Firmagon (Degarelix) substitute for Lupron
Comments
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PETERBILT OR?Medcomglen said:Peterbilt hit me
Hi Les,
Congratulations on catching your nine pounder. That must have been a gas pulling that one in. My daughter bets me when we go fishing and usually empties my wallet I hate to admit. They are special times for sure. Great photo and you look great by the way. Handsome fish too.
Got my Firmagon injection Friday and it feels like a Peterbilt hit me. More refined this time … a perfectly raised itchy red patch about 2”W and 3”L. It’s better today but still warm and tender. No other side effects yet.
Keep fishing…
Glen
Hi Glen......Sorry you got the 'ol PETERBILT symptom again :-((.........I try to just keep on truckin' when I get my shot..........my wife lets me whine for a day or two unless I go fishing. Then she thinks I'm well again..........but hey, it beats the alternative. Goin' fishin' again tomorrow. I try to get out twice a week......early; about 5am and quit before the high heat. We live in North Central arkansas and it's been warm lately......but the fishin' has been good. Have a great day/week.
keep on livin' it up :-))............Les0 -
Hormone implantsMedcomglen said:Peterbilt hit me
Hi Les,
Congratulations on catching your nine pounder. That must have been a gas pulling that one in. My daughter bets me when we go fishing and usually empties my wallet I hate to admit. They are special times for sure. Great photo and you look great by the way. Handsome fish too.
Got my Firmagon injection Friday and it feels like a Peterbilt hit me. More refined this time … a perfectly raised itchy red patch about 2”W and 3”L. It’s better today but still warm and tender. No other side effects yet.
Keep fishing…
Glen
My Uncle got an hormone implant for his pca that lasts much longer then the painful shots. Is that not an option for you?0 -
Firmagon and CasodexMedcomglen said:Peterbilt hit me
Hi Les,
Congratulations on catching your nine pounder. That must have been a gas pulling that one in. My daughter bets me when we go fishing and usually empties my wallet I hate to admit. They are special times for sure. Great photo and you look great by the way. Handsome fish too.
Got my Firmagon injection Friday and it feels like a Peterbilt hit me. More refined this time … a perfectly raised itchy red patch about 2”W and 3”L. It’s better today but still warm and tender. No other side effects yet.
Keep fishing…
Glen
This is my first posting on this board although I've been reading it for the past few months.
I was diagnosed with prostate cancer May of 2007. I chose cryosurgery to deal with the problem. Recovery from the procedure was slow and uncomfortable lasting about 9 weeks before they could remove the pubic cathetor. In hindsight, I wish I had chosen radical surgery.
My PSA was undetectable for about 6 months but then began to rise. My urologist started me on Lupron every 4 months. This worked quite well bringing my PSA down to 0.2 after 5 months. We tried staying off Lupron for 6 months with the thought that perhaps intermittent treatment would prolong the effectiveness. In May 2008, my PSA had risen again to 3.1 so we started it back up again. Once again the PSA went down but this time only to about 0.7. A bone scan was done and showed spots on a couple ribs and also the pubic bone. The doctor started me on Casadex along with continued Lupron injections. By May of 2010 my PSA was up to 5.1 so I was given my first two injections of Firmagon. He continued a one a day Casadex. My next Firmagon was exactly 5 weeks later because of travel scheduling and my PSA had risen to 12.9!!. I was really disappointed because I'd been reading the experience of the men on this board having such great success with Firmagon. Thinking perhaps a mistake had been made, I went to another lab and had a PSA done which was only 3 days later and the reading was 7.2. A drop from 12.9 to 7.2 in three days had me hopeful it was working this time. During those 3 days I had quit taking Casodex as per my doctors instructions. He later changed his mind and put me back on Casodex when his lab results came back showing my testosterone level at 34. I had blood drawn a couple days ago (3 1/2 weeks from the previous one) and my PSA was 12.6 almost unchanged from the last one at his lab. I get my next Firmagon this Friday which will be exactly 4 weeks from the previous one.
I hope this background data isn't too confusing. The question in my mind and am wanting input on from this board is this. Is it possible that Casodex fights the effectiveness of Firmagon? Have any of you had a discussion with your doctor on this subject? I appreciate and look forward to any input.
