Looking for comments about Jemperli/dostarlimab

KHoltgraver

I am a 73-year-old female, diagnosed with an aggressive form of endometrial cancer (EC), type IIIC1 dMMR. I had a complete hysterectomy last fall with no obvious signs of spread to nearby organs but did have one lymph node show microsized cancer cells. I've since received 7 infusions of Jemperli (6 infusions with paxitaxil and carboplatin) plus a single infusion alone of Jemperli. I also had 25 radiation sessions to the base of my pelvis. I am currently considered without disease but I am also aware that EC has a nasty habit of recurring. Recently, at what was to be my 8th Jemperli infusion, my doctors ultimately determined that I had developed complete cortisol insufficiency. In short, the Jemperli trashed my adrenal glands and I will have to take hydrocortisone for the rest of my life. Jemperli has many known side effects but I'm having difficulty determining if the side effects will continue to add up if I continue the immunotherapy. Does anyone have any information to share about this? TIA.

Forherself

I just wanted to say we are here for you. I had serous endometrial cancer 7 years ago with no recurrence so there is hope. I did not take those medications, but there are women here who have and I hope they comment. Did your doctors reduce the dose of the Jemperli? Some women here have said that is what they did when side effects were serious. I'm sorry to hear about your adrenal glands. Is it a rare side effect? At least it. is a a doable treatment. Hopefully others will comment soon. Zsazsa1 had a similar case to you. I don't know if she took Jemperli though. She is 7. years out too with no recurrence.

abume

Sorry to hear of your reaction to Jemperli. I am also on Jemperli for maintenance of serous carcinoma. I was originally diagnosed with carcinosarcoma a more aggressive form of endometrial cancer. Jemperli was included in my 9 infusions for chemo. Then I was moved to Jemperli alone for maintenance. First infusion was uneventful. A week after the 2nd infusion I developed a rash in a few spots on my body. The itching was so bad that I ended up in the ER. The dosage has since been reduced by 50% and infusion changed from every 6 weeks to 3 weeks. I just got it 6 days ago, with allergy drugs. Keeping my fingers crossed that there is no reaction.

To answer your question, not sure whether Jemperli has a cumulative side effect, however hopefully reducing the dosage by half might help hopefully.

Best of luck!