Differences in type of Uterine cancers

namedropper · February 2016

What are the differences between what I have MMMT uterine cancer and the other type of uterine cancers? I read all of the posts but don.t post much. Thanks

EZLiving66 · February 2016

There are a couple of ladies

There are a couple of ladies on this site who are experts on the differences in uterine cancer. I'm sure they'll be along shortly and can explain it.

Love,

Eldri

Abbycat2 · February 2016

Maybe this will be

Maybe this will be helpful-

Endometrial cancer begins in the inner layer or endometrium. For the most part uterine sarcomas develop in the myometrium, or uterine muscle wall.

Both are correctly referred to as uterine cancer, because both develop in the uterus. However, the cancer that starts in the endometrium of the uterus is commonly referred to as endometrial cancer to distinguish this type of cancer from uterine sarcoma. Most uterine cancer (approximately 95%) is endometrial cancer.

namedropper · February 2016

Abbycat2 said:
Maybe this will be
Maybe this will be helpful-

Endometrial cancer begins in the inner layer or endometrium. For the most part uterine sarcomas develop in the myometrium, or uterine muscle wall.

Both are correctly referred to as uterine cancer, because both develop in the uterus. However, the cancer that starts in the endometrium of the uterus is commonly referred to as endometrial cancer to distinguish this type of cancer from uterine sarcoma. Most uterine cancer (approximately 95%) is endometrial cancer.

Difference

When they do a roll call on the board I don't know where to go. The Dr. said I have carcinosarcoma which is also called MMMT i think. From what I know it is a mix of 2 kinds. Some of the women have UPSC and others have other kinds. I think I have serous adencarcinoma. I will will check with my Dr. thanks all of you are so kind.

NoTimeForCancer · February 2016

namedropper said:
Difference
When they do a roll call on the board I don't know where to go. The Dr. said I have carcinosarcoma which is also called MMMT i think. From what I know it is a mix of 2 kinds. Some of the women have UPSC and others have other kinds. I think I have serous adencarcinoma. I will will check with my Dr. thanks all of you are so kind.

malignant mixed Mullerian tumor, MMMT

(Google sez)

As its name implies, this is a biphasic (two-component) tumor which contains an admixture of carcinoma (cancer showing epithelial differentiation) and sarcoma (cancer showing mesenchymal differentiation) components. In the great majority of uterine carcinosarcoma, both the carcinoma and the sarcoma components are histologically high-grade.

namedropper · February 2016

NoTimeForCancer said:
malignant mixed Mullerian tumor, MMMT
(Google sez)

As its name implies, this is a biphasic (two-component) tumor which contains an admixture of carcinoma (cancer showing epithelial differentiation) and sarcoma (cancer showing mesenchymal differentiation) components. In the great majority of uterine carcinosarcoma, both the carcinoma and the sarcoma components are histologically high-grade.

Difference

Do they sometimes have a roll call for MMMT uterine cancer? thanks

NoTimeForCancer · February 2016

namedropper said:
Difference
Do they sometimes have a roll call for MMMT uterine cancer? thanks

namedropper, we do have some

namedropper, we do have some women here who have MMMT. Some post regularly, some check in, and some do not comehere much anymore. Percentage-wise it is a small group in respect to all of uterine cancers, but because this is specifically a cancer chat board they do come here. You can start a thread for that if you would like. I know it helps to know you are not alone in your fight, and why I have always like the inclusive roll call. UPSC, MMMT, a few others, are rare and I like to think we need to look to how they are treating ovarian cancer to make progress on our since it has similar traits.

TeddyandBears_Mom · February 2016

namedropper said:
Difference
Do they sometimes have a roll call for MMMT uterine cancer? thanks

I think most of our MMMT

I think most of our MMMT ladies post on the other uterine type - UPSC since they seem to be treated the same way.

There may have been a MMMT thread several years ago if you have the time to search for it.

I haven't seen a roll call specific to it since I joined.