Frank0 -
Fimagon & CasodexAKFrank said:Firmagon and Casodex
This is my first posting on this board although I've been reading it for the past few months.
I was diagnosed with prostate cancer May of 2007. I chose cryosurgery to deal with the problem. Recovery from the procedure was slow and uncomfortable lasting about 9 weeks before they could remove the pubic cathetor. In hindsight, I wish I had chosen radical surgery.
My PSA was undetectable for about 6 months but then began to rise. My urologist started me on Lupron every 4 months. This worked quite well bringing my PSA down to 0.2 after 5 months. We tried staying off Lupron for 6 months with the thought that perhaps intermittent treatment would prolong the effectiveness. In May 2008, my PSA had risen again to 3.1 so we started it back up again. Once again the PSA went down but this time only to about 0.7. A bone scan was done and showed spots on a couple ribs and also the pubic bone. The doctor started me on Casadex along with continued Lupron injections. By May of 2010 my PSA was up to 5.1 so I was given my first two injections of Firmagon. He continued a one a day Casadex. My next Firmagon was exactly 5 weeks later because of travel scheduling and my PSA had risen to 12.9!!. I was really disappointed because I'd been reading the experience of the men on this board having such great success with Firmagon. Thinking perhaps a mistake had been made, I went to another lab and had a PSA done which was only 3 days later and the reading was 7.2. A drop from 12.9 to 7.2 in three days had me hopeful it was working this time. During those 3 days I had quit taking Casodex as per my doctors instructions. He later changed his mind and put me back on Casodex when his lab results came back showing my testosterone level at 34. I had blood drawn a couple days ago (3 1/2 weeks from the previous one) and my PSA was 12.6 almost unchanged from the last one at his lab. I get my next Firmagon this Friday which will be exactly 4 weeks from the previous one.
I hope this background data isn't too confusing. The question in my mind and am wanting input on from this board is this. Is it possible that Casodex fights the effectiveness of Firmagon? Have any of you had a discussion with your doctor on this subject? I appreciate and look forward to any input.
Frank
Hi Frank
I cannot give an answer you requested but your post is of great interest to me because you have previously been on Casodex and Lupron which is the present treatment I am on. Yesterday my PSA is down to 6.5 ( my history is posted way up the line here somewhere) and testosterone level is 4. I take the Lupron every 28 days and one casodex every day so I wonder why your doctor switched you to Fimagon???????
Perhaps it takes a few injections of Fimagon to start working for you( when I restarted Lupron my psa also went up for a couple of month before starting to reduce) so hang in there and please continue to post your results for us. many thanks
Bob0 -
My father takes Casodex and Vantasretired1 said:Fimagon & Casodex
Hi Frank
I cannot give an answer you requested but your post is of great interest to me because you have previously been on Casodex and Lupron which is the present treatment I am on. Yesterday my PSA is down to 6.5 ( my history is posted way up the line here somewhere) and testosterone level is 4. I take the Lupron every 28 days and one casodex every day so I wonder why your doctor switched you to Fimagon???????
Perhaps it takes a few injections of Fimagon to start working for you( when I restarted Lupron my psa also went up for a couple of month before starting to reduce) so hang in there and please continue to post your results for us. many thanks
Bob
My father is taken Casodex 2 times per day on a even day and 3 times per day on an odd day and has the Vantas implant for almost 3 years. His PSA was estable for a short period of time. The last PSA level as of last week is 222.2. Now the Oncologist is changing from Casodex to Nizoral 2 tablets twice a day and an steroid twice a day. The Oncologist is trying other medications until insurance agreeds to cover the cost of Provenge.
My dad has an appointment with his Urologist next week and will ask if it's better to try Lupron or Firmagon instead of Vantas. Vantas is convinient and has reduces my father's testetorone to 0, but the PSA continues risen.0 -
Fishing helpswayne2 said:PETERBILT OR?
