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Testosterone recovery after ADT

Georges Calvez
Posts: 442
Joined: Sep 2018

Hi there,

I thought this new publication would add to the knowledge of members.
It seems that testosterone recovery after ADT takes some considerable time and after a time around the nineteen months that I received recovery can take up to two years, but the chance of recovery is better than I thought!
You will have to copy and paste the link as it contains unrecognised characters that stops normal clicking through from working.
https://www.jsm.jsexmed.org/article/S1743-6095(19)30735-0/fulltext

Best wishes,

Georges

VascodaGama's picture
VascodaGama
Posts: 3191
Joined: Nov 2010

This is an interesting study on T after ADT. It could be better if they have listed the correlation between each symptom and the period it exists/is felt. For instance, the intensity of my arthritis pain began lowering when T passed the mark of 56 ng/dL (clinical castration) which was just 3 months since my departure from castration ( T=20 ng/dL), when I was already at the seventh month post the end of effectiveness of the my last 6-month shot of Eligard. One month later I would enter into the normal range of testosterone of 252 ng/dL. In other words, it took me 8 months since the end of the effectiveness of the shot to recover the testosterone from T=1 ng/dL to 252 ng/dL. 

In any case I have my reservation regarding this study's viability when the subject regards the level of testosterone in PCa treatments. I say this because oncologists use lower T to represent castration (<20 ng/dL) and the normal T as >250 ng/dL. In such cases the time it takes to recuperate from castration may be longer. In my experience of 3 Eligard shots (6-month X 3 = 18 months), it took me 8 months to get to oncological normal levels above 250 (9 months to get to levels above 300) sarting from the date of the end of effectiveness of the drug. But it took me just 4 months to reach the normal level after leaving the castration period (T<20).
Along the period of treatment one experiences several symptoms not just due to castration (low testosterone = hypogonadism) but also due to the effects caused by the LHRH agonist in the functioning of the pituitary. Mood change, hot flashes, impared recognition , etc, are symptoms caused directly from the drug. 

Thanks for posting the link. Here is a direct one;

https://www.jsm.jsexmed.org/article/S1743-6095(19)30735-0/fulltext

Best,

VG

 

SV
Posts: 106
Joined: Sep 2010

At the end of ADT would using HCG help? Or would that be too risky? Human chorionic gonadotropin is often used by longterm steroid users with testicle shrinkage to speed up their testosterone recovery when coming off of a cycle. It's very effective for this and can return a man's production of natural testosterone in a few weeks or less.

VascodaGama's picture
VascodaGama
Posts: 3191
Joined: Nov 2010

I know nothing about HCG. Can you provide details on this hormone?

A member in this forum named Rakendra used steroid in body building. You may contact him via CSN mail and inquiring. Here is a link to one of his posts;

https://csn.cancer.org/node/292304

VG

Georges Calvez
Posts: 442
Joined: Sep 2018

Hi there,

HCG is the placental analogue of lutenising hormone aka LH which promotes testicular growth in human males.
Given the links between FSH and the growth of PCa I think I would have to twist Dr Tigger's tail really hard before he would agree to inject me with that stuff just so my nuts would grow! :-)
https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

Best wishes,

Georges

Georges Calvez
Posts: 442
Joined: Sep 2018

Testing,testng

Clevelandguy
Posts: 552
Joined: Jun 2015

Wow, if it was me I think I would stay away from anything that raised Testosterone.  Isn't it bad to raise T levels if you had or have Pca?  I thought you try to keep your T low to slow down the growth of Pca, is that right?

Dave 3+4

 

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