What are the options besides Folfox & Folfiri (and Avastin) if KRAS-mutant?

KFen725
KFen725 Member Posts: 108 Member
edited March 2014 in Colorectal Cancer #1
My mom is Stage IV dx June 09 with mets to the liver, and did 4 treatments of Folfox (and Avastin some of the time) before finding that it was only keeping things stable & was not shrinking anything.

She is currently on Folfiri and will have her first followup scan to look at its effects in a few weeks. She also just found out that she is KRAS-mutant.

I am wondering, are there currently any other chemo regimes or other drugs available after Folfox & Folfiri for those who are KRAS-mutant?


Thanks,
Kelly

Comments

  • luv3jay
    luv3jay Member Posts: 533 Member
    #2
    I'm KRAS mutant, and i don't
    I'm KRAS mutant, and i don't think there are any other options except clinical trials. Hopefully the Folfiri will work for her.

    -Sheri
  • KFen725
    KFen725 Member Posts: 108 Member
    #3
    luv3jay said:

    I'm KRAS mutant, and i don't
    I'm KRAS mutant, and i don't think there are any other options except clinical trials. Hopefully the Folfiri will work for her.

    -Sheri

    Sheri
    Sheri, thanks for your response. I'll be praying for you while I keep lifting my mom up in prayers!
  • trish07
    trish07 Member Posts: 138
    #4
    Same thing with my husband.
    Same thing with my husband. He did 6 treatments of Folfox (only one dose of Avastin due to severe side effect) only kept things stable with no shrinkage. He will be trying the Folfiri at the end of this month and is also KRAS-mutant.

    I have asked this question before and the replys were clinical trials.

    Please let me know about your moms follow-up scan and any information you get as to what might be next.

    I do most of my posting on the caregiver site, I will also let you know what our oncologist says about what we will try after the Folfiri if there is no change.

    Trish
  • John23
    John23 Member Posts: 2,122 Member
    #5
    Worthwhile read

    It's worth a read: http://csn.cancer.org/node/178747
  • jillpls
    jillpls Member Posts: 238
    #6
    clinical trial
    HI, I did the full folfox, then folfiri with Avastin. Each time it kept it at bay for about a year. I was told I could go back on either regimen but instead I'm starting a clinical trial at UCSF on Monday. Hopefully this will shrink or keep it at bay.
  • dianetavegia
    dianetavegia Member Posts: 1,942 Member
    #7
    Stable isn't BAD news
    KRAS mutant tumors do not respond to 2 drugs (one family of drugs) but a study is being done, giving Erbitux to KRAS mutants along with another med to see if that allows the Erbitux to work.

    Four treatments is not a whole lot out of 12.
  • califsue
    califsue Member Posts: 80
    #8
    jillpls said:

    clinical trial
    HI, I did the full folfox, then folfiri with Avastin. Each time it kept it at bay for about a year. I was told I could go back on either regimen but instead I'm starting a clinical trial at UCSF on Monday. Hopefully this will shrink or keep it at bay.

    Hi jillpls
    Can you give me the name/number of the trial. Any why you chose it. I am currently looking for a trial and could go to one in the UCSF area. If have been looking through all the trials listed at clinicaltials.gov. If you would like you can PM me with the information.

    Thank you very much,
    Susan
  • KFen725
    KFen725 Member Posts: 108 Member
    #9
    trish07 said:

    Same thing with my husband.
    Same thing with my husband. He did 6 treatments of Folfox (only one dose of Avastin due to severe side effect) only kept things stable with no shrinkage. He will be trying the Folfiri at the end of this month and is also KRAS-mutant.

    I have asked this question before and the replys were clinical trials.

    Please let me know about your moms follow-up scan and any information you get as to what might be next.

    I do most of my posting on the caregiver site, I will also let you know what our oncologist says about what we will try after the Folfiri if there is no change.

    Trish

    Trish
    Trish, I will definitely keep you posted on what happens. Her next scan (the first with Folfiri) is in a few weeks. Thanks for writing!
  • KFen725
    KFen725 Member Posts: 108 Member
    #10
    jillpls said:

    clinical trial
    HI, I did the full folfox, then folfiri with Avastin. Each time it kept it at bay for about a year. I was told I could go back on either regimen but instead I'm starting a clinical trial at UCSF on Monday. Hopefully this will shrink or keep it at bay.

    I hope so too!
    I wish you well with this clinical trial! Let us know how it goes!
  • KFen725
    KFen725 Member Posts: 108 Member
    #11
    dianetavegia said:

    Stable isn't BAD news
    KRAS mutant tumors do not respond to 2 drugs (one family of drugs) but a study is being done, giving Erbitux to KRAS mutants along with another med to see if that allows the Erbitux to work.

    Four treatments is not a whole lot out of 12.

    Diane
    Diane, you are right - stable isn't BAD, but the oncologist was not happy with the results at all.

    We just keep praying for God to heal her. If you would, please keep my mom in your prayers, too :) Thanks!
  • dianetavegia
    dianetavegia Member Posts: 1,942 Member
    #12
    KFen725 said:

    Diane
    Diane, you are right - stable isn't BAD, but the oncologist was not happy with the results at all.

    We just keep praying for God to heal her. If you would, please keep my mom in your prayers, too :) Thanks!

    PRAYING
    I sure will.
  • KFen725
    KFen725 Member Posts: 108 Member
    #13
    dianetavegia said:

    PRAYING
    I sure will.

    Thank you :)
    :)
  • jillpls
    jillpls Member Posts: 238
    #14
    califsue said:

    Hi jillpls
    Can you give me the name/number of the trial. Any why you chose it. I am currently looking for a trial and could go to one in the UCSF area. If have been looking through all the trials listed at clinicaltials.gov. If you would like you can PM me with the information.

    Thank you very much,
    Susan

    not doing a clinical trial after all
    HI,
    I was going to do a clinical trial at UCSF but Blue Cross denied it. So my onc put me on folfox with avastin but again Blue cross denied it. They said I can't have Avastin because I had progression on Xeloda with Avastin. So I"m just taking Folfox and fighting the insurance.
    Jill

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