What’s Coming Down the Pike
Comments
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Thank you!!!GSRon said:First this post needs to be
First this post needs to be back at / near the top.. too important. Also please be aware of AACR.. I will post a link later..
Ron
Wow, this information is amazing. I am literally in tears. My hope for the future of my husband and everyone here is in these promising therapies. Thanks for bumping this post up, especially for us new to the forum. Hope. . .
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No thanks needed.. it is thesblairc said:Thank you!!!
Wow, this information is amazing. I am literally in tears. My hope for the future of my husband and everyone here is in these promising therapies. Thanks for bumping this post up, especially for us new to the forum. Hope. . .
No thanks needed.. it is the "job" of olde farts like me to help all I can. Keep in mind some of the info is already a bit dated.. but some of us will continue to add the new stuff we hear of...
Here is the AACR link.. http://www.aacr.org/
Be Well All..!!
Ron
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AACR infoGSRon said:No thanks needed.. it is the
No thanks needed.. it is the "job" of olde farts like me to help all I can. Keep in mind some of the info is already a bit dated.. but some of us will continue to add the new stuff we hear of...
Here is the AACR link.. http://www.aacr.org/
Be Well All..!!
Ron
OK, here is a bit more info on the 2014 AACR Conference. This is a huge annual conference with a big group of the best Cancer researchers.. I will be attending as a Patient - Advocate, which means I have to give a presentation. But I will also try to attend all related sessions and make notes to share. Here is a link to the conference info.. http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
Ron
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A good read on.. ImmuneGSRon said:AACR info
OK, here is a bit more info on the 2014 AACR Conference. This is a huge annual conference with a big group of the best Cancer researchers.. I will be attending as a Patient - Advocate, which means I have to give a presentation. But I will also try to attend all related sessions and make notes to share. Here is a link to the conference info.. http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
Ron
A good read on.. Immune Checkpoint Inhibitors
PD-1 PDL-1...
Soon we hope..!
Ron
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Are fruit flies the key in the fight against cancer?
Ok this has nothing to do with RCC but it's really cool - watch this - BDS
http://www.cbsnews.com/videos/are-fruit-flies-the-key-in-the-fight-against-cancer/
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InterestingBDS said:Are fruit flies the key in the fight against cancer?
Ok this has nothing to do with RCC but it's really cool - watch this - BDS
http://www.cbsnews.com/videos/are-fruit-flies-the-key-in-the-fight-against-cancer/
Actually, it did have one oblique connection to the treatment of RCC. One of the drugs that they determined would be effective against his thyroid cancer was Nexavar (Sorafenib)...
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Nivolumab
Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN. Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS
*** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way. I would really appreciate a little bit of discretion. – Thank you
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Getting the drug outside of clinical trials?BDS said:Nivolumab
Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN. Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS
*** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way. I would really appreciate a little bit of discretion. – Thank you
Are there any exceptions for getting the drug outside of clinial trials? I was just wondering if you can get experimental medication for compassionate reasons.
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I think it can hardly beBDS said:Nivolumab
Unfortunately, due to the demands of work and family I have become more of a lurker than an active member here at CSN. Since the failure of Tivozanib to gain FDA approval it seems to me that the pharmaceutical companies have not been issuing very many press releases or news stories about the latest treatments in renal cell carcinoma. So unfortunately, I have not had much to add to the post of “What’s coming down the Pike”. However, on February 27th I had a meeting with my oncologist who has been running clinical trials with BMS-936558/Nivolumab. We had a frank and honest discussion about when the FDA would approve Nivolumab. What my oncologist has informed me is that her BMS reps do not expect Nivolumab to be FDA approved for renal cell until 2016. Many of you I am sure have read internet stories and were hoping for an approval date as early as the end of 2014 or the beginning of 2015. However, this is probably not the case; I trust what my oncologist is telling me. Sorry, if I am the bearer of bad news. - BDS
*** Now please, Oh please do not directly discuss this post with your doctors. I have a frank and honest relationship with my oncologist and I would like to keep it that way. I would really appreciate a little bit of discretion. – Thank you
I think it can hardly be approved for kidney cancer soon. But can it be approved for Melanoma earlier? I think people can reach it as long as it is FDA approved, no matter for which kind of cancer.
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Not easysblairc said:Getting the drug outside of clinical trials?
Are there any exceptions for getting the drug outside of clinial trials? I was just wondering if you can get experimental medication for compassionate reasons.
I, like many, am still taking Nivolumab after being declared cancer freeze in my Jan 2 scan. The original trial was rinstop treatment at NED. That was amended to try and establish a maintenance dosing protocol. I think it is moving quicker than originally thought, but still not quick enough!
I had asked if it is possible to get back in the drug if I went NED, was dropped, then had a recurrence. I was told that I could not go back in the trial, but I could apply to the FDA for an individual liscence vs. Under the trial licence, but it would be difficult. Also, the coat would most likely not be covered on insurance, or trial. It sounded like a dead end.
