What’s Coming Down the Pike

124

Comments

  • sblairc
    sblairc Member Posts: 585 Member
    GSRon said:

    First this post needs to be

    First this post needs to be back at / near the top.. too important.  Also please be aware of AACR.. I will post a link later..

    Ron

    Thank you!!!

    Wow, this information is amazing. I am literally in tears. My hope for the future of my husband and everyone here is in these promising therapies. Thanks for bumping this post up, especially for us new to the forum. Hope. . . 

  • GSRon
    GSRon Member Posts: 1,303 Member
    sblairc said:

    Thank you!!!

    Wow, this information is amazing. I am literally in tears. My hope for the future of my husband and everyone here is in these promising therapies. Thanks for bumping this post up, especially for us new to the forum. Hope. . . 

    No thanks needed.. it is the

    No thanks needed.. it is the "job" of olde farts like me to help all I can.   Keep in mind some of the info is already a bit dated.. but some of us will continue to add the new stuff we hear of...

    Here is the AACR link..  http://www.aacr.org/

    Be Well All..!!

    Ron

  • GSRon
    GSRon Member Posts: 1,303 Member
    GSRon said:

    No thanks needed.. it is the

    No thanks needed.. it is the "job" of olde farts like me to help all I can.   Keep in mind some of the info is already a bit dated.. but some of us will continue to add the new stuff we hear of...

    Here is the AACR link..  http://www.aacr.org/

    Be Well All..!!

    Ron

    AACR info

    OK, here is a bit more info on the 2014 AACR Conference.  This is a huge annual conference with a big group of the best Cancer researchers..  I will be attending as a Patient - Advocate, which means I have to give a presentation.  But I will also try to attend all related sessions and make notes to share.  Here is a link to the conference info..  http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

    Ron

  • GSRon
    GSRon Member Posts: 1,303 Member
    GSRon said:

    AACR info

    OK, here is a bit more info on the 2014 AACR Conference.  This is a huge annual conference with a big group of the best Cancer researchers..  I will be attending as a Patient - Advocate, which means I have to give a presentation.  But I will also try to attend all related sessions and make notes to share.  Here is a link to the conference info..  http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

    Ron

    A good read on.. Immune

    A good read on.. Immune Checkpoint Inhibitors

    http://www.washingtonpost.com/national/health-science/new-therapies-raise-hope-for-a-breakthrough-in-tackling-cancer/2014/02/14/b4f8e4fc-8dad-11e3-95dd-36ff657a4dae_story.html

    PD-1  PDL-1...

    Soon we hope..!

    Ron

  • BDS
    BDS Member Posts: 172
    Are fruit flies the key in the fight against cancer?

    Ok this has nothing to do with RCC but it's really cool - watch this - BDS

    http://www.cbsnews.com/videos/are-fruit-flies-the-key-in-the-fight-against-cancer/

  • NanoSecond
    NanoSecond Member Posts: 653
    BDS said:

    Are fruit flies the key in the fight against cancer?

    Ok this has nothing to do with RCC but it's really cool - watch this - BDS

    http://www.cbsnews.com/videos/are-fruit-flies-the-key-in-the-fight-against-cancer/

    Interesting

    Actually, it did have one oblique connection to the treatment of RCC.  One of the drugs that they determined would be effective against his thyroid cancer was Nexavar (Sorafenib)...

  • BDS
    BDS Member Posts: 172
    Nivolumab

     

    Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN.  Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an  approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS  

     

     

     

    *** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way.  I would really appreciate a little bit of discretion. – Thank you        

     

  • sblairc
    sblairc Member Posts: 585 Member
    BDS said:

    Nivolumab

     

    Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN.  Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an  approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS  

     

     

     

    *** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way.  I would really appreciate a little bit of discretion. – Thank you        

     

    Getting the drug outside of clinical trials?

    Are there any exceptions for getting the drug outside of clinial trials? I was just wondering if you can get experimental medication for compassionate reasons. 

  • i_love_my_dad
    i_love_my_dad Member Posts: 20
    BDS said:

    Nivolumab

     

    Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN.  Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an  approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS  

     

     

     

    *** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way.  I would really appreciate a little bit of discretion. – Thank you        

     

    I think it can hardly be

    I think it can hardly be approved for kidney cancer soon. But can it be approved for Melanoma earlier? I think people can reach it as long as it is FDA approved, no matter for which kind of cancer.  

