The Cancer Survivors Network (CSN) is a peer support community for cancer patients, survivors, caregivers, families, and friends! CSN is a safe place to connect with others who share your interests and experiences.

Thank you for being a part of the Cancer Survivor Network community. Survivors and caregivers like you have played a unique role in fostering an online environment that encourages connection among those needing support, community, and education. On May 28, the Network will be discontinued. More details are available here . If you have any questions, contact CSNSupportTeam@cancer.org. Thanks again for the support you’ve provided each other over the years. We remain committed to supporting you in other ways throughout your cancer journey.

POLE ultra-mutated endometrial cancer and immunotherapy

SF73
SF73 CSN Member Posts: 317 Member
edited March 2018 in Uterine/Endometrial Cancer #1

This is the third time I am trying to post this message. It seems if I add a hyperlink the post is deleted.  

In addition to tumours that have Micro Satellite Instability, it seems tumours that have the POLE exonuclease domain mutations are also good candidates for immunotherapy. If the genomic profiling of your tumour indicated the POLE mutation and you are experiencing a recurrence please check with your doctor to see if immunotherapy could be an option for you.

Here are a few papers that you might find interesting:

On tumor mutational burden and its ability predict response to immunotherapy

https://www.foundationmedicine.com/blog/new-data-suggest-tumor-mutational-burden-could-help-predict-response-to

 

Tumor genotype and immune microenvironment in POLE-ultramutated and MSI-hypermutated Endometrial Cancers: New candidates for checkpoint blockade immunotherapy?

https://www.ncbi.nlm.nih.gov/pubmed/27362548

 

Polymerase proofreading domain mutations: New opportunities for immunotherapy in hypermutated colorectal cancer beyond MMR deficiency.

https://www.ncbi.nlm.nih.gov/pubmed/28427513

 

Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine

https://www.sciencedirect.com/science/article/pii/S0959804917311462

 

 

Like Care

Comments

  • Northwoodsgirl
    Northwoodsgirl CSN Member Posts: 572 Member
    #2
    Genetic testing

    Thano you so much for posting this information. It is challenging to stay on top

     of this!

    Lori

    Like Care

Discussion Boards