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XELIRI regimen questions

traci43's picture
traci43
Posts: 775
Joined: Jul 2007

Hi all - Yesterday I had my first round of irinotecan and avastin. Today I start xeloda, 4 pills 2x a day for seven days. Off for a week, then back in for another round. Most folks seems to do two weeks and off one, so I'm wodnering if anyone is doing one on, one off? I did one round of oxy, avastin and xeloda in January 2009 and got foot blisters on day 14. I wanted to try it again because the fatigue is so much less than with 5-FU pump. My onc is doing it this was to hopefully minimze the blistering so I can stay on it.

Last night I was really tired and nauseous, even with taking 2 compazine. This morning I feel much better, but still some mild waves of nausea after taking Zofran. I need to go eat and take the Xeloda.

Here's hoping that the new regimen, kicks some cancer butt! Traci

msccolon's picture
msccolon
Posts: 1956
Joined: Oct 2004

I haven't done Xeloda, but I never got any relief from compazine, and none from zofran on chemo. Emend/decadron combo was the only thing that worked for the chemo nausea for me. Funmny, zofran works fine for me for other types of nausea, just never for the chemo nausea. I sure hope this regimen works well for you! Talk to your doc about getting better control of the nausea, it really makes a big difference on how we feel about our chemo days! Stay strong and I continue to pray for you, we seem to be on similar tracks!
mary

traci43's picture
traci43
Posts: 775
Joined: Jul 2007

Thanks Mary - Yes, I will definitely mention the nausea next time I go in. I can't do the steriods because of my acid reflux--it actually makes matters worse. At least I feel like I can do things today, whereas yesterday was very slow. Take care, traci

msccolon's picture
msccolon
Posts: 1956
Joined: Oct 2004

Wow, I hope they can get something that WILL work for you then next time! So glad you are getting to feel better today, pray it continues!
mary

Brenda3.16
Posts: 211
Joined: May 2009

I am on the same schedule as you. Xeloda on for 7 days off for 7 days. Irronoteacan and avastin every every week. I asked my onc about the schedule, when I noticed many others were on the 3 week schedule. He said that it is based on the Xeloda schedule, which he feels is better on a two week cycle.

I found that Emend really helped me with the nauseau. I also got delayed diarreah which they are going to start giving me a shot of something once a month that is supposed to help.

I did lose all of my hair on this treatment, but many others did not. I got a good wig and actually got over it very quickly, which surprised me.

Good Luck. Brenda

ktlcs's picture
ktlcs
Posts: 360
Joined: Jan 2010

My husband was on the same, 1 week on 1 off and he tolerated it very well. One hint take it 30 minutes after you eat not right before and not while your eating, stomach seems to accept it much better that way

traci43's picture
traci43
Posts: 775
Joined: Jul 2007

Last night and this morning I ate almost everything then took the pills. Much better. The first time I just did not eat enough--not even 1/2 a muffin. Needless to say I learned my lesson. Thanks, Traci

traci43's picture
traci43
Posts: 775
Joined: Jul 2007

I am a bit worried about the hair loss. I'm glad you were able to deal with it. Not sure I could! Thanks for the insight, Traci

AnneCan
Posts: 3692
Joined: Oct 2009

I lost most of my hair with irenotecan, but then it started growing back. It did not bother me as much as I thought it would + it has been fun watching it grow back.

AnneCan
Posts: 3692
Joined: Oct 2009

Good for you!

taraHK
Posts: 1961
Joined: Aug 2003

Hi. I'm on Xeliri plus Avastin. I have a slightly different schedule. I do the irinotecan and avastin every 2 weeks. For the Xeloda, I take 3 pills, 2x/day. I do 4 days on, 3 days off (then repeat) -- should equal 14 days! I started with 5 days on, 2 days off, but I am having 'moderate' hand-foot syndrome from the Xeloda. Just FYI -- I'm aware that there are different schedules -- whatever works!

I'm tolerating the regime pretty well. My main complaint is hand-foot (from Xeloda). I had some acute diarrhea from irinotecan but that settled down (not sure why). Some fatigue.

Interesting fact -- my hair lasted until cycle 10/11 -- just started wearing a wig this week (and my family/loved ones promised me to be brutally honest about "it's time"). So I lasted longer than I'd thought.

Good luck, Xeliri friends!

Love,
Tara

ritaclough's picture
ritaclough
Posts: 44
Joined: Sep 2010

Reeds all natural ginger RX for nausea. Relieves nausea without drowsines for me :~) I also drink their ginger ale which is yummy and helps

http://www.reedsinc.com/reeds-rx/

ritaclough's picture
ritaclough
Posts: 44
Joined: Sep 2010

Oh and my hair thinned from my last chemo regimen a year ago to the point I needed a wig. I am now on my second round of chemos and suspect I'll lose it again...oh well heehee... I went threw a few wigs before I found just the right one but I'm still wearing my wig as I love it!!!! Get a good wig not a cheap one and you will be amazed...I think I'm a lifer in a wig now....its better then my real hair ever thought of being lol

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