Hi Glen......Sorry you got the 'ol PETERBILT symptom again :-((.........I try to just keep on truckin' when I get my shot..........my wife lets me whine for a day or two unless I go fishing. Then she thinks I'm well again..........but hey, it beats the alternative. Goin' fishin' again tomorrow. I try to get out twice a week......early; about 5am and quit before the high heat. We live in North Central arkansas and it's been warm lately......but the fishin' has been good. Have a great day/week.
keep on livin' it up :-))............Les
Hi Les,
The stomach pain subsided after five days and I only have a 2" red and round tender node now. The hot flashes started but not as severe as in the past. Overall I feel pretty good and fishing with my daughter is good therapy. We live in west central florida on the gulf and fish the intracoastal waters. We use to freshwater fish but the gators kept stealing my bass off my stringer :-)
Live Healthy,
Glen0 -
repeatwayne2 said:PETERBILT OR?
Hi Glen......Sorry you got the 'ol PETERBILT symptom again :-((.........I try to just keep on truckin' when I get my shot..........my wife lets me whine for a day or two unless I go fishing. Then she thinks I'm well again..........but hey, it beats the alternative. Goin' fishin' again tomorrow. I try to get out twice a week......early; about 5am and quit before the high heat. We live in North Central arkansas and it's been warm lately......but the fishin' has been good. Have a great day/week.
keep on livin' it up :-))............Les0 -
Hormone Implantgkoper said:Hormone implants
My Uncle got an hormone implant for his pca that lasts much longer then the painful shots. Is that not an option for you?
Hi Gkoper,
Are you referring to Vantas? There's been some discussion on these boards but unfortunatly I don't do well with the Lupron type therapy drugs and it's a twelve month dosing sequence. I'm preferring intermittent therapy to reduce hormonal side effects and prolong the hormone refractory situation.0 -
Firmagonretired1 said:Fimagon & Casodex
Hi Frank
I cannot give an answer you requested but your post is of great interest to me because you have previously been on Casodex and Lupron which is the present treatment I am on. Yesterday my PSA is down to 6.5 ( my history is posted way up the line here somewhere) and testosterone level is 4. I take the Lupron every 28 days and one casodex every day so I wonder why your doctor switched you to Fimagon???????
Perhaps it takes a few injections of Fimagon to start working for you( when I restarted Lupron my psa also went up for a couple of month before starting to reduce) so hang in there and please continue to post your results for us. many thanks
Bob
Hello Bob,
Thanks for your response to my post. To answer your question, my doctor started me on Firmagon because my body seemed to be developing an immunity to Lupron. After having worked quite well for the past two years, my PSA had risen from 0.2 to 5.2. Seeing my PSA at 12+ after two treatments, I have to wonder if it is any better for me than Lupron. Your experience of an increase in PSA the first few injections after having been off for a while and then to see it start to go down again gives me encouragement that perhaps Firmagon can work the same way.
I had my third treatment of Firmagon day before yesterday. The soreness in my stomach is a little less than last time and I'm hopeful the reaction each injection will be less. If it works, who cares about the discomfort. I kind of like living.
Looking at your previous posts, I see you had your seed implants in 1998. That's a remarkable amount of time and it looks like the hormone therapy is working well for you. I hope for your continued success.
Yes, I'll post my progress in regard to PSA reduction and whatever else I can share as they develop.0 -
Vantas and LupronNoniu said:My father takes Casodex and Vantas
My father is taken Casodex 2 times per day on a even day and 3 times per day on an odd day and has the Vantas implant for almost 3 years. His PSA was estable for a short period of time. The last PSA level as of last week is 222.2. Now the Oncologist is changing from Casodex to Nizoral 2 tablets twice a day and an steroid twice a day. The Oncologist is trying other medications until insurance agreeds to cover the cost of Provenge.
My dad has an appointment with his Urologist next week and will ask if it's better to try Lupron or Firmagon instead of Vantas. Vantas is convinient and has reduces my father's testetorone to 0, but the PSA continues risen.
Hello Noniu,
I asked my doctor about Vantas and he wasn't very enthusiastic. I got the impression that his clinic hadn't used it much. It's kind of hard to remember everything these doctors say but I think he said that Vantas and Lupron are for lack of a better word of the same family of hormone treatment. Firmagon apparently is different. All things being equal and having had both, I would prefer Lupron being it can be given in a stronger dosage to last 4 months. In your father's case, perhaps Firmagon would be a better choice being his PSA has gone up to 222 on Vantas. It's something to ask his doctor about.
