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Differences in type of Uterine cancers

namedropper
Posts: 97
Joined: Dec 2014

What are the differences between what I have MMMT uterine cancer and the other type of uterine cancers?  I read all of the posts but don.t post much. Thanks

EZLiving66's picture
EZLiving66
Posts: 1040
Joined: Oct 2015

There are a couple of ladies on this site who are experts on the differences in uterine cancer.  I'm sure they'll be along shortly and can explain it.

Love,

Eldri

Abbycat2's picture
Abbycat2
Posts: 572
Joined: Feb 2014

Maybe this will be helpful-

 
Endometrial cancer begins in the inner layer or endometrium. For the most part uterine sarcomas develop in the myometrium, or uterine muscle wall.  

Both are correctly referred to as uterine cancer, because both develop in the uterus. However, the cancer that starts in the endometrium of the uterus is commonly referred to as endometrial cancer to distinguish this type of cancer from uterine sarcoma. Most uterine cancer (approximately 95%) is endometrial cancer.
namedropper
Posts: 97
Joined: Dec 2014

When they do a roll call on the board I don't know where to go.  The Dr. said I have carcinosarcoma which is also called MMMT i think.  From what I know it is a mix of 2 kinds.  Some of the women have UPSC and others have other kinds. I think I have serous adencarcinoma.    I will will check with my Dr.    thanks    all of you are so kind. 

NoTimeForCancer's picture
NoTimeForCancer
Posts: 1907
Joined: Mar 2013

(Google sez)

As its name implies, this is a biphasic (two-component) tumor which contains an admixture of carcinoma (cancer showing epithelial differentiation) and sarcoma (cancer showing mesenchymal differentiation) components. In the great majority of uterine carcinosarcoma, both the carcinoma and the sarcoma components are histologically high-grade. 

namedropper
Posts: 97
Joined: Dec 2014

Do they sometimes have a roll call for MMMT uterine cancer?   thanks

NoTimeForCancer's picture
NoTimeForCancer
Posts: 1907
Joined: Mar 2013

namedropper, we do have some women here who have MMMT.  Some post regularly, some check in, and some do not comehere much anymore.  Percentage-wise it is a small group in respect to all of uterine cancers, but because this is specifically a cancer chat board they do come here.  You can start a thread for that if you would like.  I know it helps to know you are not alone in your fight, and why I have always like the inclusive roll call.  UPSC, MMMT, a few others, are rare and I like to think we need to look to how they are treating ovarian cancer to make progress on our since it has similar traits. 

BC Brady's picture
BC Brady
Posts: 70
Joined: May 2015

Thank you all for covering this. My initial dx was stage 4 adenocarcinoma metastatic. I was told that it is the middle of three types, and rare, at only 10% of uterine cancers. At some point UPSC has been on my info sheets - so I'm really not sure if what I have is the same as what I started with or has turned into UPSC? Apparently I am not an actual medical person and just play one with my friends who think I know everything!

Billie

TeddyandBears_Mom's picture
TeddyandBears_Mom
Posts: 1301
Joined: Jun 2015

I think most of our MMMT ladies post on the other uterine type - UPSC since they seem to be treated the same way.

There may have been a MMMT thread several years ago if you have the time to search for it.

I haven't seen a roll call specific to it since I joined.

Are you looking for specific information?

Love and Hugs,

Cindi

Editgrl's picture
Editgrl
Posts: 901
Joined: Jun 2015

originally with the pathologist describing the tumor as primarily high-grade carcinomatous compenent and scant sarcomatous component.  However, a second pathologist did not think there was enough evidence of a sarcomatous element to confirm carcinosarcoma and re-classified it as a high-grade serous carcinoma.  Pathologists can disagree.  Carcinosarcoma makes up something like 1-5% of all uterine cancers, so there are not a lot of women on this board with that diagnosis.  TXTrisha55, Nempark, Giggs100 off the top of my head, are a few of the women who post here diagnosed with MMMT.

