What’s Coming Down the Pike

sblairc · February 2014

GSRon said:
First this post needs to be
First this post needs to be back at / near the top.. too important. Also please be aware of AACR.. I will post a link later..

Ron

Thank you!!!

Wow, this information is amazing. I am literally in tears. My hope for the future of my husband and everyone here is in these promising therapies. Thanks for bumping this post up, especially for us new to the forum. Hope. . .

GSRon · February 2014

sblairc said:
Thank you!!!
Wow, this information is amazing. I am literally in tears. My hope for the future of my husband and everyone here is in these promising therapies. Thanks for bumping this post up, especially for us new to the forum. Hope. . .

No thanks needed.. it is the

No thanks needed.. it is the "job" of olde farts like me to help all I can. Keep in mind some of the info is already a bit dated.. but some of us will continue to add the new stuff we hear of...

Here is the AACR link.. http://www.aacr.org/

Be Well All..!!

Ron

GSRon · February 2014

GSRon said:
No thanks needed.. it is the
No thanks needed.. it is the "job" of olde farts like me to help all I can. Keep in mind some of the info is already a bit dated.. but some of us will continue to add the new stuff we hear of...

Here is the AACR link.. http://www.aacr.org/

Be Well All..!!

Ron

AACR info

OK, here is a bit more info on the 2014 AACR Conference. This is a huge annual conference with a big group of the best Cancer researchers.. I will be attending as a Patient - Advocate, which means I have to give a presentation. But I will also try to attend all related sessions and make notes to share. Here is a link to the conference info.. http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

Ron

GSRon · February 2014

GSRon said:
AACR info
OK, here is a bit more info on the 2014 AACR Conference. This is a huge annual conference with a big group of the best Cancer researchers.. I will be attending as a Patient - Advocate, which means I have to give a presentation. But I will also try to attend all related sessions and make notes to share. Here is a link to the conference info.. http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

Ron

A good read on.. Immune

A good read on.. Immune Checkpoint Inhibitors

http://www.washingtonpost.com/national/health-science/new-therapies-raise-hope-for-a-breakthrough-in-tackling-cancer/2014/02/14/b4f8e4fc-8dad-11e3-95dd-36ff657a4dae_story.html

PD-1 PDL-1...

Soon we hope..!

Ron

BDS · February 2014

Are fruit flies the key in the fight against cancer?

Ok this has nothing to do with RCC but it's really cool - watch this - BDS

http://www.cbsnews.com/videos/are-fruit-flies-the-key-in-the-fight-against-cancer/

NanoSecond · February 2014

BDS said:
Are fruit flies the key in the fight against cancer?
Ok this has nothing to do with RCC but it's really cool - watch this - BDS

http://www.cbsnews.com/videos/are-fruit-flies-the-key-in-the-fight-against-cancer/

Interesting

Actually, it did have one oblique connection to the treatment of RCC. One of the drugs that they determined would be effective against his thyroid cancer was Nexavar (Sorafenib)...

BDS · March 2014

Nivolumab

Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN. Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27^th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS

*** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way. I would really appreciate a little bit of discretion. – Thank you

sblairc · March 2014

BDS said:
Nivolumab

Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN. Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27^th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS

*** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way. I would really appreciate a little bit of discretion. – Thank you

Getting the drug outside of clinical trials?

Are there any exceptions for getting the drug outside of clinial trials? I was just wondering if you can get experimental medication for compassionate reasons.

i_love_my_dad · March 2014

BDS said:
Nivolumab

Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN. Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27^th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS

*** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way. I would really appreciate a little bit of discretion. – Thank you

I think it can hardly be

I think it can hardly be approved for kidney cancer soon. But can it be approved for Melanoma earlier? I think people can reach it as long as it is FDA approved, no matter for which kind of cancer.

Darron · March 2014

sblairc said:
Getting the drug outside of clinical trials?
Are there any exceptions for getting the drug outside of clinial trials? I was just wondering if you can get experimental medication for compassionate reasons.

Not easy

I, like many, am still taking Nivolumab after being declared cancer freeze in my Jan 2 scan. The original trial was rinstop treatment at NED. That was amended to try and establish a maintenance dosing protocol. I think it is moving quicker than originally thought, but still not quick enough!

I had asked if it is possible to get back in the drug if I went NED, was dropped, then had a recurrence. I was told that I could not go back in the trial, but I could apply to the FDA for an individual liscence vs. Under the trial licence, but it would be difficult. Also, the coat would most likely not be covered on insurance, or trial. It sounded like a dead end.

That is why you will read about dictors working the trial and keeping their patients on the drug as long as possible

yoricks · April 2014

A year after the original

A year after the original post, if I were to summarize where we are now:

1. No new treatments were approved or a positive Phase III trial completed.

2. Tivozanib and Dovitinib, which were in final stages, failed.

3. We still have 4 new treatments in Phase III clinical trials:

A. Cabozantinib – Exelixis.

B. Nivolumab -BMS

C. IMA901 - Immatics

D. AGS 003 – Argos

We have of course dozens of phase I and II trials which need a separate cover.

Did I get it right?

yoricks · April 2014

Novel treatments in Phase

Novel treatments in Phase II:

1. RO 4929097

Roche

2. BEZ 235

Novartis

3. MK 2206

Merck

4. Pidilizumab/ CT 011

CureTech

5. Anlotinib

Jiangsu Chia-tai Tianqing Pharmaceutica

6. Carfilzomib

Onyx Therapeutics, Inc.

