KRAS Mutants.....

coloCan
coloCan Member Posts: 1,944 Member
in Colorectal Cancer #1

while i have no idea what ".....a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation" is and neither will you by reading this "abstract "-unless you already know what it is) but you might learn a little about Kras mutation in this brief synopsis

http://clincancerres.aacrjournals.org/content/early/2013/02/12/1078-0432.CCR-12-2307.abstract

 

Comments

  • tachilders
    tachilders Member Posts: 313
    #2
    That's me (KRAS mutant), but

    That's me (KRAS mutant), but at least I'm BRAF wild-type and only Grade 2.  Those last 2 make my prognosis a little beter than BRAF mutant and/or Grade 3.

  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #3
    thanks steve

    always interesting

    we should have kept a count of how many papers we have read, must be over 1000

    hugs,

    pete

  • renw
    renw Member Posts: 282 Member
    #4
    I am another KRAS mutant, a

    I am another KRAS mutant, a pity as targeting EGFR will most likely not work and that excludes a whole class of antibody treatments after avastin fails.

    I can however trump you with a PIK3CA mutation as well as KRAS. :)

  • renw
    renw Member Posts: 282 Member
    #5
    The Study say: "Further
    The Study say: "Further analyses revealed enrichment for numerous disease-relevant biological pathways, including glucose metabolism. Functional assessment in vitro and in vivo validated this finding and highlighted the dependence of Kras mutant CRC on oncogenic signaling and on aerobic glycolysis."

    Seems like giving up all sugars and most carbs was a good call, despite the insistence of my oncologist that I was making a mistake. :)
  • coloCan
    coloCan Member Posts: 1,944 Member
    #6
    renw said:

    The Study say: "Further
    The Study say: "Further analyses revealed enrichment for numerous disease-relevant biological pathways, including glucose metabolism. Functional assessment in vitro and in vivo validated this finding and highlighted the dependence of Kras mutant CRC on oncogenic signaling and on aerobic glycolysis."

    Seems like giving up all sugars and most carbs was a good call, despite the insistence of my oncologist that I was making a mistake. :)

    Don't know if this will be of use:

    http://mct.aacrjournals.org/content/12/2/151

     

    or this:

    www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025132

     

    (might want to look at "Discussion" part on this one unless you're science-literate,which i'm not; i know this one's on "wild" but maybe there's info here that might be of use anyway)

    Also,maybe something of substance will result fromthis just announced collaboration between Vanderbilt and Gen Elec

    http://eon.businesswire.com/news/eon/20130212006193/en/GE/Vanderbilt/cancer

     

     

     

  • Phil64
    Phil64 Member Posts: 838 Member
    #7
    summary of KRAS and BRAF mutation...

    The following article helped me better understand KRAS and BRAF tests and the implications to treatment for CRCm.

    http://emedicine.medscape.com/article/1690010-overview

  • coloCan
    coloCan Member Posts: 1,944 Member
    #8
    Phil64 said:

    summary of KRAS and BRAF mutation...

    The following article helped me better understand KRAS and BRAF tests and the implications to treatment for CRCm.

    http://emedicine.medscape.com/article/1690010-overview

    KRAS,BRAF,PIK3CA gene Mutations:

    some potential has been found with something called "gabexate mesilate", tho may not be in US

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