Vaccine 90 percent effective

Grinder said:

Status

Hi guys...

An update. Waiting game now. Btw thanks for the sentiment but you are being way too nice. 

This is not a Lilly study after all but is an AstraZeneca application of the Lilly antibody treatment but as a preventative measure instead of treatment for symptoms.

Physician's Research Group is conducting a pair of clinical trials focused on the prevention of COVID-19. These studies use monoclonal antibody therapy, which serves as a medication alternative to the vaccine for those who seek additional options

I sent my medical history and now its a waiting game to see if my medical profile matches a group profile they are seeking for this research. I do know they are especially seeking over 60s for this study... Whether or not a Prostate Cancer survivor fits their desired profile is yet to be determined. 

If my medical profile matches, I will be brought in for screening, and I will bring the consent forms with me. 

After the screening, if I pass the screening, they will test for covid several times throughout, will get two shots of the antibody treatment in my buttcheek, will have blood draws then and during 7 more visits, plus constant health monitorung and other tests.

When I was an intern at the Psychiatric Research Center as a grad and undergrad, running neurochemical experiments on behavior in rats and pigeons for the researchers, I did not know the tables would turn, and I would someday be the lab rat getting the injections and being observed. 

Turns out, this preventative measure is for demographics that cannot take the messengerRNA vaccine... But the drawback is that it is estimated to last only up to 6 months before needing a booster. So it is not a magic bullet necessarily.

Many thanks for volunteering and putting yourself on the front lines.  I hope you get picked and help make the coronavirus a mere nuisance.

Eric

I'll tell you guys what I told my wife...

Do you really want to inflate my ego any bigger than it already is?

She said HECK NO!

LoL ???

(Just kidding)

Grinder the Hero, 

Yes, you describe all in doubles so you may get effects in double too. Lol

This ADZ7442 has been given to covid patients in phase 2 showing reliability in the cure. In this phase 3 (your timing) they will check its capabilities in prevention and treating. All those tests done before the injection is to group you in the prevention or treatment cohort in case you are negative or positive to the virus. 

I wonder if they give you the blood test results. It would be good if you retain a copy to compare the markers at the six months milestone. 

The good things in clinical trials is the constant attention provided by the professionals. We couldn’t be safer. 

Here are details on the trial:

https://www.precisionvaccinations.com/vaccines/covid-19-antibody-azd7442

The EU population were set to receive the Astra-Zeneca AZD1222 vaccine used in the UK but due to manufacturers restrains some countries started to use other vaccines from different pharmas which I believe that they get to identical outcomes as these work similarly in terms of prevention. EU officials that have politicized the vaccination program are now in war against Astra-Zeneca’s default insisting them to deliver the contracted numbers the soonest. It would be nice if Astra-Zeneca instead delivers the AZD7442.

The AZD1222 is a sort of flu vaccine known as “adenovirus vaccine" which uses a virus studied and in use for many years in similar vaccines. This virus is altered to carry a gene for sars-cov2 protein that, in time, will then educate our immune system to recognize the bandit.

I wonder why was the shot done at the buttocks?

Thanks for the update.

VGama

Not much to comment on this update. The first follow up visit was checking vital signs and looking for side effects. As far as I can tell everything is tip top.

Instead of going back every week, there looks like a 2-3 week lull between visits. So this study stretches the visits out longer than what I thought... as long as there are no health complications of any sort.

Vasco... you are right, they take good care and are very conscientious. And if I contract Covid during the study for any reason, even if the transmission has nothing to do with the study participation, they will provide the best care available at the best facility available with the best professionals available, all paid for by AstraZeneca at no cost to me or my insurance.

After hearing about the study from me, several friends have notified relatives, who cannot take the vaccine for a variety of reasons, that this preventative treatment will hopefully be available next year. I don't know if the wheels of research can move that quickly, but I am hoping they will. I will ask at the next visit when is the earliest they can project, assuming all goes as planned, which it seems to be doing. 

Does anyone have any data or perspective on any of the vaccine types and its compatibility with active PC and/or ADT/Firmagon? I am trying to decide if I am going to get vaccinated or not.

Thanks,

George

Yes, the best outcomes have been in Asian countries with good mask compliance, widespread tesing and good isolation discipline resulting in death per capita almost 100 times lower than the US, assuming accurate reporting. Here in the states all of this has taken on the political flavor that you reference which has been unfortunate. I am apolitical, just technical by training and a scientist at heart.

