ADT Side Effects & Different ADT Drugs

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Comments

  • Oldernow
    Oldernow Member Posts: 47 Member
    #22
    https://csn.cancer.org/discussion/comment/1718091#Comment_1718091

    I was told that as long as my PSA stays non-detectable that testosterone replacement would have no effect. It sounds counterintuitive but that's what the docs have told me.

  • Old Salt
    Old Salt Member Posts: 1,505 Member
    #23

    Testosterone Replacement Therapy (TRT) has to be used very carefully, if at all. A full discussion is outside the focus of this thread.

  • Josephg
    Josephg Member Posts: 455 Member
    #24

    My Oncologist told me that I would have to be in remission for 5 full years, before a discussion of Testosterone replacement therapy could take place, as the risk of awakening any injured, but not yet dead cancer cells, associated with this therapy is too high. I've been under the stewardship of this Medical Oncologist specializing in PCa for almost 13 years, and I trust my life to their opinion.

  • alampy
    alampy Member Posts: 1 Member
    #25

    All' the best.I think I wll also follow your path

  • eonore
    eonore Member Posts: 185 Member
    #26
    https://csn.cancer.org/discussion/comment/1718127#Comment_1718127

    My oncologist takes the same position. I reached the five year point last June, and still have found it hard to pull the trigger.

  • mamakath
    mamakath Member Posts: 2 Member
    #27

    Is there a correlation between length of cancer cell suppression with ADT and length of libido suppression?

  • Old Salt
    Old Salt Member Posts: 1,505 Member
    #28
    https://csn.cancer.org/discussion/comment/1718557#Comment_1718557

    Yes, basically the longer one is on ADT, the greater the CHANCE of not getting back to normal (libido etc). Age plays a major role in this as well.

  • Josephg
    Josephg Member Posts: 455 Member
    #29

    Absolutely true in some cases, but every case is different. For me, I had 2 years of ADT (Lupron, Zytiga, Prednisone) on my second round of ADT (first round was 11 years ago with Lupron, Casodex for 6 months), and today, almost 2 years after the second round of ADT treatments stopped, my Testosterone level has only risen to 27, and it is unlikely to rise much further. Hence, a permanent loss of libido. For reference, I am almost 72 in age.

  • SuperDave
    SuperDave Member Posts: 4 Member
    edited November 24 #30

    Has anyone on this or any other cancer.org thread discussed using simple OTC senolytics (eg. fisetin) to limit the ongoing damage caused by radiation and/or chemo?

    “Cancer treatment–induced early aging accounts for significant morbidity, mortality, and health expenditures among cancer survivors. One major mechanism driving this accelerated aging is cellular senescence; cancer treatments induce cellular senescence in tumor cells and in normal, nontumor tissue, thereby helping mediate the onset of several chronic diseases.”

    https://pubmed.ncbi.nlm.nih.gov/35775492/

    Background: When the cell's DNA is sufficiently damaged by radiation or chemotherapy agents, many of the surviving cells enter a "senescent" phase, where they stop dividing and shut down most normal cellular functions. These cells unfortunately hang around and continue to secrete harmful signaling molecules that generate damaging inflammatory responses. Senolytics are compounds that selectively kill these senescent cells by pushing them over the apoptotic edge.

    The benefits in preclinical studies are very impressive, and the safety profiles appear to be fine. I think it really is worth pushing the clinicians you work with into at least reading up on senolytics. My guys were not even aware of this treatment option. After explaining it to them, they were still extremely hesitant to recommend anything not FDA approved, and in the current tort environment I get that.

    That doesn't mean its not a good idea. I've done it. I think it worked.

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