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POLE ultra-mutated endometrial cancer and immunotherapy

SF73
Posts: 276
Joined: Oct 2017

This is the third time I am trying to post this message. It seems if I add a hyperlink the post is deleted.  

In addition to tumours that have Micro Satellite Instability, it seems tumours that have the POLE exonuclease domain mutations are also good candidates for immunotherapy. If the genomic profiling of your tumour indicated the POLE mutation and you are experiencing a recurrence please check with your doctor to see if immunotherapy could be an option for you.

Here are a few papers that you might find interesting:

On tumor mutational burden and its ability predict response to immunotherapy

https://www.foundationmedicine.com/blog/new-data-suggest-tumor-mutational-burden-could-help-predict-response-to

 

Tumor genotype and immune microenvironment in POLE-ultramutated and MSI-hypermutated Endometrial Cancers: New candidates for checkpoint blockade immunotherapy?

https://www.ncbi.nlm.nih.gov/pubmed/27362548

 

Polymerase proofreading domain mutations: New opportunities for immunotherapy in hypermutated colorectal cancer beyond MMR deficiency.

https://www.ncbi.nlm.nih.gov/pubmed/28427513

 

Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine

https://www.sciencedirect.com/science/article/pii/S0959804917311462

 

 

Northwoodsgirl
Posts: 536
Joined: Oct 2009

Thano you so much for posting this information. It is challenging to stay on top

 of this!

Lori

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