  • Darron
    Darron Member Posts: 310 Member
    sblairc said:

    Getting the drug outside of clinical trials?

    Are there any exceptions for getting the drug outside of clinial trials? I was just wondering if you can get experimental medication for compassionate reasons. 

    Not easy

    I, like many, am still taking Nivolumab after being declared cancer freeze in my Jan 2 scan. The original trial was rinstop treatment at NED. That was amended to try and establish a maintenance dosing protocol. I think it is moving quicker than originally thought, but still not quick enough!

    I had asked if it is possible to get back in the drug if I went NED, was dropped, then had a recurrence. I was told that I could not go back in the trial, but I could apply to the FDA for an individual liscence vs. Under the trial licence, but it would be difficult. Also, the coat would most likely not be covered on insurance, or trial. It sounded like a dead end.

    That is why you will read about dictors working the trial and keeping their patients on the drug as long as possible

  • yoricks
    yoricks Member Posts: 3
    A year after the original

    A year after the original post, if I were to summarize where we are now:

    1.       No new treatments were approved or a positive Phase III trial completed.

    2.       Tivozanib and Dovitinib, which were in final stages, failed.

    3.       We still have 4 new treatments in Phase III clinical trials:

    A.      Cabozantinib – Exelixis.

    B.      Nivolumab  -BMS

    C.      IMA901 -  Immatics

    D.      AGS 003 – Argos

     

    We have of course dozens of phase I and II trials which need a separate cover.

    Did I get it right?

  • yoricks
    yoricks Member Posts: 3
    Novel treatments in Phase

    Novel treatments in Phase II:

     

    1.      RO 4929097

    Roche

     

    2.      BEZ 235

    Novartis

     

    3.      MK 2206

    Merck

     

    4.      Pidilizumab/ CT 011

    CureTech

     

    5.      Anlotinib

    Jiangsu Chia-tai Tianqing Pharmaceutica

     

    6.      Carfilzomib

    Onyx Therapeutics, Inc.

     

    7.      Bortezomib/ Velcade

    Millennium Pharmaceuticals

     

    8.      ASONEP

    Lpath, Inc.

     

    9.      TH 302

    Threshold Pharmaceuticals

     

    10.  TRC 105

    TRACON Pharmaceuticals 

     

    11.  Trebananib/ AMG 386

    Amgen

     

    12.  Famitinib

    China

     

    13.  Lipotecan/TLC388

    Taiwan Liposome Company 

     

    14.  Dalantercept

    Acceleron Pharma, Inc.

     

    15.  AZD 2014

    AstraZeneca

     

    16.  LY2510924

    Eli Lilly

     

    17.  MPDL3280A

    La Roche

     

    18.  GDC 0980

    La Roche/Genentech

     

    19.  Tasquinimod/ ABR-215050, CID 54682876

    Ipsen

     

    20.  INC280

    Novartis/Incyte

     

    21.  MK 3475

    Merck

     

    22.  RX 0201

     

    Rexahn

  • GSRon
    GSRon Member Posts: 1,303 Member
    yoricks said:

    Novel treatments in Phase

    Novel treatments in Phase II:

     

    1.      RO 4929097

    Roche

     

    2.      BEZ 235

    Novartis

     

    3.      MK 2206

    Merck

     

    4.      Pidilizumab/ CT 011

    CureTech

     

    5.      Anlotinib

    Jiangsu Chia-tai Tianqing Pharmaceutica

     

    6.      Carfilzomib

    Onyx Therapeutics, Inc.

     

    7.      Bortezomib/ Velcade

    Millennium Pharmaceuticals

     

    8.      ASONEP

    Lpath, Inc.

     

    9.      TH 302

    Threshold Pharmaceuticals

     

    10.  TRC 105

    TRACON Pharmaceuticals 

     

    11.  Trebananib/ AMG 386

    Amgen

     

    12.  Famitinib

    China

     

    13.  Lipotecan/TLC388

    Taiwan Liposome Company 

     

    14.  Dalantercept

    Acceleron Pharma, Inc.

