Zaltrap(aflibercept)given expedited review by FDA

coloCan
coloCan Member Posts: 1,944 Member
edited April 2012 in Colorectal Cancer #1
for mCRC thats been previously treated with oxy regimens

inpharm.com/print/172095

Comments

  • pepebcn
    pepebcn Member Posts: 6,331
    Don't understand statics , just one month of extra
    survival compared to placebo? Do you understand it Steve ? Is this placebo another active drug or just water? i mean nothing .
  • coloCan
    coloCan Member Posts: 1,944 Member
    pepebcn said:

    Don't understand statics , just one month of extra
    survival compared to placebo? Do you understand it Steve ? Is this placebo another active drug or just water? i mean nothing .

    Have no idea what placebo composed of in this case
    but apparently nothing else available appears to help so any increase in survivability (same applies to Regorafenib,which also improved survival abit after all else failed to do so)is deemed significant, keeping in mind that some will do better and others worse..Are we just grasping at straws here?- i don't know
  • smokeyjoe
    smokeyjoe Member Posts: 1,425
    coloCan said:

    Have no idea what placebo composed of in this case
    but apparently nothing else available appears to help so any increase in survivability (same applies to Regorafenib,which also improved survival abit after all else failed to do so)is deemed significant, keeping in mind that some will do better and others worse..Are we just grasping at straws here?- i don't know

    I have a dumb question,
    I have a dumb question, when they say progression free survival....do they mean you are progression free while on the drug? Or do they mean you do a certain amount of treatments, stop the drug and measure progression from that time forward?
  • smokeyjoe
    smokeyjoe Member Posts: 1,425
    coloCan said:

    Have no idea what placebo composed of in this case
    but apparently nothing else available appears to help so any increase in survivability (same applies to Regorafenib,which also improved survival abit after all else failed to do so)is deemed significant, keeping in mind that some will do better and others worse..Are we just grasping at straws here?- i don't know

    I have a dumb question,
    I have a dumb question, when they say progression free survival....do they mean you are progression free while on the drug? Or do they mean you do a certain amount of treatments, stop the drug and measure progression from that time forward?
  • coloCan
    coloCan Member Posts: 1,944 Member
    smokeyjoe said:

    I have a dumb question,
    I have a dumb question, when they say progression free survival....do they mean you are progression free while on the drug? Or do they mean you do a certain amount of treatments, stop the drug and measure progression from that time forward?

    good question for which i don't have good answer to
    Supposedly,your situation doesn't get worse but I don't every recall reading anywhere whether one remains in treatment or not.....Since the stuff in phase III trials probably hasn't been in use too long, I wonder for how long those taking such drugs are monitored? Maybe someone else can answer your question.....However "dumb" you think you are,how "dumber" am I without an answer?

    I think the last addition to the FDA's CRC arsenal was in 1996......
  • PhillieG
    PhillieG Member Posts: 4,866
    What my Niece was working on...
    Here's a link to a press release for the new drug trial my niece and her team have been working on.
  • coloCan
    coloCan Member Posts: 1,944 Member
    PhillieG said:

    What my Niece was working on...
    Here's a link to a press release for the new drug trial my niece and her team have been working on.

    Among the many unsung heroes in the battle against cancer.....
    We all thank (or maybe curse)our doctors while forgetting all those in the trenches,including those participating in trials,whose conscientious efforts every now and then bring forth something that truly saves lives....Hoping thats the case here......Must be proud of her Phil.....