Promising Lynch Article

It's a phase 1 trial for only 6 months, that measured certain inflammation markers, not actual cancer outcomes. I'd say it might serve to make you feel better about a choice you had already made for other reasons, but isn't any kind of evidence to take the drug for that purpose. These kind of findings routinely disappear on further study or the balance of pros and cons are found to be worse. They're interesting for sure.

I have a type of inflammatory bowel disease called microscopic colitis, and NSAIDs are one of the triggers, which made this study interesting to me. I think aspirin is thought to reduce colon cancer risk, and yet other types of IBD (and other chronic inflammatory states) can cause increased risk of cancer. Our bodies are so complicated. 

I'm another MSH6 – Lynch member. I have an endoscopy/colonoscopy every two years too. Frankly, none of the concoctions I've been given to take before the procedure have ever worked as well or as quickly as the one I used for my first colonoscopy many years ago. But that product was banned since some people developed kidney problems after using it. Since then I've used both prescription and/or non-prescription methods, depending upon the doctor doing the procedure.

However, I've found it helpful to reduce the bulk in my colon a few days before starting the prep by following a low fiber diet. Here's a link that explains the process:

https://healthy.kaiserpermanente.org/washington/get-care/additional-services/gastroenterology/colon-diet-low-fiber

Otherwise, like Cindi, I drink broth (I prefer the beef flavor) and eat jello the day before.

I've become used to this whole process since I also get severe diarrhea from the contrast solution that I take before a CT-scan. So I do a modified colon prep before each of those as well.