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oxi

kennyt's picture
kennyt
Posts: 110
Joined: Jun 2013

How important is the oxi in the chemo mix?

Sundanceh's picture
Sundanceh
Posts: 4408
Joined: Jun 2009

that drug is the main ingredient in the Folfox combo...considered a 1st line drug...platinum based...

kennyt's picture
kennyt
Posts: 110
Joined: Jun 2013

so would that be the most important drug in the xelox avastin mix? i'm just curious after my first infusion I had minimal side effects hopefully that continues

lp1964's picture
lp1964
Posts: 1238
Joined: Jun 2013

I have to double check but what I read was that the cancer fighting drug is still the Xeloda (5-FU). Oxalyplatin makes the 5-FU stay in the cell longer, increasing its efficiency. 

Folfox hit me a little harder then Xeloda. Nothing in my fingers or toes, but I'm a little more shaky, my voice was a little horsey for a couple of hours and I got those zings in my jaw when started eating. These effects are accumulative, so we have to watch out for the next few times.

Laz

kennyt's picture
kennyt
Posts: 110
Joined: Jun 2013

my second infusion the fingers and toe are very tingly I hope this subsides hard to even use a pencil

lp1964's picture
lp1964
Posts: 1238
Joined: Jun 2013

...Kenny. I'm getting my second dose next Monday and that's very concerning. As you know I'm a dentist holding fine instruments and making fine movements with my hands. I'll talk to my doctor, maybe we could reduce the dose a little.

Lets hang in there man. I wish you a quick recovery.

Laz

BusterBrown's picture
BusterBrown
Posts: 221
Joined: Mar 2005

 

When I was dx'd in 2004 with crc and liver mets my Onc put me on Folfox. After 3/4 doses I had a CT and the 3 spots on my liver were gone. For me, Folfox has worked well. Fast forward to 2013, I'm on Folfox again to combat some more liver mets. After my 4th dose, Folfox has made a dramatic improvment.  

To answer your question, it's been very important to me...

 

Buster

kennyt's picture
kennyt
Posts: 110
Joined: Jun 2013

Laz, I had minor finger stuff and the room temp drinks lasted about 3-4 days

Trubrit's picture
Trubrit
Posts: 5045
Joined: Jan 2013

they can be accumulative. As usual, it all depends on the individual. 

The jaw zingy thing went away real quick as did the throat constriction when drinking cold liquids.  The cold sensitivity went away quickly too but all of these were replaced by equally or worse side effects; Thrush and fatigue being the worst.  I lost my hair too.

I should be having my first post treatment CT scan in the next couple of weeks, and hopefully I can report as BusterBrown, and say that it worked for me. 

Good luck as you continue this journey. 

kennyt's picture
kennyt
Posts: 110
Joined: Jun 2013

I'm holding out for minimal side effects for us all. good luck with your ct

db8ne1's picture
db8ne1
Posts: 141
Joined: Feb 2013

As stated in a previous post, oxi helps the 5FU to be more effective.  That said, it's a lot more toxic than the 5FU.  So, you have to weigh the benefits with the potential long term (possibly permanent side effects). 

I suggest keeping a log of side effects and discussing with your oncologist prior to every round.  Some people tolerate the oxi well and can handle it well for the full 12 rounds.  I saw a post from 1 member here who had a horrible reaction during round 1 and her doc cut the oxi completely from her regimen.  I've seen many more posts from people who had very few side effects and worked full time throughout.   My 1st 3 rounds produced horrible side effects (pain being the worst).  Affter round 3 my legs would go out on me, my hands cramped closed, as did my lips - among other side effects.  So, Round 4 the onc cut the oxi back by 25%.  That helped.  I just had round 7 this past Wednesday - so I'm good with only getting 75% of my recommended dosage of oxi and hoping I can stay that way to the end.

That said, everyone is different.  You may just breeze through the rounds.  I pray you do!

Best,

Jenni

MaryCarol5's picture
MaryCarol5
Posts: 102
Joined: May 2013

I am one of those rare ones that had a horrible reaction to the oxy- so bad in fact that it scared my onc.  I will not revisit it unless the cancer returns. 

I hope that noone else has such a hard time and can tolerate it long enough to increase their chances of NED!

MC

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