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Another bit of promising drugs news for recurrent/advanced

Tamlen's picture
Tamlen
Posts: 207
Joined: Jan 2018

It was a small study, but the results are pretty exciting: 30% response rate in recurrent/advanced disease, 49% in MSI-H tumors. Even better, the rates of adverse side effects were lower than other good-news research reported on recently. The drug is Dostarlimab, a checkpoint inhibitor. Here are the details:

Potential Game Changer for Endometrial Cancer

Acookie
Posts: 11
Joined: Aug 2018

Thanks, do you know if its for serous or endometroid cancer? I couldn't find reference to which type of cancer it was for

LisaPizza's picture
LisaPizza
Posts: 238
Joined: Feb 2018

The study itself doesn't specify, so I'd say they took all endometrial types, but the preliminary reporting didn't break down their particular results. 

Forherself's picture
Forherself
Posts: 240
Joined: Jan 2019

It looks like MSI is associated with Lynch syndrome and endometrioid endometrial cancer.   

Tamlen's picture
Tamlen
Posts: 207
Joined: Jan 2018

Yes, and MSS is not associated with Lynch, so the study may have included types beyond endometrioid adenocarcinoma.

63tattoolydia's picture
63tattoolydia
Posts: 2
Joined: Dec 2016

I am currently in a clinical trial using dostarlimab. I have recurrent endometrial cancer in my liver and both lungs. After going through all the chemo therapies available to me there was nothing else that could be done. Fortunately in Sept 2018, this immunotherapy drug was approved for trials. I am MSS (microsatellite stable). I can tell you this is amazing. I have such a great quality of life now. I am back in the gym and am now volunteering at my cancer center. The side effects for me have been nothing more than being alittle tired and the best way to combat that is exercising. I believe that immunotherapy can change cancer to a chronic disease that can be treated. I did not have quality of life with chemotherapy. I am so thankful to be in this trial.

Armywife's picture
Armywife
Posts: 325
Joined: Feb 2018

So happy that this is working for you!  Quality of life is important and the hope you give us is even more a blessing!  Thank you for sharing!

Denise66
Posts: 58
Joined: Aug 2018

I’m so happy for you!  What stage and grade were you?  

LisaPizza's picture
LisaPizza
Posts: 238
Joined: Feb 2018

Wow, so nice to hear that :) Glad you chimed in.

derMaus's picture
derMaus
Posts: 561
Joined: Nov 2016

Hello 63tattoolydia! I see this is your second post but you've been around much longer than that. Congratulations! Your story is very compelling; can I urge you to put some details under your About Me page so that others can benefit from your experience ? You can just cut and paste this posting if that's easier for you. I've been on Keytruda for a year now so anything new always catches my eye. Thanks again for the great post!

Jairoldi's picture
Jairoldi
Posts: 217
Joined: May 2017

Thanks for sharing and being an encouragement.

zsazsa1
Posts: 356
Joined: Oct 2018

Here's a link to a report on results from Phase I/II trials with dostarlimab.

https://www.drugdevelopment-technology.com/news/gsk-dostarlimab-endometrial-cancer-data/

ConnieSW's picture
ConnieSW
Posts: 1456
Joined: Jun 2012

delighted for you and nice to meet you. 

Forherself's picture
Forherself
Posts: 240
Joined: Jan 2019

I think they included MSI and MMS types.  That would be both endometrioid and serous.    This is a step forward.   It sounds very promising.

 

jjtrim's picture
jjtrim
Posts: 20
Joined: Mar 2019

Thanks for sharing your experience.  It's always nice to hear someone who is actually using these new therapies and exciting to hear they are working!  I'm hopeful.

63tattoolydia's picture
63tattoolydia
Posts: 2
Joined: Dec 2016

Ladies, yes immunotherapy is probably the most exciting new treatment that hopefully will soon be available for all of us endometrial cancer warriors. I am so blessed to have been selected for this trial. I have always told everyone that I am a warrior and my goal is not to be a survivor,  but the victor over cancer. We all will die someday, however I believe with immunotherapy we will live a better quality of live. I pray that someday chemotherapy and radiation will be things of the past. Love to you all.

 

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