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Apr 08, 2013 - 1:23 pm
I'm sure moreinfo is already available http://medicalxpress.com/news/2013-04-xl-cabozantinib-for-colorectal-cancer.html and from the same conference http://medicalxpress.com/news/2013-04-biomarker-patients-autophagy-inhibitors.html this one above might be very useful and one below piK3CA while last two do not specify CRC,nevertheless CRC does involve these pathways,genes
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Joined: Oct 2010
skipping the line
I am always interested to see these papers with the specific antibodies and kinase inhibitors blocking a particular oncogenic pathway. However I feel that instead of waiting we can skip ahead for 5-10 cents a day with less side effects with natural type molecules for cancer inhibitors. We can even afford to carpet bomb multiple pathways with nutritional substances that may stack, and play nicely together, while skipping the line.
In one part of the first reference above, cMet and Met are mentioned as targets. EGCG in green tea extract has been shown to inhibit Met/cMet for several epithelial cancers including some colon cancers.
Joined: Oct 2009
EGCG is one of the supplements i've been taking (tho i think
i had been doing so prior to Dx as i was taking tons of stuff as i knew back then my diet was lousy-eat more fruit and vegs in one day now than i used to in a month)Used to get the LEF magazine free by mail but didn't continue when they wanted subscritption;a local health food store my girlfriend goes to used to have copies but doesn;t anymore;articles well-documented.
Joined: Oct 2009
another potential AKT inhibitor:ARQ 092
http://medicalxpress.com/print284710890.html
and on adding cetuximab to chemo
www.dailyrx.com/cetuximab-and-chemo-make-surgery-possible-colorectal-cancer-liver-mets