Chris

DrienneB's picture
DrienneB
Posts: 182
Joined: Aug 2013

Yes, sometimes people with MMMT or carcinosarcoma are asked to check in. My info. below (using Kim's template!):

Debulking Surgery (TAH & BSO, 84 lymph nodes excised) - May 2013; 51 years old
Dx: Uterine MMMT Stage 3b, Grade 3 - May 2013
Chemo: (Taxol + Carboplatin) - 6 rounds - June -Sept. 2013

No Radiation

There are several who contribute to this discussion board who have survived and thrived well beyond the poor prognosis that the non-current statistics for this diagnosis seem to suggest.

Best to you, and to all of the dear women who give their time and hearts to this board.

-j

SandyD's picture
SandyD
Posts: 123
Joined: Oct 2015

For me, I had both carcinosarcoma (MMMT) and papillary serous (UPSC).

Kvdyson's picture
Kvdyson
Posts: 789
Joined: Jan 2016

Hi namedropper, I am fighting stage 1b, grade 3 MMMT uterine cancer. The biggest difference that I can tell between it and the other types is that the treatment tends to be more aggressive (since it is an aggressive form). For instance, eventhough mine was caught at an early stage, the treatment is along the lines of what a stage 3 "regular" uterine cancer might receive. I hope this helps!

Wishing you strength and good health,
Kim
Debulking Surgery 10.5 cm (TAH & BSO, 14 lymph nodes excised) - Sept 2015; 47 years old
Dx: Uterine MMMT Stage 1b, Grade 3 - Sept 2015
Frontline: Chemo (Taxol-day 1 & Ifosfamide/Mesna-days 1-3) - 6 rounds - Dec 2015 - June 2016
Radiation - external, 28 treatments over 6 weeks - Feb - Mar 2016

 

namedropper
Posts: 97
Joined: Dec 2014

Thanks. I know it is rare. I also had lobular breast cancer in June 2012 and MMMT June 2014. I guess I am a rare bird. I feel pretty good so far. I am 74 years old and have RA and much more but I am a real fighter. I have been Ned starting Oct. 2014     The women on this board are sooooo great.

Gardena
Posts: 98
Joined: Jan 2016

I just read your post and saw you're getting chemo and radiation concurrently.  How is it going,  you holding up alright? I remember reading you were getting imrt - have you started and are you experiencing any side effects?  I hope all is going well for you.

 

Kvdyson's picture
Kvdyson
Posts: 789
Joined: Jan 2016

Hi Gardena, my chemo and radiation treatments are sandwiched (3 rounds of chemo / 6 weeks of radiation / 3 rounds of chemo). I have one week of radiation left then will have a glorious 4 weeks with no treatments before starting the last 3 rounds of chemo.

So far I've experienced very few side effects from the radiation (external - photon - 3D conformal) - just a few instances of diarrhea that have been easy to manage with OTC Immodium AD. I think that the advice that I read on this forum about taking probiotics during the treatments have really helped so thank you to everyone for that!

The daily treatments are painless and take about 5 minutes. I get them on my way into my full-time job. Overall, I'm doing very well and trying to stay busy living. How are you doing?

 

EZLiving66's picture
EZLiving66
Posts: 1040
Joined: Oct 2015

Kim, I'm so glad you're doing so good.  The PA of my oncologist told me the internal radiation was the easiest part - as if anything is easy in this.  My doctor didn't recommend any radiation since I was Stage II but that may change as time goes on.

Have a good weekend!

Love,

Eldri

Kvdyson's picture
Kvdyson
Posts: 789
Joined: Jan 2016

Thanks, Eldri! I hope you have a good weekend, too!