I am talking to my medical team about the vaccine but I like getting other opinions as well. Do you think that the mrna vaccines make sense for guys like us in general and what is your opinion about how variants change all of this?

George

Georges Calvez said:

Wait and see

Hi there,

I am waiting to see what happens three or four weeks after 60 - 70 % of the population is vaccinated, in theory there should be a drastic decline in the number of cases.
The UK has done a high proportion of the 80+ population and is working on the 70+ part of the population now, now up to 9.8% of the total adult population vaccinated.
As these are the high risk groups the line should start to fall soon.
France is a long way behind, so we are still sitting it out, I am waiting for that cold glass of cider in the Café Le Finistère in the summer, but I might have to have it in the garden at home.

Best wishes,

Georges

I got Dose 1 of the Pfizer vaccine yesterday.  Zero side effects one day later.  I am auto-immune compromised  over ten years now, due to lymphoma and chemo, and also have lymphadenopathy due to a diagnosed immunological disease, so me having no side-effects is somewhat interesting.   My state of SC has only around 5.3 million people, but around 1.5 million have been vaccinated with at least Round 1, which is very roughly 30%.   (One lone hospital in Charleston has administerd 150,000 doses itself.)  Positive Covid test results are at about 3.4% statewide.   Two months ago, we were at over 20%, one of the highest in the nation.   

Total deaths in this state, as of two days ago, is almost exactly 9,000.  Out of 5,300,000.   Statistically, zero % were patients under 50; perhaps 25 individuals.  The sky is not falling.  Bless France, the land of the best wines,

max

It seems to me that the fast track of approval of the covid vaccines is now the cause of the controversies with the use of AZD1222 in Europe. The health administrators of several countries just decided to object the recommendations of the EU's health monitoring authority (EMA) terminating the use of the vaccine or establishing age groups  for its application based not on the 2020's agencies approvals but on the real outcomes in vaccinated population. In other words, death caused by vaccines become acceptable if many more managed to survive it.

The newer type of vaccines that manages to counter the newer variants are still under clinical trials but again have been announced by the UK government as the option to replace the present Astra-Zeneca vaccine in shooting the youngers (<30), that have faired worse with the approved one. They refer to the AZD7442 taken by our hero Grinder above. 

Here in Portugal, they have no alternatives and started vaccination of students with the AZD1222, that will start attending the schools. It is messy when politics get involved. 

Meanwhile, my wife and I were vaccinated with the Pfizer mRNA two days ago. So far so good.  No symptoms or noticeable side effects. I wonder what will be used  in our second shot. 

Best 

VG

I wonder about Grider's experience with the clinical trial on mab style vaccine AZD7442. Pharmers doing the trial have reported on this phase-3 failure informing that the vaccine did not avoid symptomatic covid infections. I hope Grinder is OK as it has passed already five months since his post informing on his participation.
https://www.clinicaltrialsarena.com/news/astrazeneca-covid-drug-trial-data/

Meanwhile the latest news from Israel regarding Pfizer 's effectiveness are not the best as it declined from 93% to 64% in preventing both infection and symptomatic disease. The number of newer covid cases in double-vaccinated people is rising, particularly accentuated since the spread of the Delta variant and the end of social distancing restrictions.
Though the efficacy of all vaccines were similar under controlled circumstance such as in clinical trials, their effectiveness (working well in the real world) are showing differences.
Pfizer vaccine (and probably Moderna) seams to be more effective than other vaccines on the market in preventing hospitalizations and serious illness from the coronavirus at an envy 97%. I believe that this was what health authorities around the world were expecting as it reduces the number of severe illnesses and deaths.

Having a double-vaccine certificate allows folks to travel in the EU countries but, as the data shows, this do not guarantee that the traveler is immune to the virus or that he doesn't carry it in his baggage. Portugal permits the entrance to vaccinated visitors from almost all countries (Brazilians have to do quarantine) but those arriving in Germany from Portugal are subjected to quarantine, independently of having a negative PCR test or being vaccinated.

It is still premature to decide on what to do. Let's keep safe maintaining distancing, using masks and washing our hands.
Best to all
VG