From the US National Library of Medicine

jason.2835
jason.2835 Member Posts: 337 Member
edited December 2014 in Kidney Cancer #1

I found this as part of a study done between 1989 and 2008.  For those of us who had very small tumors (less than 3 cm), this is extremely hopeful news.  Hope this is interesting.  Here is a link to the page if you want to read the more in depth article, but below is the quick abstract:

 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735023/

RISK OF METASTATIC RENAL CELL CARCINOMA ACCORDING TO TUMOR SIZE

Abstract

Purpose

Recent evidence suggests significantly discordant findings regarding tumor size and the risk of metastases in renal cell carcinoma (RCC). Herein, we present our experience with RCC and evaluate the association between tumor size and risk of metastases in a large cohort of patients.


Methods

Using our prospectively maintained nephrectomy database, we identified 2,691 patients treated surgically for a sporadic renal cortical tumor between 1989 and 2008. Associations between tumor size and synchronous metastases at presentation (M1 RCC) were evaluated with logistic regression models while metastases-free survival following surgery was estimated using the Kaplan-Meier method for 2,367 patients who did not present with M1 RCC and who were followed postoperatively.

Results

Among the 2,691 patients, 162 presented with metastatic RCC. Only 1 of 781 patients with a tumor <3cm had M1 RCC at presentation and tumor size was significantly associated with metastases at presentation (odds ratio 1.25 for each 1cm increase, p<0.001). Among the 2,367 patients who did not present with metastases, 171 developed metastatic disease during a median follow-up of 2.8 years. In this group, only 1 of the 720 patients with RCC <3cm developed a de novo metastases during follow-up. Metastases-free survival was significantly associated with tumor size (hazard ratio 1.24 for each 1cm increase, p<0.001).


Conclusion

In our experience, tumor size is significantly associated with synchronous metastases and asynchronous metastases following nephrectomy. Our results suggest that risk of metastatic disease for patients with tumors <3cm is negligible.

 


Comments

  • icemantoo
    icemantoo Member Posts: 3,361 Member
    #2
    Screening

    A year and one half ago I wrote reflections on my 70th birthday. One of those was that 70 years from now Stage 2,3 and 4 RCC will be eliminated by more advanced screening procedures One of these could be taken from Colon Cancer screening and that is that it should be standard for those of us over 50 to have an abdominal ultrasound which would identify most small Kidney Tumor's in the bud.

     

    Icemantoo

  • jason.2835
    jason.2835 Member Posts: 337 Member
    #3
    icemantoo said:

    Screening

    A year and one half ago I wrote reflections on my 70th birthday. One of those was that 70 years from now Stage 2,3 and 4 RCC will be eliminated by more advanced screening procedures One of these could be taken from Colon Cancer screening and that is that it should be standard for those of us over 50 to have an abdominal ultrasound which would identify most small Kidney Tumor's in the bud.

     

    Icemantoo

    Google nanites

    Below is a link to an article I read about Google developing nanotechnology that would essentially monitor the blood constantly and alert you to chemical changes that occur when cancer forms. Pretty. Amazing. Stuff.  Matches almost exactly a sci-fi story I wrote a few years back haha.  Just shows that new tech is coming.  Soon. 

    http://www.bbc.com/news/technology-29802581

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