Are you looking for specific information?

Love and Hugs,

Cindi

Editgrl · February 2016

namedropper said:
Difference
Do they sometimes have a roll call for MMMT uterine cancer? thanks

I was diagnosed with carcinosarcoma

originally with the pathologist describing the tumor as primarily high-grade carcinomatous compenent and scant sarcomatous component. However, a second pathologist did not think there was enough evidence of a sarcomatous element to confirm carcinosarcoma and re-classified it as a high-grade serous carcinoma. Pathologists can disagree. Carcinosarcoma makes up something like 1-5% of all uterine cancers, so there are not a lot of women on this board with that diagnosis. TXTrisha55, Nempark, Giggs100 off the top of my head, are a few of the women who post here diagnosed with MMMT.

Chris

Kvdyson · February 2016

MMMT Uterine Cancer

Hi namedropper, I am fighting stage 1b, grade 3 MMMT uterine cancer. The biggest difference that I can tell between it and the other types is that the treatment tends to be more aggressive (since it is an aggressive form). For instance, eventhough mine was caught at an early stage, the treatment is along the lines of what a stage 3 "regular" uterine cancer might receive. I hope this helps!

Wishing you strength and good health,
Kim
Debulking Surgery 10.5 cm (TAH & BSO, 14 lymph nodes excised) - Sept 2015; 47 years old
Dx: Uterine MMMT Stage 1b, Grade 3 - Sept 2015
Frontline: Chemo (Taxol-day 1 & Ifosfamide/Mesna-days 1-3) - 6 rounds - Dec 2015 - June 2016
Radiation - external, 28 treatments over 6 weeks - Feb - Mar 2016

DrienneB · February 2016

namedropper said:
Difference
Do they sometimes have a roll call for MMMT uterine cancer? thanks

MMMT Roll Call

Yes, sometimes people with MMMT or carcinosarcoma are asked to check in. My info. below (using Kim's template!):

Debulking Surgery (TAH & BSO, 84 lymph nodes excised) - May 2013; 51 years old
Dx: Uterine MMMT Stage 3b, Grade 3 - May 2013
Chemo: (Taxol + Carboplatin) - 6 rounds - June -Sept. 2013

No Radiation

There are several who contribute to this discussion board who have survived and thrived well beyond the poor prognosis that the non-current statistics for this diagnosis seem to suggest.

Best to you, and to all of the dear women who give their time and hearts to this board.

-j

namedropper · February 2016

Kvdyson said:
MMMT Uterine Cancer
Hi namedropper, I am fighting stage 1b, grade 3 MMMT uterine cancer. The biggest difference that I can tell between it and the other types is that the treatment tends to be more aggressive (since it is an aggressive form). For instance, eventhough mine was caught at an early stage, the treatment is along the lines of what a stage 3 "regular" uterine cancer might receive. I hope this helps!

Wishing you strength and good health,
Kim
Debulking Surgery 10.5 cm (TAH & BSO, 14 lymph nodes excised) - Sept 2015; 47 years old
Dx: Uterine MMMT Stage 1b, Grade 3 - Sept 2015
Frontline: Chemo (Taxol-day 1 & Ifosfamide/Mesna-days 1-3) - 6 rounds - Dec 2015 - June 2016
Radiation - external, 28 treatments over 6 weeks - Feb - Mar 2016

Differences

Thanks. I know it is rare. I also had lobular breast cancer in June 2012 and MMMT June 2014. I guess I am a rare bird. I feel pretty good so far. I am 74 years old and have RA and much more but I am a real fighter. I have been Ned starting Oct. 2014 The women on this board are sooooo great.

Soup52 · March 2016

I have clear cell endometrial

I have clear cell endometrial cancer. Does anyone else on this board have this kind?

