FYI:Oxaliplatin and Irinotecan (tho not together):

coloCan
coloCan Member Posts: 1,944 Member
edited March 2014 in Colorectal Cancer #1
Researchers have recently reported that the severe diarrhea that often results from Irinotecan and may result in a lowering of its dosage or stopping its use, might be mitigated by 4 out of 10,000 compounds they screened (with explanation of how diarrhea is caused here)......rsc.org/chemistryworldNews/2010/November/04111003.asp

tho this will only be of use two or so years from now,next article is perhaps of more immediate usefulness:

Austrailian researchers have found that pyridoxine protects against Oxi- induced neurotoxicity, as per Oncology update, dated 11/5 , more effectively than calcium/magnesium infusions

Comments

  • pepebcn
    pepebcn Member Posts: 6,331 Member
    #2
    This is very interesting!
    thanks for posting it!
  • AnneCan
    AnneCan Member Posts: 3,673 Member
    #3
    Very interesting, Steve!

    Very interesting, Steve!
  • Kathryn_in_MN
    Kathryn_in_MN Member Posts: 1,252 Member
    #4
    Page not available
    The rsc page came up not available for me.

    Unfortunately the following page was not available:
    http://rsc.org/chemistryworldNews/2010/November/04111003.asp

    This might be because:
    •You may have typed the web address incorrectly. Please check the address and spelling ensuring that it does not contain spaces.
    •It is possible that the page you were looking for may have been moved, updated or deleted.
  • coloCan
    coloCan Member Posts: 1,944 Member
    #5
    Kathryn_in_MN said:

    Page not available
    The rsc page came up not available for me.

    Unfortunately the following page was not available:
    http://rsc.org/chemistryworldNews/2010/November/04111003.asp

    This might be because:
    •You may have typed the web address incorrectly. Please check the address and spelling ensuring that it does not contain spaces.
    •It is possible that the page you were looking for may have been moved, updated or deleted.

    try this site instead (rsc- was first I'd seen this on)(sorry)
    newswise.com/articles/view/570393/?sc=dwhn

    title.....Discovery Blocks Cancer Drug's Toxic Side Effect


    rsc=Royal Society of Chemistry
  • Kathryn_in_MN
    Kathryn_in_MN Member Posts: 1,252 Member
    #6
    coloCan said:

    try this site instead (rsc- was first I'd seen this on)(sorry)
    newswise.com/articles/view/570393/?sc=dwhn

    title.....Discovery Blocks Cancer Drug's Toxic Side Effect


    rsc=Royal Society of Chemistry

    Thanks Steve
    I hope they come up with a drug to use for this soon. Unfortunately I've now learned first-hand about the nasty BIG D from Irinotecan...
  • taraHK
    taraHK Member Posts: 1,952 Member
    #7
    thanks and individual perspective
    Thanks for posting this -- very interesting.

    I'm on Irinotecan (CPT-11) now. I had severe diarrhea. Well, maybe moderate. For several cycles, I had severe diarrhea once or twice per cycle requiring immodium "blasts" (6-12 in a 12 hr period). That was OK....Do-able. But after one fairly intense bout my onc decided to reduce my dose by 20% for one cycle. No diarrhea. Then he put me back on the old dosage -- and I haven't had severe diarrhea (requiring anything) since. ???? Weird? Can't be psychosomatic, can it???? I have very slightly changed my diet, perhaps (from TONS of green veggies to LOTSA green veggies....I still eat fruit esp fresh berries every day). Anyway -- just sharing an interesting personal experience.

    Thanks again for the articles/references.

    Tara

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