Joined: Aug 2016

Also, what chemo cocktail did your Mom have?  I have been having folfiri + avastin prior.  Really causing a lot of side effects that last longer and longer.  Do need this chemo break.  Again, all the best and thank youror keeping us aware of her progress.  

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Nov 2015 - March 2016 - 5-Fu, Oxaliplatin, Leucovorin
April 2016 - May 2016 - 5-Fu, Leucovorin
May 2016 - Oct 2017 - Avastin, Irinotecan
48 cycles so far

The only one that caused neuropathy was oxaliplatin.  Other than that it's the normal loss of hair, nausea, fatigue that comes along with all the chemo.

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Mom's Y90 radiation treatment is tomorrow!!  Wish her luck!! Will keep you guys informed on how it went and such.

phuckcancer
Posts: 61
Joined: Apr 2016

He had the mapping 2 1/ weeks ago and that went well. just a little sore from the groin incision. The dr ordered an MRI for the following Monday to measure the tumor sizing for doage that week. Went back in last week for the 1st treatment (one side of liver) and that went well. No issues other than pain the dy of and some the am after...ohh and a little tiredness. We are scheduled togo back in the week after turkey day for the other side of the liver treatment. The doc will then wait about 6-8 weeks for a scan to review the areas treated.
We have had a wonderful experience with the dr's and staff doing the procedure (which is actually new to the hospital we are at)

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

It seems like we're only doing the right side of the liver since one of the tumors on the left side is actually being fed by the veins from the right.  So can do everything in one go.
Just a question, did they go through the same hole in the groin from the mapping?  Or did they enter at a different place?  And how long was the procedure?

phuckcancer
Posts: 61
Joined: Apr 2016

they did go through the same area...  for you guys?

our day for mapping was a 6:30 check in, taken to procedure room at 8, he was in there about 2 + hrs, then recovery in nucleur med, then in reg room till about 1pm.

treatment about the same... well until about noon.. so it was a little shorter time frame

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Any issues with bowel movement after the procedure?  Mom did the procedure on Thursday afternoon.  Now it's Sunday and she still haven't pooped yet.  Only urine.  Was it similar situation as you?

debugy2k's picture
debugy2k
Posts: 84
Joined: Oct 2017

Y90 procedure was successful.  It took 2 hours for the procedure to complete.  They entered through a vein in the groin area again.  All Y90 spheres were pumped in to the correct locations.  No serious side effects yet other than being told not to move/walk around until the groin area is healed up for awhile.  Not sure if there would be any side effects from the radiation yet.

Annabelle41415's picture
Annabelle41415
Posts: 6244
Joined: Feb 2009

So glad that it was successful.  That has to give you comfort that all went well.  I'd take that as a very good sign that things are looking great going forward.  Thanks for letting us know.  Wishing you the best and a speedy recovery.

Kim

phuckcancer
Posts: 61
Joined: Apr 2016

hard to answer that one as he has GI issues all the time. actually it has been a little better being off the chemo for the radiation.

so glad it went well!!! :)

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