Any had experience with neuropathy as side effect in Folfiri or Avastin?

pepebcn
pepebcn Member Posts: 6,331 Member
edited March 2014 in Colorectal Cancer #1
last year l was on Folfox which caused me a severe neuropathy, after 10 rounds we had to stop due to the neuropathy.Now 8 months after been off folfox l still had certain high level of it on my feet an hands. Unofrtunadelly l am in recurrence and l have already started 5 days a go with Folfiri +avastin (first round) , my main concern is that today the existing old neuropathy is going worst, an lm a little beat worried ,as per the doctors it suppose no neuropathy use to be caused by my Folfiri nor Avastin.l would not like to have to search for a third plan !
Beside that no other major side effects for the moment (tks god).
Did any body had any kind of neurological problems caused by folfiri or avastin?Cut it be a different kind of syndrome? (feet&hands syndrome for example) What is the difference between neuropathy and feet and hands syndrome?
l will apreciate any comment to my post!
Best to every body!

Comments

  • abrub
    abrub Member Posts: 2,174 Member
    #2
    Hand-Foot Syndrome is caused by 5FU
    5FU is part of both Folfiri and FolFox, and does cause neuropathy - hand-Foot syndrome. The Oxaliplatin is the nasty part of Folfox that really does a major number, but I've had residual neuropathy from both the 5FU and the Oxaliplatin. I don't believe that the Avastin is contributing to your neuropathy problems.

    Have you been told to take supplemental vitamin B6, or possibly Alpha Lipoic Acid? I took B6 while on chemo, take the ALA now, tho I've heard of people taking it during chemo. Ask your dr for recommendations. I also found that foot massages helped tremendously.

    Good luck!
  • wmcbane
    wmcbane Member Posts: 33
    #3
    Try Alpha-Lipoic Acid
    I have been using it throughout my chemo. I'm on 5-FU and oxaliplatin. I have neuropathy, but it's relatively minor and usually wears off in the 2 weeks between treatments. I don't know if it's the alpha Lipoic acid or that's just the way the drugs affect me. I don't think it can hurt.
  • Unknown
    Unknown
    #4
    This comment has been removed by the Moderator
  • pepebcn
    pepebcn Member Posts: 6,331 Member
    #5
    unknown said:

    This comment has been removed by the Moderator

    thank you Kathy
    You are an angel taking care of our problems troubles and dubts.Thanks god no major gastric problems until now, no worries about blood pressure l been allways extremely low so after first round 11/7 good.My major concern is the neuropathy and (this is disguising but you sure understand me) a sudden bleeding from my rectus trough my leg , not in panic, was red clean and look fresh and not mixed in the poo.(sorry for that)hope were roids despite l hadn't until today but l suppose chemotherapy can make them appear!.
    By the way haw was the result for folfiri+avastin in your case?
    Thank you again my guardian angel!
  • ADKer
    ADKer Member Posts: 147
    #6
    pepebcn said:

    thank you Kathy
    You are an angel taking care of our problems troubles and dubts.Thanks god no major gastric problems until now, no worries about blood pressure l been allways extremely low so after first round 11/7 good.My major concern is the neuropathy and (this is disguising but you sure understand me) a sudden bleeding from my rectus trough my leg , not in panic, was red clean and look fresh and not mixed in the poo.(sorry for that)hope were roids despite l hadn't until today but l suppose chemotherapy can make them appear!.
    By the way haw was the result for folfiri+avastin in your case?
    Thank you again my guardian angel!

    Neuropathy
    Both 5FU and Xeloda even more aggravated residual neuropathy that I had in my feet. In my case, the aggravation from the Xeloda went away when the Xeloda was stopped. I am now doing the oxaliplatin again, which I assume is more responsible for any increase in neuropathy than the 5FU. I don't believe that Avastin has any impact on neuropathy.
  • msccolon
    msccolon Member Posts: 1,917 Member
    #7
    FOLFIRI and Avastin
    I have had this combo MANY times. After my initial resection, I was put on FOLFOX, but only completed 3 treatments due to complications and continued with just the 5FU and Leucovorin. I don't have any residual neuropathy, so I can't speak to whether or not the FOLFIRI would complicate this side effect. I did have mucho gastro issues from the 5FU and consumed mass quantities of lomotil and hyocyamine. Initially, there would be some apparent constipation, but I never even bothered with it, knowing that once the pump was disconnected, i would be running to the bathroom constantly. Hopefully you won't have too much discomfort and your neuropathy won't get any worse.
    mary
  • pepebcn
    pepebcn Member Posts: 6,331 Member
    #8
    msccolon said:

    FOLFIRI and Avastin
    I have had this combo MANY times. After my initial resection, I was put on FOLFOX, but only completed 3 treatments due to complications and continued with just the 5FU and Leucovorin. I don't have any residual neuropathy, so I can't speak to whether or not the FOLFIRI would complicate this side effect. I did have mucho gastro issues from the 5FU and consumed mass quantities of lomotil and hyocyamine. Initially, there would be some apparent constipation, but I never even bothered with it, knowing that once the pump was disconnected, i would be running to the bathroom constantly. Hopefully you won't have too much discomfort and your neuropathy won't get any worse.
    mary

    Mary thanks alot!
    You are an angel too !

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