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Various immunoassay methods for CA 125

Abbycat2's picture
Abbycat2
Posts: 644
Joined: Feb 2014

Good Morning, Ladies,

I have had three CA-125 immunoassay tests done and each one used a different method to obtain the results.  It is confusing and frustration because I don't think these various methods for assessing the CA-125 can be compared with one another.  My first CA-125 test was done in November, 2013, following my hysterectomy and using the Siemens Advia Centaur chemiluminescent method, which yielded a test result of 22.  The reference range for this method is <35.  My second CA-125 was done in March, 2014, using the Siemens chemiluminescent method with a reference range of <21 and my test result was 8.  Now, this month I had a CA-125 test using the Beckman Coulter chemiluminescent method with a reference range of <35 and my test result was 11.   I know that all of my test results are within normal range, but beyond that I can't compare them.  Have any of you had similiar experiences?  I will be discussing this further with my doctors as I want my test to be done using one method only so that I can compare them.

Have a wonderful day!

Cathy

Ro10's picture
Ro10
Posts: 1579
Joined: Jan 2009

I haveno idea what method is used to test my CA 125.  I know different labs can give different Results.   As long as you are getting normal results, I would not be concerned.  All of your results are well below the normal high.  You could have those tests drawn two days in a row and get different results.  Are you lab tests all drawn at the same facility?

hope you are having a good day

Abbycat2's picture
Abbycat2
Posts: 644
Joined: Feb 2014

Ro, the last two tests were drawn from the same facility but using different methods.  I am going to discuss this further with my gyn oncologist next Tuesday when I see him.

Thanks ,

Cathy

 

Kaleena's picture
Kaleena
Posts: 2033
Joined: Nov 2009

Hi Cathy:

I just saw in one of my recent CA125 testings that the test had changed and that the new readings are lower than the readings that I had done in 2005 and 2006.   I believe the changes went into effect sometime in 2011.   It can be quite confusing.   Like you, all of my readings have been in the normal range.

Kathy

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