Gardena · March 2016

Kvdyson said:
MMMT Uterine Cancer
Hi namedropper, I am fighting stage 1b, grade 3 MMMT uterine cancer. The biggest difference that I can tell between it and the other types is that the treatment tends to be more aggressive (since it is an aggressive form). For instance, eventhough mine was caught at an early stage, the treatment is along the lines of what a stage 3 "regular" uterine cancer might receive. I hope this helps!

Wishing you strength and good health,
Kim
Debulking Surgery 10.5 cm (TAH & BSO, 14 lymph nodes excised) - Sept 2015; 47 years old
Dx: Uterine MMMT Stage 1b, Grade 3 - Sept 2015
Frontline: Chemo (Taxol-day 1 & Ifosfamide/Mesna-days 1-3) - 6 rounds - Dec 2015 - June 2016
Radiation - external, 28 treatments over 6 weeks - Feb - Mar 2016

Kim

I just read your post and saw you're getting chemo and radiation concurrently. How is it going, you holding up alright? I remember reading you were getting imrt - have you started and are you experiencing any side effects? I hope all is going well for you.

Kvdyson · March 2016

Gardena said:
Kim
I just read your post and saw you're getting chemo and radiation concurrently. How is it going, you holding up alright? I remember reading you were getting imrt - have you started and are you experiencing any side effects? I hope all is going well for you.

Radiation Over Next Week

Hi Gardena, my chemo and radiation treatments are sandwiched (3 rounds of chemo / 6 weeks of radiation / 3 rounds of chemo). I have one week of radiation left then will have a glorious 4 weeks with no treatments before starting the last 3 rounds of chemo.

So far I've experienced very few side effects from the radiation (external - photon - 3D conformal) - just a few instances of diarrhea that have been easy to manage with OTC Immodium AD. I think that the advice that I read on this forum about taking probiotics during the treatments have really helped so thank you to everyone for that!

The daily treatments are painless and take about 5 minutes. I get them on my way into my full-time job. Overall, I'm doing very well and trying to stay busy living. How are you doing?

EZLiving66 · March 2016

Kvdyson said:
Radiation Over Next Week
Hi Gardena, my chemo and radiation treatments are sandwiched (3 rounds of chemo / 6 weeks of radiation / 3 rounds of chemo). I have one week of radiation left then will have a glorious 4 weeks with no treatments before starting the last 3 rounds of chemo.

So far I've experienced very few side effects from the radiation (external - photon - 3D conformal) - just a few instances of diarrhea that have been easy to manage with OTC Immodium AD. I think that the advice that I read on this forum about taking probiotics during the treatments have really helped so thank you to everyone for that!

The daily treatments are painless and take about 5 minutes. I get them on my way into my full-time job. Overall, I'm doing very well and trying to stay busy living. How are you doing?

Kim, I'm so glad you're doing

Kim, I'm so glad you're doing so good. The PA of my oncologist told me the internal radiation was the easiest part - as if anything is easy in this. My doctor didn't recommend any radiation since I was Stage II but that may change as time goes on.

Have a good weekend!

Love,

Eldri

Kvdyson · March 2016

EZLiving66 said:
Kim, I'm so glad you're doing
Kim, I'm so glad you're doing so good. The PA of my oncologist told me the internal radiation was the easiest part - as if anything is easy in this. My doctor didn't recommend any radiation since I was Stage II but that may change as time goes on.

Have a good weekend!

Love,

Eldri

Hope you have a good weekend too!

Thanks, Eldri! I hope you have a good weekend, too!

alwayslookup · August 2016

MMMT Treat

I am new to this site. I was diagnosed with MMMT 1B and had a total hysterectomy in October 2011. Had Carbo/Taxol for 6 rounds, split by radiation for 25 days then hi-dose radiation to top of vagina, completing in June of 2012. 18 months remission with recurrence in Jan of 2014. 8 rounds of carbo/taxol, resulting in NED. Completed in October 2014. Some were extended due to low platelet counts. Tumor was again measurable by January 2015, when I went on a clinical trial. Finished that in August 2015 due to bad side effects and waning effectiveness. Started another clinical trial in September 2015 involving taxol and another drug which I am still on, but may not be for much longer as it seems to be losing its effectiveness. It will be 5 years in 2 months, and although it had started to spread to 3 lymph nodes, they are now clear and my tumor is contained.

