- Search CSN:
- Members: Login to search all areas
- Not a member? Click here to search public areas
You are here
KRAS Mutants.....
|
|
Feb 12, 2013 - 3:30 pm
while i have no idea what ".....a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation" is and neither will you by reading this "abstract "-unless you already know what it is) but you might learn a little about Kras mutation in this brief synopsis http://clincancerres.aacrjournals.org/content/early/2013/02/12/1078-0432.CCR-12-2307.abstract
|
Joined: Jun 2012
That's me (KRAS mutant), but
That's me (KRAS mutant), but at least I'm BRAF wild-type and only Grade 2. Those last 2 make my prognosis a little beter than BRAF mutant and/or Grade 3.
Joined: Nov 2010
thanks steve
always interesting
we should have kept a count of how many papers we have read, must be over 1000
hugs,
pete
Joined: Jan 2013
I am another KRAS mutant, a
I am another KRAS mutant, a pity as targeting EGFR will most likely not work and that excludes a whole class of antibody treatments after avastin fails.
I can however trump you with a PIK3CA mutation as well as KRAS. :)
Joined: Jan 2013
The Study say: "Further
The Study say: "Further analyses revealed enrichment for numerous disease-relevant biological pathways, including glucose metabolism. Functional assessment in vitro and in vivo validated this finding and highlighted the dependence of Kras mutant CRC on oncogenic signaling and on aerobic glycolysis."
Seems like giving up all sugars and most carbs was a good call, despite the insistence of my oncologist that I was making a mistake. :)
Joined: Oct 2009
Don't know if this will be of use:
http://mct.aacrjournals.org/content/12/2/151
or this:
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025132
(might want to look at "Discussion" part on this one unless you're science-literate,which i'm not; i know this one's on "wild" but maybe there's info here that might be of use anyway)
Also,maybe something of substance will result fromthis just announced collaboration between Vanderbilt and Gen Elec
http://eon.businesswire.com/news/eon/20130212006193/en/GE/Vanderbilt/cancer
Joined: Apr 2012
summary of KRAS and BRAF mutation...
The following article helped me better understand KRAS and BRAF tests and the implications to treatment for CRCm.
http://emedicine.medscape.com/article/1690010-overview
Joined: Oct 2009
KRAS,BRAF,PIK3CA gene Mutations:
some potential has been found with something called "gabexate mesilate", tho may not be in US