     

    15.  AZD 2014

    AstraZeneca

     

    16.  LY2510924

    Eli Lilly

     

    17.  MPDL3280A

    La Roche

     

    18.  GDC 0980

    La Roche/Genentech

     

    19.  Tasquinimod/ ABR-215050, CID 54682876

    Ipsen

     

    20.  INC280

    Novartis/Incyte

     

    21.  MK 3475

    Merck

     

    22.  RX 0201

     

    Rexahn

    Immunotherapy...   Check out

    Immunotherapy...   Check out this video.. it is an hour long.. pull up a chair..

     

    https://www.youtube.com/watch?v=XGeqAEr1RnE&list=UUIRzxohZ6SbwsPqHFQGMJ7A

     

    Ron

  • GSRon
    GSRon Member Posts: 1,303 Member
    GSRon said:

    Immunotherapy...   Check out

    Immunotherapy...   Check out this video.. it is an hour long.. pull up a chair..

     

    https://www.youtube.com/watch?v=XGeqAEr1RnE&list=UUIRzxohZ6SbwsPqHFQGMJ7A

     

    Ron

    Bump..!

    Bump..!

  • Galrim
    Galrim Member Posts: 315 Member
    GSRon said:

    Bump..!

    Bump..!

    We need stickies in these forums

    But I have mailed the moderators about this to no avail...

    /G

  • GSRon
    GSRon Member Posts: 1,303 Member
    Galrim said:

    We need stickies in these forums

    But I have mailed the moderators about this to no avail...

    /G

    I agree.. a sticky on this

    I agree.. a sticky on this one would be a good thing... in the mean time.. have to "bump" it every now and then...

    Ron

  • CSN_Rowan
    CSN_Rowan Member Posts: 87
    Galrim said:

    We need stickies in these forums

    But I have mailed the moderators about this to no avail...

    /G

    Hi Galrim,
    I'm actually

    Hi Galrim,

    I'm actually looking in to creating a sticky for this right now, and if there is a reason that we can't easily put a sticky on this board we'll let you know. Thank you for your continuing support of new members!

    Rowan

    CSN Support Team

  • GSRon
    GSRon Member Posts: 1,303 Member
    CSN_Rowan said:

    Hi Galrim,
    I'm actually

    Hi Galrim,

    I'm actually looking in to creating a sticky for this right now, and if there is a reason that we can't easily put a sticky on this board we'll let you know. Thank you for your continuing support of new members!

    Rowan

    CSN Support Team

    Awesome..!
    Thanks..!
    Ron

    Awesome..!

    Thanks..!

    Ron

  • GSRon
    GSRon Member Posts: 1,303 Member
    GSRon said:

    Awesome..!
    Thanks..!
    Ron

    Awesome..!

    Thanks..!

    Ron

    Here are two links.. one is

    Here are two links.. one is an early report on a new combo drug trial..  But a 79% plus response rate is amazing..!!

    http://ecancer.org/news/5738-asco-2014--ipilimumab-with-nivolumab-achieves-long-term-survival-in-advanced-melanoma.php

    And some interesting RCC news..

    http://ireport.cnn.com/docs/DOC-1147923

    Ron

  • GSRon
    GSRon Member Posts: 1,303 Member
    GSRon said:

    Here are two links.. one is

    Here are two links.. one is an early report on a new combo drug trial..  But a 79% plus response rate is amazing..!!

    http://ecancer.org/news/5738-asco-2014--ipilimumab-with-nivolumab-achieves-long-term-survival-in-advanced-melanoma.php

    And some interesting RCC news..

    http://ireport.cnn.com/docs/DOC-1147923

    Ron

    Here is another link from the

    Here is another link from the recent ASCO Conference.  This video tells a broader tale on the Ipi combo with Nivo.  You Southern California people, may want to check out when this combo may show up at City of Hope..  Looks like there may be some difficult side effects, but the rewards should be well worth it..  You know I will be watching this combo..

    http://cancergrace.org/kidney-cancer/2014/07/02/asco_2014_hottest_thing_late_stage_kidney/

    Ron