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Advanced Cancer and waiting...

bdhilton
Posts: 776
Joined: Jan 2010

 

I've been watching my score go up this year (surgery early 2010 and salvage late 2015).  My PSA is now .310 up from a .207 in March and .210 in July...I continue with a good and mostly plant base diet, which I believe has helped me over the years (outcome could have been aggressive but it hasn’t to date).  Some days I hate it…So, I keep busy (just bought an abandon 40 acre apple orchard that needs lots of TLC)…I do have a couple of cheat days every 3 or 4 months where I’ll eat a bacon cheese burger but I’m pretty consistent with the plant base diet that I incorporate some cold-water fish into…At the end of the day, I’m blessed…Cancer affects all of us differently and those around us.  So, I’ll stay business, stick to my diet, keep a healthy weight and enjoy my time until the doctors say ADT and reevaluate.

 

The best to everyone on their journey…

 

Georges Calvez
Posts: 464
Joined: Sep 2018

Hi there,
I would not say that your score is going up; it might be, on the other hand it might not.
Look how this guy's PSA level fluctuated over a 28 day period and you will realise that your PSA may or may not be showing anything.
Hang on for December, you may get lucky and see it stay level or even fall.
https://www.yananow.org/PSAexperiment.shtml

Best wishes,

Georges

bdhilton
Posts: 776
Joined: Jan 2010

Hi George...thanks for the positive feedback...

VascodaGama's picture
VascodaGama
Posts: 3238
Joined: Nov 2010

Hilton,

Wow … …, that is a big piece of land surely requiring loads of care. I have a fewer number of fruit trees in a 4 acre piece, and each passing year I feel lesser energy to care for it. Working the land with my MF 135 (older than me) has given me trouble too in walking due to a heel spur that it wasn’t there before buying the land. But I am enjoying the produce (fruits and vegetables) grown free of chemicals.

You titled the thread as “advanced cancer” but I think that your case is still localized. Your history since 2010, doesn’t imply a sort of aggressive type of cells in spite of the diagnosed Gleason score 4+3 (7). You still got a chance in eliminating the bandit if you manage to identify the cancerous spots and these lie in an appropriate area to receive spot radiation. This is what I have suggested in your last thread in here;

https://csn.cancer.org/node/319286

The present PSAdt of over 12 months would get you into a PSA of >5.0 (your doctor’s trigger threshold for the next treatment) in almost three years from today. That gives you enough time to explore possibilities in an oligometastatic treatment. They are doing it a JH so that you may inquire them or request your doctor to do so after a PET scan done to locate the spots. ADT will be always valid at any PSA level.

The ORIOLE study;

https://www.medscape.com/viewarticle/918509#vp_1

Best wishes,

VGama

 

bdhilton
Posts: 776
Joined: Jan 2010

Hi VGama...you always take the time to provide great and current information...my urologist in CA said it was "advanced"...I'd shop for a new urologist but University of SF works with me plus I'm on a life long study with Northwestern by Dr. Catalona's team and they at some point in time (as you have noted)...my urologist in CA will be the last  to know...I'm  blessed for sure...i will bring up JH study  to my team...

I've taken on huge physical projects the last 7 years here in CA.  Its been good for me plus profitable too...sometimes I feel it keeps me alive...

 

Thxs

 

bdhilton
Posts: 776
Joined: Jan 2010

My PSA test on 01/27/2010 came back as 0.301 and they tell me I'm "stable", whatever that really means but I'll take it!

Steve1961
Posts: 301
Joined: Dec 2017

why do you say advanced ..looks like you had 5 years before reoccurance..did you have  a high gleason score or PSA just curious ..I am seeing someone at UCSF as well.dr Carroll ..

bdhilton
Posts: 776
Joined: Jan 2010

I've had surgery, salvage radiation and when it came back my doctors are referring to it as "Advanced cancer"...my original PSA score was 2.8...I stated this journey back in 2009...