In regard to Provenge, I am not very hopeful that medicare will approve it any time soon. That's just my opinion but at $93,000 for the treatment and only extending life by 4 months, it's understandable. Of course, the study group whose life was only extended on average 4 months were patients who had become resistant to hormone therapy and had already received chemo. In other words, they were pretty far gone. It begs the question, what results would be obtained with earlier stage prostate cancer patients.
Please keep us informed of what the doc recomends and what the results are.
Regards,
Frank0 -
FISHING HELPS ME TOOMedcomglen said:Fishing helps
Hi Les,
The stomach pain subsided after five days and I only have a 2" red and round tender node now. The hot flashes started but not as severe as in the past. Overall I feel pretty good and fishing with my daughter is good therapy. We live in west central florida on the gulf and fish the intracoastal waters. We use to freshwater fish but the gators kept stealing my bass off my stringer :-)
Live Healthy,
Glen
A friend and I caught over forty fish this am on topwater.....very unusual for this time of the year. The surface temp is 90 degrees.What a great time we had; never once thought about cancer :-)).........until I started reading the blogs here again, but the words here give me great hope..........kind of like prayers :-))Thanks again for all your encouraging words and info. I get my next firmagon shot next Tuesday. It'll be my fifth month of the shots.......and the side effects seem ok, considering the alternative :-))Get my next psa test in a couple of months. Sounds like your fishing is different than mine; we don't have gators,etc.
wishing you more happy "daughter therepy",
Les0 -
PSA 0.0Medcomglen said:Rising PSA
Katman,
Glad you didn't experience any injection pain. I don't look forward to another injection but... I had a good run since August '09 with Firmagon so I guess I can't complain.
Received my new test results today and my PSA doubled in two months.
5/12/10 PSA: 2.8
7/9/10 PSA: 5.79
Just had my first blood work since starting Firmagon in May and the PSA is down to 0.0. Can't get better then that. The urologist originally said that I would go for a year on the injections. Don't know if he'll want to continue injections but I assume he will.0 -
MY OWN MACK TRUCKMedcomglen said:Fishing helps
Hi Les,
The stomach pain subsided after five days and I only have a 2" red and round tender node now. The hot flashes started but not as severe as in the past. Overall I feel pretty good and fishing with my daughter is good therapy. We live in west central florida on the gulf and fish the intracoastal waters. We use to freshwater fish but the gators kept stealing my bass off my stringer :-)
Live Healthy,
Glen
Hi Glen...I haven't written for a while and also haven't seen anything from you for a while....I hope all is going well for you.
I had another firmagon shot last thursday............a real Mack Truck as you say.
I'm now taking Plavix for some moderate arteriosclerosis(sp?)......and it SURE enlarges the red area around the 'ol tummy shot..........and I REALLY try not to touch it for a few days.
But, hey, I went fishing the next morning at 6am.......didn't catch much tho.......one of those "humbling" experiences, but it was beautiful out on the water.
hope you're having some fun.
Les0 -
On my way...
Hi Glen
I have an appointment with my urologist this Thursday. I fill you in on my exerience as soon as I can. Hope all is well with you.
Bob0 -
newguyLeesburgBob said:On my way...
Hi Glen
I have an appointment with my urologist this Thursday. I fill you in on my exerience as soon as I can. Hope all is well with you.
