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Mixed Response Taxol & Avastin

linmk's picture
linmk
Posts: 58
Joined: Sep 2017

 

I have been on Taxol and Avastin for the last three months. To refresh people's memories I am Stage IVB garden variety endometrial cancer. I have had three different chemo treatments, a hysterectomy, and two clinical trials, the last one was an immunotherapy trial. I won't be able to particpate in another immunotherapy trial because I am MSI-Stable and I didn't have a good response to the immunotherapy. The CT scan this past week showed that the newer places with tumors were responding to the Taxol and Avatin but the tumors in the older places like the lungs were growing. It's called a mixed response. So now I am on my sixth treatment plan, a regime of daily megace and tamoxifen tablets. No more infusions. Only the first chemo of Taxol and Carboplatin wiped out the tumors. I was NED for a brief period of less than three months.

I am supposed to return to MD Anderson in Houston at the end of three months for another CT scan. My left leg is still bothering me. It's because of the Taxol infusion that I had been taking. The pain should go away in a month now that I'm off the Taxol. I hope all is well with everyone.

 

 

Red Corvette
Posts: 104
Joined: Jan 2016

You are a strong brave warrior. Keep on fighting.

Red

Northwoodsgirl
Posts: 478
Joined: Oct 2009

Keeping you in my thoughts and prayers! I am sorry you are still having that leg pain.  You have gone through so much....((Hug))

Lori

paris11
Posts: 159
Joined: Oct 2010

I have stage 4B uterine cancer. The cancer was DX in 2007.  I have been in remission for four years.  The therapy is tamoxifen and megace.

Best, Connie 

derMaus's picture
derMaus
Posts: 476
Joined: Nov 2016

Paris, this is hugely comforting to know that someone with 4B in 2007 is around and in remission. Thank you for your post, and may I beg you to please put that information on your "About me" page so others can see it? It's immensely comforting.

paris11
Posts: 159
Joined: Oct 2010

Will do derMaus.  Briefly I was Dx stage 4 B. In 2007.  I was 69 years.  I was told I had less than a year.  I seriously considered swimming into the Atlantic Ocean.  Today I am 81 and just returned from an easy swim.  The tamoxifen and megace turned the tide.  My oncologist thinks Its a cure.

LadyMox's picture
LadyMox
Posts: 56
Joined: Sep 2018

That is wonderful to hear!

cmb's picture
cmb
Posts: 247
Joined: Jan 2018

Paris11,

Thank you so much for checking in and sharing your good news. Women, especially those struggling with late stage cancer, really appreciate hearing about cases like yours. Here's to many more years of wonderful ocean swims.

LadyMox's picture
LadyMox
Posts: 56
Joined: Sep 2018

Good to hear you had some response, but sorry to hear not all your tumors responded. I hope they can find something that works for the other tumors.

NoTimeForCancer's picture
NoTimeForCancer
Posts: 2416
Joined: Mar 2013

linmk, I have been thinking of you.  Thank you for checking in.  Hugs dear one.

LisaPizza's picture
LisaPizza
Posts: 149
Joined: Feb 2018

I'm glad to hear from you! I hope the experimentation pays off this time, and hope for the day none of us have to be experimented on.

Wannabeatit
Posts: 86
Joined: Dec 2017

Hope it works for you. Looks like Paris 11 has had some good results with the same treatment?

 

EZLiving66's picture
EZLiving66
Posts: 1249
Joined: Oct 2015

I was wondering how you were doing. I sure hope this new regiment works for you! 

Love, 

Eldri 

derMaus's picture
derMaus
Posts: 476
Joined: Nov 2016

Linmk, I'm so glad to hear from you! I wish all the tumors were shrinking but at least some of them are, which beats the alternative. Has glutamine been of any help to you with the Taxol side effects? You're in my thoughts and prayers. B

Armywife's picture
Armywife
Posts: 158
Joined: Feb 2018

Thank you so much for updating us.  I think of you so often since we ran into each other at MD Anderson!  Praying now that the pain in your leg subsides quickly, and that you have wonderful results with the new protocol.  As a fellow Stage IVB garden variety, I am so encouraged by Paris's comment that the same treatment turned the tide for her!  Please keep us posted, friend!

pato58's picture
pato58
Posts: 97
Joined: Jun 2018

Keeping you in my thoughts too!
Have a good weekend Smile

hopeful56's picture
hopeful56
Posts: 73
Joined: Jul 2017

Linmk,

You are in my thoughts and prayers.  I hope your pain is alleviated and all the tumors shrink.