Soup52's picture
Soup52
Posts: 660
Joined: Jan 2016

I have clear cell endometrial cancer. Does anyone else on this board have this kind?

alwayslookup
Posts: 1
Joined: Aug 2016

I am new to this site.  I was diagnosed with MMMT 1B and had a total hysterectomy in October 2011.  Had Carbo/Taxol for 6 rounds, split by radiation for 25 days then hi-dose radiation to top of vagina, completing in June of 2012.  18 months remission with recurrence in Jan of 2014.  8 rounds of carbo/taxol, resulting in NED. Completed in October 2014.  Some were extended due to low platelet counts.  Tumor was again measurable by January 2015, when I went on a clinical trial.  Finished that in August 2015 due to bad side effects and waning effectiveness.  Started another clinical trial in September 2015 involving taxol and another drug which I am still on, but may not be for much longer as it seems to be losing its effectiveness.  It will be 5 years in 2 months, and although it had started to spread to 3 lymph nodes, they are now clear and my tumor is contained.

First and foremost, I have found that attitude plays a HUGE role in handling all this.  I realize that there may not be a miracle cure, but eating well, exercising, and smiling a lot works wonders.  I also look at this as an adventure.  As one path closes, I look toward the next, hoping for the best.  I have worked with absolutely wonderful doctors and nurses, totally dedicated to curing cancer and treating their patients.

After all that, my question is:  aside from carbo/taxol (or anything with taxol as I may now be resistant to it), what treatments have MMMT patients found to be the most helpful and what are the side effects?  I have had few side effects other than on the one clinical trial, and - thank goodness - no nausea.  Just trying to do some research and thinking early.

Thanks.  And I think this site is great!  Wish I had found it before!

Diana7755
Posts: 7
Joined: Aug 2016

I had the Carbo/taxol. Had to switch to taxotere because of neuropathy. 6 cycles. Took a break and 4 months later the cancer grew back. I have just started Cisplatin. The first treatment did make me feel nauseous even on the anti nausea meds. Not looking forward to the next treatment. 

Kvdyson's picture
Kvdyson
Posts: 789
Joined: Jan 2016

Alwayslookup, I was diagnosed with stage 1b, grade 3, uterine MMMT in September 2015. Surgery was TAH & BSO, 14 lymph nodes excised, 10.5 cm tumor removed. My treatment was 6 rounds of chemo ( Ifex/Mesna/Taxol) with 28 external radiation treatments "sandwiched" between the 3rd and 4th rounds of chemo. I finished treatment at the end of May 2016 and have been NED since June 2016. Side effects of treatment were minimal and easily managed. My gyn-onc had sent a piece of the tumor out for testing with various chemo meds and the Ifex/Taxol combo was most effective in the petri dish so that is why he went that route with me. The test is called ChemoFx by a company called Helomics. Hope this information helps you. Kim

ConnieSW's picture
ConnieSW
Posts: 1193
Joined: Jun 2012

I didn't have MMMT and am lucky that I haven't had a recurrence but I just wanted to say hi and welcome you.  You have a wonderful positive  attitude.  I wish you the best and keep coming here.

Editgrl's picture
Editgrl
Posts: 901
Joined: Jun 2015

 or MMMT Stage 3C2, June of last year.  The only treatments I have had so far are six rounds of carbo/taxol and HDR brachytherapy, so I can't offer any first hand experience of other chemo.  Treatments ended in February of this year and so far I am NED.  I have heard of ilfosfamide and mesna being used in addition to carbo for this particular cancer.  

I am working with a naturopathic oncologist in addition to my "traditional" oncology team, and I am currently on low dose naltrexone and mistletoe extract injections as well as a handful of supplements to help keep my immune system strong and to hopefully prevent recurrence. Neither the LDN nor the mistletoe has had any significant side effects.

I am totally in agreement with you on attitude.  It may not be a cure, but it sure helps in dealing with the uncertainty of having a high grade cancer and all that goes with that.  Exercise, a sensible diet, and spending as much time as possible doing the things that bring joy have helped immensely.

Welcome to the board!

Chris

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