CA 125 elevated due to endometriosis? - how much?

HusbandOfAnAngel said:

Hi
Her Dr said that he was concerned about the elevated CA 125 and he is referring her to another surgeon at the University Hospital. This cyst was not there 4 months ago, then he discovered it 2 months ago just before her last IVF cycle but said he was not worried about it at that time and that he would "keep an eye on it". Then, just this week on our last visit he took another U/S and saw that it was still there. It is 20mm and it has an "irregular shape". We are now waiting for the referral appointment. I think this will end up with another laparoscopic surgery, since I believe there is no definitive way to diagnose this growth without looking at it.

HusbandOfAnAngel said:

Thank you
Many thanks for Everyone for the support and encouragement. You are wonderful people.

sleepy hollow said:

CA 125
hello - I found your answer very interesting on the CA 125 - I am worried since my CA 125 has jumped to 55 - and had been around 29 for a few months. I also have just found that my thyroid is acting up again and I am hypothyroid and I have thyroid antibodies - this is an auto immune condition - can you tell me some of the things that can raise the CA 125 - can hypothyroidism do this and have you ever heard of that? thank you for whatever insight you can provide. You mentioned bladder infection , flu cold - have you experienced with yourself or others that the CA 125 can rise for all these reasons?

I googled and came across this post.... my wife has had endometriosis since before we met. She had laproscopic surgery done 12 years ago. We had our only child as soon as we got married. On and off she would hurt during the periods. It has gotten worse this year and eventually she got it checked 6-7 weeks ago. Her CA125 was high on Nov, doctor thought it was due to the endometrioisis. She went for follow up this past Thursday and the CA125 shows increased levels from last month. The doctor is now worried. Not sure if the fact that both tests were around the last days of period cycle along with endometriosis have anything to do with it. Last month the ultrasound did not show anything. Today my wife is going through the CT scan with Barium. Have surgery scheduled for Friday if it is endometriosis related. I hope it is.

Loved the guy's post because we are supposed to be the strong ones and it is strange how strong the women are. Real proud of my wife. Sometimes it is hard to express that. I have been very quite last 3 days and not sure if she is taking that as I don't care or knows that I am struggling with her situation and a hot mess due to it. I have this sinking feeling and glad that I found this avenue to post and share some of my thoughts and feelings.

Pray for us.

Hi

My radiology reports says that I have an endometriotic cysts of 7.9 * 6.5 cm in right ovary. I was suggested to go for CA125 test. My CA125 report shows the Tumor marker 46.8 which according to the normal range mentioend in the report (2.0 - 35.0) is high.

Does it conclude that I have a cancer??

Many Thanks

Risha

Cafewoman53 said:

Hello
Please do not borrow trouble, the ca125 is not a good marker to diagnose ovarian cancer. It can be elevated for anyone of the reasons you stated.this is not medical advice but yes it's possible your wife does not have cancer.
It is not easy but take a breath and wait to hear from your dr.
If the news is bad you will deal with whatever it is.
Good luck
Colleen

Hi!

 My mother has just got CA125 test. Its 273! Is it supposed to ovarian cancer for sure? She has endometriosis. Fibrinoids in the uterus(enlarged). She has diabetes, hypertension.. Last measured blood pressure was 150/90. Please suggest Something good we are tensed.I hope this will help us for some extent.

Dear amfietobias, the doctors will need to do testing to see what you really do have, and I hope it is not some cancer.  If it is, please be sure to work with a gynecologic oncologist as they specialize in gyn cancers.  As for this thread, sadly it is an older post and some of the beautiful ladies are no longer with us.  

Please let us know when they complete the testing.  I am hoping it is nothing.

Dear “star1310”

Although I don’t know anything about “Endometriosis”, I have looked up some references that may be helpful.  I wouldn’t begin to know why your CA-125 is elevated, but when it is this high, it certainly needs to be explained.  Normally our CA-125 can range up to 35 and be considered “normal”, but there are other times when it is elevated because of infection, etc.  However, a gynecological oncologist is the best person to take your case and find out what your problem is.  I did look up the equivalent in inches for the two measurements you gave us.

 They are as follows:  3.6 cm = 1.41732283 inches…4 cm = 1.57480315 inches.

Anytime we have something “inside” that isn’t supposed to be there, it is a cause for concern.  So hopefully you will find a well-qualified doctor who is thoroughly familiar with Endometriosis.  While I have given references that include the possibility of cancer, please don’t assume that whatever the problem is starts with a “big C”.  I do know that there are others on this forum who have this problem, and hopefully some will come forward to help you.  Moreover, the next time you write, why not a “new topic forum” on this link start?  The one you are using doesn’t have a lot of active participants.