Bob
Hi guys,
Im new to this forum and was diagnosed with PC in mid august. Im a 48 yr old fireman have a wife and three beautiful kids. I originally went to see a urologist for typical BPH type problems (frequent urination and clear discolored ejaculate.I just new deep down that something was wrong.Well,digital exam and PSA (8.4) revealed problems.Had a Biopsey done (ouch)and got the news mid august. 11 of my 12 biopseys tested positive for adenocarcinoma.Gleason score of 10(5+5).My world was rocked.Had lots of tests done in the last month bone scans ct scans MRI with probe,MRI of spine ultrasounds blood tests etc etc.They found stage 4 cancer with a prostate cancer lesion on my bladder and a suspitious lesion on my L4 lumbar that has yet to be confirmed.My urologist immediately put me on HT with degerelix.No major problems yet except for in the bedroom.I now enjoy sensitive chic movies,chocolates,shopping with my wife and just need to be held!!!LOL!!trying to stay positive and have great family and friends who are there for me no matter what.Reading your experiences on this forum is giving me hope for my treatment in managing this crap.I got my foot in the door at Sloan Kimmel center for prostate cancer in NYC.Dr.David Solit (Oncologist/researcher)is going to be asked a lot of questions this monday when I see him.I will keep you guys posted,thanks Wardy0 -
Welcomewardyboy said:newguy
Hi guys,
Im new to this forum and was diagnosed with PC in mid august. Im a 48 yr old fireman have a wife and three beautiful kids. I originally went to see a urologist for typical BPH type problems (frequent urination and clear discolored ejaculate.I just new deep down that something was wrong.Well,digital exam and PSA (8.4) revealed problems.Had a Biopsey done (ouch)and got the news mid august. 11 of my 12 biopseys tested positive for adenocarcinoma.Gleason score of 10(5+5).My world was rocked.Had lots of tests done in the last month bone scans ct scans MRI with probe,MRI of spine ultrasounds blood tests etc etc.They found stage 4 cancer with a prostate cancer lesion on my bladder and a suspitious lesion on my L4 lumbar that has yet to be confirmed.My urologist immediately put me on HT with degerelix.No major problems yet except for in the bedroom.I now enjoy sensitive chic movies,chocolates,shopping with my wife and just need to be held!!!LOL!!trying to stay positive and have great family and friends who are there for me no matter what.Reading your experiences on this forum is giving me hope for my treatment in managing this crap.I got my foot in the door at Sloan Kimmel center for prostate cancer in NYC.Dr.David Solit (Oncologist/researcher)is going to be asked a lot of questions this monday when I see him.I will keep you guys posted,thanks Wardy
WOW, Wardy, what a way to get your life rocked. And how many times can you watch "Pretty Woman" or "The Devil Wears Prada" anyway??? Seriously, you seem to have a wonderful attitude for facing this situation and it looks like you've heading someplace where there are a lot of experts to help you. Please keep us posted on your progress.0 -
At Sloan todayKongo said:Welcome
WOW, Wardy, what a way to get your life rocked. And how many times can you watch "Pretty Woman" or "The Devil Wears Prada" anyway??? Seriously, you seem to have a wonderful attitude for facing this situation and it looks like you've heading someplace where there are a lot of experts to help you. Please keep us posted on your progress.
Heard some good news and bad news at my meeting with my oncologist.The good news PSA went from 8.6 before treatment to 1.13 on 9/15 to .77 as of today(only 28 days of hormone therapy).My testoterone levels are 13 and dropping.The BAD news is that My MRIs showed Extremely advanced PC with new findings on the rectum wall/and lymph nodes.Previous exams showed PC involvement on the bladder and on L4 lumbar.My Oncologist wants to put me on Casodex along with my degerelix but my liver enzymes are elevated and wants to get those numbers down first. He thinks that my PC is causing high enzyme levels.No more red wine with dinner for now dammit. I guess pomegranite juice instead of Merlot!LOL.My Oncologist said some things that really scared me and a few things that give me hope but overall im feeling pretty scared and down,but this pity party wont last long!! I am going to kick the **** out of this cancer and piss on it!!!I am young strong and will be extemely aggressive in my treatment.Diet,exercise, continued hormone therapy, positive attitude,and radiation on the horizon. Oh and dont forget hunting and fishing with my kids and friends!!Thats good therapy too!!! stay well Wardy0 -
2nd shotwardyboy said:At Sloan today
