Tegafur / Uracil Experience Anyone ?

ssrik
ssrik Member Posts: 8
edited August 2012 in Colorectal Cancer #1
Our ONC has prescribed Tegafur URacil Oral tablet after 5 cycles of 5fu/Irinotecan combination is complete..
has any one has any idea or experience of possible sideeffects with Tegafur .
My pateint has been facing reduced urine output since she has been on this...
Wonder if it is a sideeffect of chemo or something else

She has been using aldactone for 2 weeks now as advised. not sure if use aldactone would introduce urine retention ?

Thanks for your response..
rgds
SS

Comments

  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #2
    be patient, I think tanstafl is across this
    Goodluck and thanks for posting.

    Hugs,
    Pete
  • ssrik
    ssrik Member Posts: 8
    #3
    pete43lost_at_sea said:

    be patient, I think tanstafl is across this
    Goodluck and thanks for posting.

    Hugs,
    Pete

    thanks pete
    Thanks Pete for words of encouragement.. Have you heard of tegafur ?

    any one else has experience with tegafur ?
  • Annabelle41415
    Annabelle41415 Member Posts: 6,742 Member
    #4
    Sorry
    I'm not familiar with either but wishing you the best.

    Kim
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #5
    CKD
    We've used a immunochemo plan with UFUR/UFT for over 2 years, containing 300 mg then 400 mg of tegafur per day. Click [tanstaafl] for more.

    I would be surprised if it was the tegafur with everything else possibly going on, but we also use a number of supportive nutritional measures. I would be asking the doctor(s) to review treatments, historical lab data, kidney function, any (pre)diabetes, and cumulative damage from chemo, the steroid, live tumors, and disintegrating tumors over the past several months. Patients can accumulate a lot of damage before the damage becomes obvious, sometimes from a single event, that surfaces months later.

    Kidney support related antioxidants that we have used include riboflavin (B2) and Life Extension's kidney disease article that includes pyridoxamine, CoQ10, silymarin, resveratrol, and lipoic acid.
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #6
    ssrik said:

    thanks pete
    Thanks Pete for words of encouragement.. Have you heard of tegafur ?

    any one else has experience with tegafur ?

    i have read about it and studied, but had not first hand experie
    i just had a quick read, i have come across it in various studies over the last few years, its not on my shopping list!

    it maybe helpful, hard to say.

    hugs,
    pete

    ps it helped these colorectals get a few more breathes, but its not the cure!

    http://www.ingentaconnect.com/content/maney/joc/2012/00000024/00000004/art00005

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