Hoping you will soon find answers to all your questions, and that things can be resolved quickly.

Loretta

Peritoneal Carcinomatosis/Ovarian Cancer Stage IV

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1.     https://www.mayoclinic.org/diseases-conditions/endometriosis/symptoms-causes/syc-20354656

“Overview - Endometriosis

Endometriosis (en-doe-me-tree-O-sis) is an often painful disorder in which tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus. Endometriosis most commonly involves your ovaries, fallopian tubes and the tissue lining your pelvis. Rarely, endometrial tissue may spread beyond pelvic organs.

With endometriosis, displaced endometrial tissue continues to act as it normally would — it thickens, breaks down and bleeds with each menstrual cycle. Because this displaced tissue has no way to exit your body, it becomes trapped. When endometriosis involves the ovaries, cysts called endometriomas may form. Surrounding tissue can become irritated, eventually developing scar tissue and adhesions — abnormal bands of fibrous tissue that can cause pelvic tissues and organs to stick to each other.

Endometriosis can cause pain — sometimes severe — especially during your period. Fertility problems also may develop. Fortunately, effective treatments are available…”

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2.     https://www.medicinenet.com/endometriosis/article.htm

“…What is endometriosis?

Endometriosis is the abnormal growth of endometrial tissue similar to that which lines the interior of the uterus, but in a location outside of the uterus. Endometrial tissue is shed each month during menstruation. Areas of endometrial tissue found in ectopic locations are called endometrial implants. These lesions are most commonly found on the ovaries, the Fallopian tubes, the surface of the uterus, the bowel, and on the membrane lining of the pelvic cavity (i.e. the peritoneum). They are less commonly found to involve the vagina, cervix, and bladder. Rarely, endometriosis can occur outside the pelvis. Endometriosis has been reported in the liver, brain, lung, and old surgical scars. Endometrial implants, while they may become problematic, are usually benign (i.e. non-cancerous)…”

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3.     https://www.cancer.gov/news-events/cancer-currents-blog/2018/liquid-biopsy-screening-test-endometrial-ovarian

“Study Shows Experimental Screening Test Can Detect Endometrial and Ovarian Cancers

May 2, 2018, by NCI Staff

PapSEEK detects genetic alterations in DNA that ovarian and endometrial tumors have shed into the uterus, cervix, and blood (plasma).

Credit: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

 Researchers have shown that an experimental screening test can detect some endometrial and ovarian cancers at their early, more treatable stages. The test, called PapSEEK, is a type of liquid biopsy that identifies cancer-related alterations in DNA obtained from fluids collected during a routine Pap test. 

 In the NCI-funded study, which used Pap test samples from women already diagnosed with cancer, PapSEEK correctly identified most women with endometrial cancer and one-third of women with ovarian cancer. The test's ability to accurately identify cancer (its sensitivity) improved when the researchers also tested DNA collected from blood and other tissues.

 Sudhir Srivastava, Ph.D., M.P.H., of NCI's Division of Cancer Prevention, called the findings "a good start" for developing an effective screening test for early-stage endometrial and ovarian cancer. "This lays the foundation for future studies," added Dr. Srivastava, who was not involved in the study.

 The retrospective study was published March 21 in Science Translational Medicine. Additional prospective studies are needed to determine whether PapSEEK can correctly identify women with cancer who have not yet been diagnosed, the investigators noted…”

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4.    https://www.cancer.gov/types/uterine/patient/endometrial-treatment-pdq

“Endometrial Cancer Treatment (PDQ®)–Patient Version

Sections

General Information About Endometrial Cancer

Key Points

• Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium.
• Obesity and having metabolic syndrome may increase the risk of endometrial cancer.
• Taking tamoxifen for breast cancer or taking estrogen alone (without progesterone) can increase the risk of endometrial cancer.
• Signs and symptoms of endometrial cancer include unusual vaginal bleeding or pain in the pelvis.
• Tests that examine the endometrium are used to detect (find) and diagnose endometrial cancer.
• Certain factors affect prognosis (chance of recovery) and treatment options.

Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium.

The endometrium is the lining of the uterus, a hollow, muscular organ in a woman’s pelvis. The uterus is where a fetus grows. In most nonpregnant women, the uterus is about 3 inches long. The lower, narrow end of the uterus is the cervix, which leads to the vagina…”

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