Votrient Side Effects

kelbert said:

Blood pressure

Hello Everyone,

I was just wondering if anyone on this thread has had a good response on Votrient without any known problems with high blood pressure?

What would the symptoms of high blood pressure be? My Dad has been feeling really terrible over the last few days, describing feeling really really dizzy, which can come on all of a sudden, he says it feels like the worst hangover ever except without the enjoyment of having a drink! Thankyou.

Kelly x

Kelly,

As I stated in my response to Ron, John (one putt) is on a Nivolumab/Votrient trial. He has been very fortunate with his response, but we don't know if Nivolumab is the reason; if Votrient is the reason; or if the combo is the reason.

But note he has not experienced high blood pressure, and--while I realize elevated blood pressure--is often indicative of Vortrient's success, I don't think it is always the case.But do as Tex says and invest in the bp cuff. I DO NOT have cancer, but I do have high blood pressure. I was diagnosed many years ago when I started experiencing headaches and dizziness. So while high blood pressure is the silent killer, headaches and dizziness often accompany it.

Good luck to you and your dad. Chins up!

NanoSecond said:

Votrient and Blood Pressure

Kelly,

I do not take Votrient and so have not paid very close attention to all its side effects.  And while I generally agree with Tex - his pointed statement about high blood pressure got me motivated to look more deeply into the issue.

This is what I found:

"Hypertension (systolic blood pressure ≥150 or diastolic blood pressure ≥100 mm Hg) and ​hypertensive crisis were observed in patients treated with Votrient. Blood pressure should be well-controlled prior to initiating Votrient. Hypertension occurs early in the course of treatment (40% of cases occurred by Day 9 and 90% of cases occurred in the first 18 weeks). ​Blood pressure should be monitored early after starting treatment (no longer than one week) and frequently thereafter to ensure blood pressure control. Approximately 40% of patients who received Votrient experienced hypertension. ​Grade 3 hypertension was reported in 4% to 7% of patients receiving Votrient [see Adverse Reactions (6.1)]."

The above and lots more important information can be found here:

http://www.drugs.com/pro/votrient.html

Hope you found that helpful.  And, in particular, sufficient reason to wait until jumping to any conclusions about whether or not Votrient is working.

Hi All..!  As an aside note.. the last few days I have been real busy doing something for ME... that is racing my little motorpickle..  What is interesting is that most of the side effects kind of held off, until I got home... then bang..  My take is that I was running on adrenaline.. and thus was able to function at a pretty high level for the two plus days..!   When I got home, almost instantly I had sweats.. and diarrhea...  Took a warm shower and drank a bunch of water, then slept..  My BP was not overly high...   Today mostly had the diarrhea.. took an Imodium and am a lot better...

As an extra aside, talked to a pal at the track, he has E.C.  Esophogial..? (can't spell that word..)..  So it does not take much to find out lots of people I know have the Crud in some version or another... sigh..

Just hope it works for everyone on it..!

Cheers.!!

Ron

foxhd said:

Keep on riding

Keep on riding Ron. People speak of my attitude but I don't have anything over you. Maybe it is the motorcycles? I do know that I won't be racing. I will be out camping with my bike for most of June. Take care of yourself. Fox.

Yes, Fox.. I do think having some important hobby in our lives helps us to move forward..  Does not matter what the hobby is.. it helps..  But then, I do also think us bike guys (and gals) have a special bond with the open air and we see the countryside a bit differently than others..  You take care as well... keep riding..  Both of my street bikes are down for repairs... I need to get to the garage and fix them..  The olde bikes often need repairs.. they NEED me..!

To the rest of you.. keep doing what you love..   The last few days there were times that I almost forgot about the RCC...  I felt "normal" for a while..  I hope this works for all of you as well...

Be Well...

Ron

BLKJAK said:

One week on Votrient

I've been on Votrient for a week now. Week 2 begins tonight for me. I have had my blood pressure go up a bit, but that's about it for side effects. I have a bit of loose stool, but that might be attributed to the Buffalo Wing Pizza I had for dinner. TMI perhaps? If it continues, it will be the second side effect from Votrient. So far, so good. I hope the other side effects never present themselves.

I have been using the MAARS program and hopefully that is helping to get this damn cancer out of my body. I haven't been allowing cancer to get the best of me. I show it no respect and it needs to know it's not welcome here. I really want to prove the first oncologist wrong and live a nice long life.

Please go right on, full steam ahead, and do just what you're planning.

moe1131 said:

Votrient

 BLKJAK,  glad to hear you don't have too many side effects from the Votrient. I start Votrient in a few weeks I just had surgery to remove a tumor so I have to wait until I'am healed. I was wondering what dosage you are on I'am suppost to start at 800mg 4tablets which I plan to take at night. I have been on the site and reading about the side effects of the Votrient which has been very helpful so I thank all, and hope I will not have too many.I have good blood pressure so if it goes up a little i'am not to worried. I don,t have renal cancer I have Leiomyosarcoma cancer of the smooth muscle some people with my type of cancer have had good results on the  Votrient. I'm hopeful and thankful there is something else to try besides chemo. thanks 

Hi all, Had my CT scan last Tuesday, saw my oncologist thursday the scan were good all nodules are shrinking, I haven't got measurements my oncologist show us the scan so we could see the difference. As for side effect still trying to get my BP under control, a little bit of diarrhea sometimes and slightly sore feet. I take 800mg mid morning and still work full time.

BLKJAK said:

Hi Moe

I am taking 4 tablets (800mg) every night at bed time. I have started to allow myself a little TV time to settle in before starting the MAARS audio program. I don't have any nausea that I know of and have yet to have a side effect other than the rise in blood pressure that I can absolutely say is because of Votrient. Today I have some soreness in my lips. I don't know what that's about but am applying Carmex to treat it.

Good luck to you! Stay positive!

Hi BLKJAK, thanks for getting back to me good to hear your still at 800mg I will look into the MAARS not that familiar with that program. It helps to hear how other cancer patients are doing on this site. I will let you know how I'm doing once I start the Votrient I think in a week I'am ready and very positive this drug will help. Do you still work ?

BLKJAK said:

Agreed

I agree on the bad days comment. I was doing great for over a week, then yesterday I had pain in my left side and blood in my urine again. That took the wind out of my sails. A good night's rest works wonders though. I can't let it get me down.

Blkjak perhaps you an a uti infection.  Please be sure to see your GP and also maybe a call to your oncologist?     I hope you feel better!  Keep up the positive attitude, a good looking person such as yourself won't have it any other way!!

BLKJAK said:

Still working

Yep, I am still working. I am a network engineer so my work doesn't involve much lifting or moving. It's definiitely more mental than physical and I'm grateful for that. The owner of the company is very compassionate about my situation. He told me that if I am tired I should go home and take a nap. I am pretty lucky overall.

Hello BLKJAK, I plan to continue to work I work at a hospital so I also have very understanding supervisors and team members who are great.

Sorry to hear about the blood in your urine, but it very well could be UTI I had a few of those and there awful.

 What I have gathered from this site and the Sarcoma Allinnce site sounds like many have had to have their dosage reduced while on this drug, cannot sustain the 800mg. I have to question whether I should start out at 800 mg ? My Oncologist does not have any other patient on this drug. Please keep us posted on how your doing stay strong it's another bump in in the road. I won't start thr drug for another three weeks.