Lymph vascular space invasion (LVSI) on pathology report

I had that on my path report. The cancer had penetrated the uterine wall 89% and I have involvement in the lymphatic space with metastatic cancer foundation in one left pelvic lymph node of 12 removed. My diagnosis is Endometriod Endonetrial adenicarcinoma stage 3C1 Grade 1

Welcome to the board, Lyn. As "No Time" said, there are women here who can share their experience with you. 

Love,

Eldri

Hi Lyn, I had my surgery in May 1999 and my pathology report indicated that my LVSI was extensive.  I've seen references online to a three-tiered system for reporting of LVSI which includes: (1) no LVSI; (2) mild or focal LVSI; and (3) severe LVSI.  Since my LVSI was determined to be extensive, it would fall into the severe category.  Does your pathology report give any more information on the extent of your LVSI? 

My pathology report stated "The tumor shows vascular space invasion into parametrial and lower uterine segment soft tissue." I guess this would make me a Tier 2 according to MoeKay's references (thanks for sharing this MoeKay).

The tumor measured 5.1 cm, invading 0.5 cm out of a total myometrial thickness of 1.3 cm. Staged as 3B, Grade 3, uterine carsinosarcoma (MMMT). 

This was one of the factors considered when I was deciding on external radiation after chemo. I'm still NED 3 years after treatment.

My pathology report showed LVSI when I had my hysterectomy in 2014. My oncologist recommended radiation as a result. 

Jan

Lyn70 said:

LVSI invasion

My oncologist said my LVSI was extensive as it was in both ovaries. Two pathologists reports said I was very high risk for metastasis.The tumor invaded within 1mm of serosa.  I had my first of 6 Taxol/Carboplatin chemo 1/13. I will have 4 weeks of radiation. I am very fearful. 

Lyn, I too was very anxious after surgery when I learned about my risk factors for recurrence.  When I was diagnosed in 1999, chemotherapy was not standard of care for my stage and grade of cancer.  I would have felt much more comfortable if I had chemo since I was worried about distant spread, which the radiation I had did not address.  I found that the fear and anxiety slowly got better with the passage of time, but I initially needed medication to get through the rough spots.  Good luck as you complete your treatment!

Lyn70 said:

I am so relieved to find this

I am so relieved to find this site and others with the same diagnosis of LSVI on their path report. It gives me hope. My pelvic lymph nodes were not removed due to frozen section looking like IA and my surgeon not wanting to cause lymphedema. My Ct showed one 9mm node in external ileac which was commented as possible metastases or possible normal. I had one treatment 1/13 contracted covid and go for monoclonal antibodies tomorrow. I am trying to remain in faith and calm. 

The antibodies are doing their thing and you get Covid behind you ASAP so you can concentrate on treatment.  This sure was a double whammy. Do let us know how you are doing. 

I had both LVSI and a positive pelvic wash.  Was diagnosed endometrioid endometrial adenocarcinoma Stage IVB Grade 2.  Thankful to report I am 3 years and 4 months NED from end of chemo.  No radiation. 

Lyn70 said:

I am glad to report covid is

I am glad to report covid is behind me and the monoclonal antibodies did work. Covid delayed my second treatment but I just had treatment #3 and #4 coming up on 3/24. Fatigue is my major issue but I try to walk atleast 1 mile daily, 2 if I am feeling strong. Neulasta follows each treatments so bone pain comes at night but I take Claritin to help. I learned about the Alpha supplement for neropathy on this site. TY. I am feeling a little better about getting out but my vaccine delayed until 4/26 due to antibody therapy so wearing 2 masks and minimizing exposure. Sometimes I feel blessed and encouraged and other times I throw myself a huge pity party. 

Happy to hear that your Covid episode has ended and that you have restarted treatment. Fatigue and the bone pain are quite common amongst the members here. Others have also found Claritan to help with the bone pain.

But conflicting emotions are normal while you're going through trreatment. And getting some exercise is very good, but accept that your energy level won't be the same while getting chemo. Your body is fighting hard now to process the chemo and you've only just gotten over a very serious illness. Be kind to yourself.