NavDX positive test

UPDATE: on mets from my Head and Neck HPV SCC P16. After 7 months of the NavDX blood test going up and not showing up on a PET scan. It showed up with a 1.1cm tumor on my left lung. They removed the Tumor on Oct 14th in Virginia Mason hospital in Seattle. I got another NavDX blood test back this week still showing a positive level of 18. This is from a high before surgery of 210. My Tumor pathology report came back with PERTINENT POSITIVE FINDINGS: PD-L1 expression for Keytruda (CPS=60)….. I start my Keytruda next week and every 6 weeks for two years.I will be doing the NavDX every 3 months along with a PET scan. I wish you all a happy Thanksgiving and a wonderful holiday season……..Bill…….P.S. my Ct guided biopsy of the tumor originally showed negative for PD-L1. It just shows you how much more info you get from the tumor…..

Newby here…….Thanks to everyone for sharing their experiences as there is a wealth of info in this thread. Having gone thru most of the thread here I noticed the number/scoring of the NavDx test is considerably lower compared to the results I have received. My oncologist has been ordering the NavDx tests for me since 10/2023 and my numbers have ranged from a low of 257 to a high of 46000. I am currently in METS stage (liver and bone). Originally diagnosed BOT HPV P16+ in 2016, and Prostate cancer 2020. BOT treatment was chemoradiation, and prostate was surgically removed. PSA tests consistently less than 0.01.

That gives me hope OhNoltsMe. I’m going through my second type of chemo treatment (first one carboplatin, 5 flourosil, keytruda was unsuccessful) since METS and my recent NavDx score is 753. Scans show lesions in liver shrank from 3cm down to .6 cm. I’m in year 8 of this marathon.

My husband had quarterly NavDx testing done, and that continued for 2 years. At the 2 year mark his NavDx spiked from 12 to 73 and they found a very small liver met, which was removed via a scope using robotic assisted tech. They continued to test quarterly, until he had 3 negative (zero) tests, then moved his testing to a every six months schedule. I think it just really depends on the results they are seeing during the post treatment phase.

His NavDx came down from 31, 000 midway through treatment to 174 on his last treatment day and then to zero at the 30 day post treatment mark.

If not for NavDx I’d be going in for quarterly scans. Instead I’m choosing to go in for a quarterly NavDX test and annual scans and believe that is a more accurate way to track my situation.

My NavDx score went to zero about 13 months Into my Pembro immunotherapy trial.

Just my situation.

That sounds like a very sound follow up plan. As long as the NavDx remains at zero, I think annual scans will prove to be enough. It sure beats having to deal with the scanxiety!

Update: I had Surgery in Oct for a 1.1cm tumor on my left lung. This was mets from my Head and neck cancer I had in 2021. My NavDX before surgery was 210 and after surgery it was 18. I had a PET in the first part of January that showed a Nodule that didn't show anything in the last 3 PET scans going from 3mm and no uptake to 5mm and SUV 2.3. I now have two doses of Keytruda on board. My Rad team says to wait and see what the Keytruda does and get another PET scan in 3 months. My Oncologist says the something. My Surgeon said he could do a wedge and take it out. I'm going to wait a few months to see what my next NavDX on Feb 10th says and then repeat the PET in April. By the time I do my next PET scan I will have 4 doses of Keytruda under my belt……I hope everyone is doing well…Bill

have they done a genetic sequence test on your tumor, if it some back positive then i cant see why they wouldnt start it immediately, dont be afraid to explore with a new provider. my first provider never even did a genetic sequence test, even after mine cancer had metastasized, my nest provider ran the test after my first visit. i think a lot of the decision is the finacaials of the provider, what can we do and hope it still works and make the most money my first PET after the new facility, the cancer had spread all over my chest, it took 5 treatment one every 3 weeks and my cancer was gone.

Well, hare2today welcome to the CSN H&N cancer forum.

You have certainly had your share of H&N cancer.

And unfortunately you were one of the unlucky ones like me that also got a recurrence.

So your second cancer treatment sounds like it was successful as was your first except your NavDx test now is still elevated above 0.

Prayers for you that the new PET and NavDx test are unremarkable with NED ( No Evidence Of Disease)

Fight on.

Our motto here is NEGU (Never Ever Give Up)

Wishing you the very best…

Take Care, God Bless

Russ

Also, I recommend when you get a chance check out the "SuperThread" at the top of the page on the home page of the Head and Neck Forum here. It is a gathering of information, links, videos, etc. to help those dealing with H&N cancer.

I had a tonsillectomy, Modified radical neck dissection, skin graft, a pectoral flap all on 1/18/2022. I did my second round of radiation 5 weeks after surgery. That radiation ended 3/28/22. A month later is when I did the NAVdx which was 0 and has been since. My dr just ordered one for my 3 yr follow up visit but I fully expect a 0 again.