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Hope for Neuropathy‎?

SandiaBuddy's picture
SandiaBuddy
Posts: 1093
Joined: Apr 2017

I came accross this article in abstract form only that may provide some hope for those with neuropathy  (please note that this appears to be a very preliminary mouse study):

 

Oxaliplatin is a cornerstone chemotherapeutic used in the treatment of colorectal cancer, the third leading cause of death in Western countries. Most side effects of this platinum-containing drug are adequately managed in the clinic, although acute and long-term neurotoxicity still severely compromises the quality of life of patients treated with oxaliplatin.We have previously demonstrated that therapeutically relevant concentrations/doses of oxaliplatin lead to a reduction in intracellular pH in mouse dorsal root ganglia neurons in vitro and in vivo and that this alteration sensitizes TRPA1 and TRPV1 channels, which most likely mediate the allodynia associated with treatment. In the present manuscript, we show that oxaliplatin leads to a reduction of intracellular pH by forming adducts with neuronal haemoglobin, which acts in this setting as a proton buffer. Furthermore, we show that FDA-approved drugs that inhibit carbonic anhydrase (an enzyme that is linked to haemoglobin in intracellular pH homeostasis), i.e. topiramate and acetazolamide, revert (i) oxaliplatin-induced cytosolic acidification and TRPA1 and TRPV1 modulation in dorsal root ganglia neurons in culture, (ii) oxaliplatin-induced cytosolic acidification of dorsal root ganglia of treated animals, and (iii) oxaliplatin-induced acute cold allodynia in mice while not affecting OHP-induced cytotoxicity on cancer cells.Our data would therefore suggest that reversal of oxaliplatin-induced cytosolic acidification is a viable strategy to minimize acute oxaliplatin-induced symptoms.

 

https://www.ncbi.nlm.nih.gov/pubmed/31634341

myAZmountain's picture
myAZmountain
Posts: 337
Joined: Apr 2018

Have often wondered if Chelation Therapy would be useful in reducing the amount of Platinum left after chemo.

Annabelle41415's picture
Annabelle41415
Posts: 6531
Joined: Feb 2009

It's too bad that some of the doctors don't read more about the effects of platinum in the human body.  After 5 treatments my concerns about the numbness that never went away after #4 was of no concern to her.  She said is was "just a nuisance."  Well, now I've got permanent neuropathy. 

Kim

SandiaBuddy's picture
SandiaBuddy
Posts: 1093
Joined: Apr 2017

I am lucky to have stopped the oxi after only one dose, and I have almost no residual neuropathy, but if I did, I would likely reseach the possibility of using some meds "off-label" to see if I could benefit.

Annabelle41415's picture
Annabelle41415
Posts: 6531
Joined: Feb 2009

I'm glad you had the sense to stop, and hindsight is always 20/20.  Just wishing my doctor would have listened to me a little more.

Kim

abita's picture
abita
Posts: 821
Joined: Dec 2017

If it goes away, how long does it take? 9 months, a year...?

AnneO1965's picture
AnneO1965
Posts: 149
Joined: May 2019

My doc told me that anything you have after two years you are probably stuck with..

beaumontdave's picture
beaumontdave
Posts: 1063
Joined: Aug 2013

That seems a reasonable measure, mine was mostly gone by 18-20 months............................................................Dave

abita's picture
abita
Posts: 821
Joined: Dec 2017

That is interesting. People ask me because it has been 8 months since my last oxaliplatin. I have no idea and feared that maybe after 8 months it is permanent. I have one finger that is a little numb and feet neuropathy. 

SoCal42
Posts: 78
Joined: Jul 2017

My doc gave me the same time range, mine escalated after treatment ended, then just plateaued kind of permanently after that.

nuc
Posts: 44
Joined: Jun 2019

My wife, luckily decided against the oxaliplatin, but if she had, she would have been supplementing with Glutamine.  Every oncologist should be offering/including it with Folfox/Capox administration.

glutamine (15 g twice a day for seven consecutive days every 2 weeks starting on the day of oxaliplatin infusion). Efficacy of chemotherapy, neurological toxicity, and electrophysiological alterations were assessed. A lower percentage of grade 1–2 peripheral neuropathy was observed in the glutamine group (16.7% versus 38.6%) after two cycles of treatment, and a significantly lower incidence of grade 3–4 neuropathy was noted in the glutamine group after four cycles (4.8% versus 18.2%) and six cycles (11.9% versus 31.8%). By adding glutamine, interference with activities of daily living was lower (16.7% versus 40.9%), and need for oxaliplatin dose reduction was lower (7.1% versus 27.3%). There were no significant between-group differences in response to chemotherapy (52.4% versus 47.8%)

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