Article showing FDA thinking of pulling Avastin OFF the market

This is interesting
But I believe it has proven successful for colon cancer + a few others - I think brain is one.

Buzzard said:

On another note...........
Its one of the reasons that my mother is able to see right now....It has lowered the blood pressure in her eye after Avastin injections to relieve the blood supply to blocked veins in the eyes causing high blood pressure behind the eye and vision loss...I heard it had just been approved for this use...I will be watching this one......

FDA will remove it for BREAST not CRC Cancer usage
as its already proven its effectiveness here , bearing in mind that each cancer type is different, besides each tumor of the same cancer being different. .....steve

see healthday.com

PS interested in the Cancer Genome project?....check site I suggested earlier--its worth navigating

coloCan said:

I think FDA will ultimately decide to not recommend Avastin be
used for certain type(s) of breast cancer as I think its still effective in others; as for its use for CRC, thats been established .

I HATE the sensationalism of the press!!!
Just to sell....

SHAME on AP for propagating this stuff!!!

From another source:

http://www.msnbc.msn.com/id/38324215/ns/health-cancer/

"Panel wants Avastin withdrawn for breast cancer
Health advisers say the popular drug's risks outweigh its benefits

A panel of cancer experts said Tuesday that the government should remove its endorsement of Roche's drug Avastin for breast cancer, after follow-up studies failed to show benefits for patients.

A Food and Drug Administration panel of experts voted 12-1 in favor of removing the drug's approval for use against breast cancer alongside chemotherapy.

The FDA is not required to follow the advice of its panel, though it often does.

The negative vote is the first major setback for a blockbuster cancer drug that has racked up approvals for half a dozen forms of the disease. Avastin is also approved for colon, lung, kidney and brain cancer. The panel's ruling only pertains to Avastin's use in breast cancer.

The FDA in 2008 approved Avastin for breast cancer patients based on a trial showing it extended the amount of time until the disease worsened by more than five months. The decision was considered controversial by some cancer doctors because the drug had not been shown to extend patients' lives.

As a condition of approval, Roche was required to conduct follow-up studies to demonstrate the benefits of adding Avastin to conventional chemotherapy.

But two follow-up studies recently submitted by the Swiss drugmaker did not show the same degree of delay in cancer progression as earlier studies. Additionally, patients taking Avastin did not show a significant improvement in lifespan, the gold standard of cancer treatment effectiveness.

Roche scientists argued Tuesday that patients taking Avastin experienced improved quality of life as tumor growth and other symptoms are delayed — but panelists were not convinced.

"The study shows there's very little benefit to patients with significant toxicity risks and no clear survival benefit," said Natalie Compagni Portis, the panel's patient representative.

Panelists said they worried the drug could do more harm than good because of serious side effects, including high blood pressure, fatigue and abnormal levels of white blood cells.

"I think the burden of proof is that a drug is helpful, not that it doesn't make patients worse," said panel chair Dr. Wyndham Wilson of the National Cancer Institute. "We have definitive evidence that Avastin causes harmful side effects and we've now seen a number of well-done studies that show no advantage to lifespan."

Breast cancer is the second most-common cause of cancer death among U.S. women, according to the Centers for Disease Control. Last year more than 40,000 deaths in the U.S. were attributed to the disease."




Hugs, Kathi