7. Bortezomib/ Velcade

Millennium Pharmaceuticals

8. ASONEP

Lpath, Inc.

9. TH 302

Threshold Pharmaceuticals

10. TRC 105

TRACON Pharmaceuticals

11. Trebananib/ AMG 386

Amgen

12. Famitinib

China

13. Lipotecan/TLC388

Taiwan Liposome Company

14. Dalantercept

Acceleron Pharma, Inc.

15. AZD 2014

AstraZeneca

16. LY2510924

Eli Lilly

17. MPDL3280A

La Roche

18. GDC 0980

La Roche/Genentech

19. Tasquinimod/ ABR-215050, CID 54682876

Ipsen

20. INC280

Novartis/Incyte

21. MK 3475

Merck

22. RX 0201

Rexahn

GSRon · May 2014

yoricks said:
Novel treatments in Phase
Novel treatments in Phase II:

1.      RO 4929097

Roche

2.      BEZ 235

Novartis

3.      MK 2206

Merck

4.      Pidilizumab/ CT 011

CureTech

5.      Anlotinib

Jiangsu Chia-tai Tianqing Pharmaceutica

6.      Carfilzomib

Onyx Therapeutics, Inc.

7.      Bortezomib/ Velcade

Millennium Pharmaceuticals

8.      ASONEP

Lpath, Inc.

9.      TH 302

Threshold Pharmaceuticals

10. TRC 105

TRACON Pharmaceuticals

11. Trebananib/ AMG 386

Amgen

12. Famitinib

China

13. Lipotecan/TLC388

Taiwan Liposome Company

14. Dalantercept

Acceleron Pharma, Inc.

15. AZD 2014

AstraZeneca

16. LY2510924

Eli Lilly

17. MPDL3280A

La Roche

18. GDC 0980

La Roche/Genentech

19. Tasquinimod/ ABR-215050, CID 54682876

Ipsen

20. INC280

Novartis/Incyte

21. MK 3475

Merck

22. RX 0201

Rexahn

Immunotherapy... Check out

Immunotherapy... Check out this video.. it is an hour long.. pull up a chair..

https://www.youtube.com/watch?v=XGeqAEr1RnE&list=UUIRzxohZ6SbwsPqHFQGMJ7A

Ron

GSRon · June 2014

GSRon said:
Immunotherapy... Check out
Immunotherapy... Check out this video.. it is an hour long.. pull up a chair..

https://www.youtube.com/watch?v=XGeqAEr1RnE&list=UUIRzxohZ6SbwsPqHFQGMJ7A

Ron

Bump..!

Bump..!

Galrim · June 2014

GSRon said:
Bump..!
Bump..!

We need stickies in these forums

But I have mailed the moderators about this to no avail...

/G

GSRon · June 2014

Galrim said:
We need stickies in these forums
But I have mailed the moderators about this to no avail...

/G

I agree.. a sticky on this

I agree.. a sticky on this one would be a good thing... in the mean time.. have to "bump" it every now and then...

Ron

CSN_Rowan · June 2014

Galrim said:
We need stickies in these forums
But I have mailed the moderators about this to no avail...

/G

Hi Galrim,
I'm actually

Hi Galrim,

I'm actually looking in to creating a sticky for this right now, and if there is a reason that we can't easily put a sticky on this board we'll let you know. Thank you for your continuing support of new members!

Rowan

CSN Support Team

GSRon · June 2014

CSN_Rowan said:
Hi Galrim,
I'm actually
Hi Galrim,

I'm actually looking in to creating a sticky for this right now, and if there is a reason that we can't easily put a sticky on this board we'll let you know. Thank you for your continuing support of new members!

Rowan

CSN Support Team

Awesome..!
Thanks..!
Ron

Awesome..!

Thanks..!

Ron

GSRon · July 2014

GSRon said:
Awesome..!
Thanks..!
Ron
Awesome..!

Thanks..!

Ron

Here are two links.. one is

Here are two links.. one is an early report on a new combo drug trial.. But a 79% plus response rate is amazing..!!

http://ecancer.org/news/5738-asco-2014--ipilimumab-with-nivolumab-achieves-long-term-survival-in-advanced-melanoma.php

And some interesting RCC news..

http://ireport.cnn.com/docs/DOC-1147923

Ron

GSRon · July 2014

GSRon said:
Here are two links.. one is
Here are two links.. one is an early report on a new combo drug trial.. But a 79% plus response rate is amazing..!!

http://ecancer.org/news/5738-asco-2014--ipilimumab-with-nivolumab-achieves-long-term-survival-in-advanced-melanoma.php

And some interesting RCC news..

http://ireport.cnn.com/docs/DOC-1147923

Ron

Here is another link from the

Here is another link from the recent ASCO Conference. This video tells a broader tale on the Ipi combo with Nivo. You Southern California people, may want to check out when this combo may show up at City of Hope.. Looks like there may be some difficult side effects, but the rewards should be well worth it.. You know I will be watching this combo..

http://cancergrace.org/kidney-cancer/2014/07/02/asco_2014_hottest_thing_late_stage_kidney/

Ron

What’s Coming Down the Pike

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17. MPDL3280A

17. MPDL3280A

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