VascodaGama's picture
VascodaGama
Posts: 3238
Joined: Nov 2010

Well, at least there were a decline of the values. This is a case for celebration.

bdhilton
Posts: 776
Joined: Jan 2010

Well...Jan 27, 2020 was 0.301 and my July 27th test came back at 0.60...it appears I've doubled in 6 months....;-(  I am video chatting with the doctor next Monday....

Clevelandguy
Posts: 592
Joined: Jun 2015

Hi bd,

You might want to talk to your doc the next time to see if genetic therapy might be another tool for you?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1476102/

Dave 3+4

bdhilton
Posts: 776
Joined: Jan 2010

Hi David,  thank you for your input and link...thxs

VascodaGama's picture
VascodaGama
Posts: 3238
Joined: Nov 2010

Hilton,

The doubling time should be calculated from the initial PSA 0.207 of March 2019. The increase to 0.60 represents a PSAdt of 8.7 months. Typically the threshold used to compare critical increases in cases like yours is a PSAdt of <9 months. You are close.

Your doctor may be waiting for a much higher level to start the new treatment which could be ADT (hormonal). In your meeting remember to inform him that you want to do a PET scan before starting something. This image exam will show you where the malignancy is located and the test should be done without the influence of any disrupting medication.

Let's hope for the best.

Regards

VG

bdhilton
Posts: 776
Joined: Jan 2010

Hi VG...yes, always hope for the best and second opinions...I always appreciate  your input and observations...Iooking forward with what the Dr has to say...The journey continues!  thank you

bdhilton
Posts: 776
Joined: Jan 2010

Hi VG....have you read this study?  Separately, I see my doubling time as 8.9-11.9 months?

 

Regards,

BD

bdhilton
Posts: 776
Joined: Jan 2010

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718717/

VascodaGama's picture
VascodaGama
Posts: 3238
Joined: Nov 2010

Hilton,

The study above is new to me but I have read similar studies done in the decade before 2010. I learn that a PSAdt of 9.5 months is the cutting threshold separating critical from benevolent progression.

My story with this threshold started when I consulted in 2001 Dr Susan Slovin (medical oncologist specialist in PCa) at MSKCC. She diagnosed my case as micrometastases and that made me curious. She formulated such diagnosis from the data pre and  post surgery, together with the information collected when the recurrence status was declared in March 2001, which presented extensive probabilities for far metastasis (therefore in urgent need of an earlier SRT), but that made Slovin to recommend me a wait and see (WW) period. Micrometastases cases were and still are considered to do badly in salvage radiotherapies (combination or multimodal treatments were inexistent at the time). Slovin was involved in studies regarding the optimal timing of salvage radiotherapy for biochemical recurrence after radical prostatectomy and was a supporter for early SRT but in her opinion this fact was controversial in some patients that presented micrometastases. Chemotherapy seemed to be better.

Mario Eisenberger from JH also had similar understanding and recommended me in 2002 to continue WW based on all previous exams and the PSAdt. I was asymptomatic and the data collected from sophisticated MRI annually put everything on hold. With no targets to aim the radiation would be like throwing arrows in the dark trying to hit the bandit. The PSAdt in the first year post RP was really short at 4.5 months. Then it flattens to a PSAdt of 11.1 months and at the end of my 6 years in WW it improved further to an envy PSAdt of 20.4 months.

Today I think that Slovin was right. My SRT was meticulously executed (high degree of confidence on the chosen covered field of attack and isodose planning) but recurrence was again experienced 4 years post SRT. The PSAdt at the time for starting ADT was at 9.9 months. Today 7 years OFF treatment (post two years of ADT) the PSA has increased and has shown two periods in plateaus but overall the PSAdt is calculated at 24.93 months. This seems good but it has no meaning in Systemic cases if a radical is no more an option. PSAdt would be important to you if you plan to go through oligometastatic treatment.

Thanks for the link.

Best wishes,

VGama

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