Heard some good news and bad news at my meeting with my oncologist.The good news PSA went from 8.6 before treatment to 1.13 on 9/15 to .77 as of today(only 28 days of hormone therapy).My testoterone levels are 13 and dropping.The BAD news is that My MRIs showed Extremely advanced PC with new findings on the rectum wall/and lymph nodes.Previous exams showed PC involvement on the bladder and on L4 lumbar.My Oncologist wants to put me on Casodex along with my degerelix but my liver enzymes are elevated and wants to get those numbers down first. He thinks that my PC is causing high enzyme levels.No more red wine with dinner for now dammit. I guess pomegranite juice instead of Merlot!LOL.My Oncologist said some things that really scared me and a few things that give me hope but overall im feeling pretty scared and down,but this pity party wont last long!! I am going to kick the **** out of this cancer and piss on it!!!I am young strong and will be extemely aggressive in my treatment.Diet,exercise, continued hormone therapy, positive attitude,and radiation on the horizon. Oh and dont forget hunting and fishing with my kids and friends!!Thats good therapy too!!! stay well Wardy
I recieved my 2nd shot of Degerelix on Monday. No major discomfort,but have been feeling pretty down the last couple of days.Im wondering if it has to do with the fresh dose or if its just me.Some more results came in from mondays blood test.My testosterone went from 13 up to 17 in 2 weeks time. Is that a significant change?? Im not up om my testosterone info? Thanks Wardy0 -
You got the right atttude...wardyboy said:2nd shot
I recieved my 2nd shot of Degerelix on Monday. No major discomfort,but have been feeling pretty down the last couple of days.Im wondering if it has to do with the fresh dose or if its just me.Some more results came in from mondays blood test.My testosterone went from 13 up to 17 in 2 weeks time. Is that a significant change?? Im not up om my testosterone info? Thanks Wardy
Wardyboy,
After reading your initial post your positive attitude not only uplifted me but probably all the guys on this blog. Personally I was down in the dumps after receiving two Firmagon injections recently after my PSA jumped in two months from 2.7 to 5.9 but your enthusiasm has helped me to stop feeling sorry for my self if you can relate. Sucks when you cry after watching a Lexus commercial.
I think you're probably feeling the normal side effects of chemical castration. HORMONES Just wait till the moobs start growing LOL. Well at least we still have our humor.
You're a breath of fresh air and I look forward to your positive outlook and progress.
I'm not a Doctor but your slight rise in Testosterone isn't signicant. Mine was 68 while maintaining a 1- PSA score for several months.
Good Health<
G0 -
Keeping positve!Medcomglen said:You got the right atttude...
Wardyboy,
After reading your initial post your positive attitude not only uplifted me but probably all the guys on this blog. Personally I was down in the dumps after receiving two Firmagon injections recently after my PSA jumped in two months from 2.7 to 5.9 but your enthusiasm has helped me to stop feeling sorry for my self if you can relate. Sucks when you cry after watching a Lexus commercial.
I think you're probably feeling the normal side effects of chemical castration. HORMONES Just wait till the moobs start growing LOL. Well at least we still have our humor.
You're a breath of fresh air and I look forward to your positive outlook and progress.
I'm not a Doctor but your slight rise in Testosterone isn't signicant. Mine was 68 while maintaining a 1- PSA score for several months.
Good Health<
G
I have to keep positive to fight the good fight. I have a monster of PC to battle.When my Oncologist(who deals only with PC at Sloan),told me that im in the top 1% of most advanced PC that hes dealt with, I cried and im still reeling from it.I have only been dealing with this for 6 weeks and have been through a lot!!!My family,friends and brother Firefighters have rallied around me.The guys in the Firehouse are working my tours for as long as I need !Several of them have called me to let me know that they too are battling PC.My employee assistance counselor for my department has just been diagnosed with PC and wants to partner up with me to share info, support etc .How about that I might be counseling my counsler!!!LOL.I think that my next step is to talk a few oncologists.I dont feel "good" with my current guy. I just feel like another patient.Hes mainly a researcher for Sloan and only sees patients 1 day a week.When I asked about diet and supplements and what "I" can do to make my body as "unfriendly" to this cancer as possible,he didnt offer much.I am going to start researching this next and any recommendations that you guys can give would be appreciated. Thanks Wardy P.S. Nice tractor Glen ! My 56 yr old Farmall tractor is like an old friend,but I drool looking at the new ones!I might be down in your area soon. Going to sneak down to Sanibel Island with my wife for a long weekend for our anniversary.Cant wait to fish and swim in that warm gulf water!! Good therapy for sure!!!0
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