First and foremost, I have found that attitude plays a HUGE role in handling all this. I realize that there may not be a miracle cure, but eating well, exercising, and smiling a lot works wonders. I also look at this as an adventure. As one path closes, I look toward the next, hoping for the best. I have worked with absolutely wonderful doctors and nurses, totally dedicated to curing cancer and treating their patients.

After all that, my question is: aside from carbo/taxol (or anything with taxol as I may now be resistant to it), what treatments have MMMT patients found to be the most helpful and what are the side effects? I have had few side effects other than on the one clinical trial, and - thank goodness - no nausea. Just trying to do some research and thinking early.

Thanks. And I think this site is great! Wish I had found it before!

ConnieSW · August 2016

I wish you'd found it before, too

I didn't have MMMT and am lucky that I haven't had a recurrence but I just wanted to say hi and welcome you. You have a wonderful positive attitude. I wish you the best and keep coming here.

Editgrl · August 2016

I was diagnosed with carcinosarcoma

or MMMT Stage 3C2, June of last year. The only treatments I have had so far are six rounds of carbo/taxol and HDR brachytherapy, so I can't offer any first hand experience of other chemo. Treatments ended in February of this year and so far I am NED. I have heard of ilfosfamide and mesna being used in addition to carbo for this particular cancer.

I am working with a naturopathic oncologist in addition to my "traditional" oncology team, and I am currently on low dose naltrexone and mistletoe extract injections as well as a handful of supplements to help keep my immune system strong and to hopefully prevent recurrence. Neither the LDN nor the mistletoe has had any significant side effects.

I am totally in agreement with you on attitude. It may not be a cure, but it sure helps in dealing with the uncertainty of having a high grade cancer and all that goes with that. Exercise, a sensible diet, and spending as much time as possible doing the things that bring joy have helped immensely.

Welcome to the board!

Chris

Diana7755 · August 2016

alwayslookup said:
MMMT Treat
I am new to this site. I was diagnosed with MMMT 1B and had a total hysterectomy in October 2011. Had Carbo/Taxol for 6 rounds, split by radiation for 25 days then hi-dose radiation to top of vagina, completing in June of 2012. 18 months remission with recurrence in Jan of 2014. 8 rounds of carbo/taxol, resulting in NED. Completed in October 2014. Some were extended due to low platelet counts. Tumor was again measurable by January 2015, when I went on a clinical trial. Finished that in August 2015 due to bad side effects and waning effectiveness. Started another clinical trial in September 2015 involving taxol and another drug which I am still on, but may not be for much longer as it seems to be losing its effectiveness. It will be 5 years in 2 months, and although it had started to spread to 3 lymph nodes, they are now clear and my tumor is contained.

First and foremost, I have found that attitude plays a HUGE role in handling all this. I realize that there may not be a miracle cure, but eating well, exercising, and smiling a lot works wonders. I also look at this as an adventure. As one path closes, I look toward the next, hoping for the best. I have worked with absolutely wonderful doctors and nurses, totally dedicated to curing cancer and treating their patients.

After all that, my question is: aside from carbo/taxol (or anything with taxol as I may now be resistant to it), what treatments have MMMT patients found to be the most helpful and what are the side effects? I have had few side effects other than on the one clinical trial, and - thank goodness - no nausea. Just trying to do some research and thinking early.

Thanks. And I think this site is great! Wish I had found it before!

I had the Carbo/taxol. Had to

I had the Carbo/taxol. Had to switch to taxotere because of neuropathy. 6 cycles. Took a break and 4 months later the cancer grew back. I have just started Cisplatin. The first treatment did make me feel nauseous even on the anti nausea meds. Not looking forward to the next treatment.

Differences in type of Uterine cancers

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