That is why you will read about dictors working the trial and keeping their patients on the drug as long as possible
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A year after the original
A year after the original post, if I were to summarize where we are now:
1. No new treatments were approved or a positive Phase III trial completed.
2. Tivozanib and Dovitinib, which were in final stages, failed.
3. We still have 4 new treatments in Phase III clinical trials:
A. Cabozantinib – Exelixis.
B. Nivolumab -BMS
C. IMA901 - Immatics
D. AGS 003 – Argos
We have of course dozens of phase I and II trials which need a separate cover.
Did I get it right?
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Novel treatments in Phase
Novel treatments in Phase II:
1. RO 4929097
Roche
2. BEZ 235
Novartis
3. MK 2206
Merck
4. Pidilizumab/ CT 011
CureTech
5. Anlotinib
Jiangsu Chia-tai Tianqing Pharmaceutica
6. Carfilzomib
Onyx Therapeutics, Inc.
7. Bortezomib/ Velcade
8. ASONEP
Lpath, Inc.
9. TH 302
Threshold Pharmaceuticals
10. TRC 105
TRACON Pharmaceuticals
11. Trebananib/ AMG 386
Amgen
12. Famitinib
China
13. Lipotecan/TLC388
Taiwan Liposome Company
14. Dalantercept
Acceleron Pharma, Inc.
15. AZD 2014
AstraZeneca
16. LY2510924
Eli Lilly
17. MPDL3280A
La Roche
18. GDC 0980
La Roche/Genentech
19. Tasquinimod/ ABR-215050, CID 54682876
Ipsen
20. INC280
Novartis/Incyte
21. MK 3475
Merck
22. RX 0201
Rexahn
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Immunotherapy... Check outyoricks said:Novel treatments in Phase
Novel treatments in Phase II:
1. RO 4929097
Roche
2. BEZ 235
Novartis
3. MK 2206
Merck
4. Pidilizumab/ CT 011
CureTech
5. Anlotinib
Jiangsu Chia-tai Tianqing Pharmaceutica
6. Carfilzomib
Onyx Therapeutics, Inc.
7. Bortezomib/ Velcade
8. ASONEP
Lpath, Inc.
9. TH 302
Threshold Pharmaceuticals
10. TRC 105
TRACON Pharmaceuticals
11. Trebananib/ AMG 386
Amgen
12. Famitinib
China
13. Lipotecan/TLC388
Taiwan Liposome Company
14. Dalantercept
Acceleron Pharma, Inc.
15. AZD 2014
AstraZeneca
16. LY2510924
Eli Lilly
17. MPDL3280A
La Roche
18. GDC 0980
La Roche/Genentech
19. Tasquinimod/ ABR-215050, CID 54682876
Ipsen
20. INC280
Novartis/Incyte
21. MK 3475
Merck
22. RX 0201
Rexahn
Immunotherapy... Check out this video.. it is an hour long.. pull up a chair..
https://www.youtube.com/watch?v=XGeqAEr1RnE&list=UUIRzxohZ6SbwsPqHFQGMJ7A
Ron
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Bump..!GSRon said:Immunotherapy... Check out
Immunotherapy... Check out this video.. it is an hour long.. pull up a chair..
https://www.youtube.com/watch?v=XGeqAEr1RnE&list=UUIRzxohZ6SbwsPqHFQGMJ7A
Ron
Bump..!
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Hi Galrim,Galrim said:We need stickies in these forums
But I have mailed the moderators about this to no avail...
/G
I'm actuallyHi Galrim,
I'm actually looking in to creating a sticky for this right now, and if there is a reason that we can't easily put a sticky on this board we'll let you know. Thank you for your continuing support of new members!
Rowan
CSN Support Team
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Awesome..!CSN_Rowan said:Hi Galrim,
I'm actuallyHi Galrim,
I'm actually looking in to creating a sticky for this right now, and if there is a reason that we can't easily put a sticky on this board we'll let you know. Thank you for your continuing support of new members!
Rowan
CSN Support Team
Thanks..!
RonAwesome..!
Thanks..!
Ron
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Here are two links.. one isGSRon said:Awesome..!
Thanks..!
RonAwesome..!
Thanks..!
Ron
Here are two links.. one is an early report on a new combo drug trial.. But a 79% plus response rate is amazing..!!
And some interesting RCC news..
http://ireport.cnn.com/docs/DOC-1147923
Ron
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Here is another link from theGSRon said:Here are two links.. one is
Here are two links.. one is an early report on a new combo drug trial.. But a 79% plus response rate is amazing..!!
And some interesting RCC news..
http://ireport.cnn.com/docs/DOC-1147923
Ron
Here is another link from the recent ASCO Conference. This video tells a broader tale on the Ipi combo with Nivo. You Southern California people, may want to check out when this combo may show up at City of Hope.. Looks like there may be some difficult side effects, but the rewards should be well worth it.. You know I will be watching this combo..
http://cancergrace.org/kidney-cancer/2014/07/02/asco_2014_hottest_thing_late_stage_kidney/
Ron
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