"XL-184 (Cabozantinib) goes 12-for-12 in colorectal cancer explants" and more on CRC fromAACR meetin

coloCan

I'm sure moreinfo is already available

http://medicalxpress.com/news/2013-04-xl-cabozantinib-for-colorectal-cancer.html

and from the same conference

http://medicalxpress.com/news/2013-04-biomarker-patients-autophagy-inhibitors.html

http://ecancer.org/news/3998-aacr-2013--study-indicates-novel-inhibitor-to-overcome-drug-resistance-induced-by-raf--mek-inhibitors.php

this one above might be very useful and one below piK3CA

http://ecancer.org/news/3995-aacr-2013--akt-inhibitor-azd5363-well-tolerated--yielded-partial-response-in-patients-with-advanced-solid-tumours.php

while last two do not specify CRC,nevertheless CRC does involve these pathways,genes

 

 

 

tanstaafl

skipping the line

I am always interested to see these papers with the specific antibodies and kinase inhibitors blocking a particular oncogenic pathway.  However I feel that instead of waiting we can skip ahead for 5-10 cents a day with less side effects with natural type molecules for cancer inhibitors.  We can even afford to carpet bomb multiple pathways with nutritional substances that may stack, and play nicely together, while skipping the line.

In one part of the first reference above, cMet and Met are mentioned as targets.   EGCG in green tea extract has been shown to inhibit Met/cMet for several epithelial cancers including some colon cancers.  

coloCan

tanstaafl said:

skipping the line

I am always interested to see these papers with the specific antibodies and kinase inhibitors blocking a particular oncogenic pathway.  However I feel that instead of waiting we can skip ahead for 5-10 cents a day with less side effects with natural type molecules for cancer inhibitors.  We can even afford to carpet bomb multiple pathways with nutritional substances that may stack, and play nicely together, while skipping the line.

In one part of the first reference above, cMet and Met are mentioned as targets.   EGCG in green tea extract has been shown to inhibit Met/cMet for several epithelial cancers including some colon cancers.  

EGCG is one of the supplements i've been taking (tho i think

i had been doing so prior to Dx as i was taking tons of stuff as i knew back then my diet was lousy-eat more fruit and vegs in one day now than i used to in a month)Used to get the LEF magazine free by mail but didn't continue when they wanted subscritption;a local health food store my girlfriend goes to used to have copies but doesn;t anymore;articles well-documented.

coloCan

coloCan said:

EGCG is one of the supplements i've been taking (tho i think

i had been doing so prior to Dx as i was taking tons of stuff as i knew back then my diet was lousy-eat more fruit and vegs in one day now than i used to in a month)Used to get the LEF magazine free by mail but didn't continue when they wanted subscritption;a local health food store my girlfriend goes to used to have copies but doesn;t anymore;articles well-documented.

another potential AKT inhibitor:ARQ 092

http://medicalxpress.com/print284710890.html

and on adding cetuximab to chemo

www.dailyrx.com/cetuximab-and-chemo-make-surgery-possible-colorectal-cancer-liver-mets