Sending you hugs.

paris11
Posts: 159
Joined: Oct 2010

Dr. Coleman at MDA and Dr. Brian Slomovitz at Sylvester Cancer in Miami are doing cutting edge research into recurrent EC.

linmk's picture
linmk
Posts: 58
Joined: Sep 2017

Paris11, I'm glad to hear that you're doing so well. Many more enjoyable swims. I have two questions: How many different types of treatment did you endure before your oncologist put you on megace and tamoxifen? Were you presented with other choices besides those?

derMaus, the glutamine does work when I remember to take it. At least it seems to lessen the amount of pain medicine I take. Lately, I've been fighting fatigue, perhaps because of the megace. I seem to need more sleep lately.

I hope everyone is doing well. Again thank you for your support.

MAbound
Posts: 646
Joined: Jun 2016

I felt tired a lot on Megace, too, so that is definetly a side effect. I slept so soundly on it without dreaming. Since I've stopped the Megace a couple of weeks ago I'm back to having a very active mind when I sleep and now I am tired because I'm not getting a good night's sleep. I kind of miss the dreamless sleeping.

SF73
Posts: 207
Joined: Oct 2017

So glad to read about Paris's story. I hope that tamoxifen and megace would be the answer for you as well, linmk. Sorry about your fatigue. Hope it gets better. Keeping you in my thoughts. 

paris11
Posts: 159
Joined: Oct 2010

I have had problems resetting my password.

Long and winding road:

2007. DX with EC Stage 1:  I had sub optimal debunking surgery at Northwestern.  Chemo was not offered.

 

2008:  Mets to liver, abdomen and lymph nodes.  TX was Carbo/Taxol.  18 month remission.

2010: surgery to remove lymph nodes and resection diaphragm.  TX was 6 rounds IP/IV Carbo/Taxol.  31 month remission.

2013:  Splenectomy and removal of lymph nodes. 6 weeks of radiation to lymph nodes. TX Carbo/Taxol 18 month remission.

2014:  Tumor growing like a vine around aorta.  I enrolled in hospice.  I requested Tamoxifin/Megace.

2015:  CT scan showed NED.  43 month remission.

i am humbled.  I live with gratitude.  I will try to keep up with conversation.

Connie

LisaPizza's picture
LisaPizza
Posts: 149
Joined: Feb 2018

Thank you so much for sharing, so encouraging. 

derMaus's picture
derMaus
Posts: 476
Joined: Nov 2016

Connie, this is great; it's beyond encouraging! Might I beg you to cut and paste the info onto your About Me page? I'm sorry to be a pest, I'm bugging everyone to do this. Laughing Your story is a wonderful one, thank you again for sharing it. Best always, B

Armywife's picture
Armywife
Posts: 158
Joined: Feb 2018

You are a WARRIOR PRINCESS.  I'm in awe.

SF73
Posts: 207
Joined: Oct 2017

What a journey! I am also in awe. Thank you so much for sharing. May I ask if you are still on Megace?

paris11
Posts: 159
Joined: Oct 2010

I had tumor testing in 2010 and again in 2014.  Both tests showed Carbo/Taxol recommendation and 98% estroge positive.  I also had an extremely aggressive oncologis.  If CT scan showed a growth, doc would remove it.

NoTimeForCancer's picture
NoTimeForCancer
Posts: 2416
Joined: Mar 2013

Thank you, Connie.  We all need to hear these things.  I would agree with B that everyone take a moment to update their "about me" page.  I think we tend to set it up when we first join, but I have clicked on people's names hoping to learn more about what they did for treatments, etc.  Some people just stop coming here and stories like this are important for people to see. 

linmk's picture
linmk
Posts: 58
Joined: Sep 2017

Connie, You have been through a lot. I see that you've had a lot of carbo/taxol treatments and episodes of NED in between. Carbo/Taxol initially worked well for me for maybe one or two months,  but I only had that combination the first time. This last time it was Carbo/Avastin--mixed results. I don't think that I was tested to see what would work best for my tumors. It was standard Carbo/Taxol, then after that, whatever the Tumor Board recommended. I don't think the Tumor Board recommended the megace/taxmoxifen treatment. The gyneconologist oncologist just told me that that was what I was going to get, given the fact that I wasn't NED but I still wasn't ready for hospice. Good Health to you. Glad to hear from you.

paris11
Posts: 159
Joined: Oct 2010

The oncologist pushed hard for another TX of Carbo/Taxol.  I had a long recovery after the previous Regime of Carbo/Taxol and I said NO MORE.   The oncologist Reluctantly agreed to try Tamoxifen/Megace.  Now, he twirls around the exam room when he sees me. He seems to think the Tamoxifen/Megace was his recommendation.  I say nothing.

paris11
Posts: 159
Joined: Oct 2010

Yes, I take Megace for three weeks then I take Tamoxifen for three weeks.  It is my understanding that the Megace strengths the activity of the Tamoxifen.  I also take Eliquis to prevent blood clots.

I am having trouble cutting and pasting.  But I will work on it.

Connie

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