New treatment strategy

lisa42 said:

exciting news
John,

This is exciting news- thanks for sharing it with us! I'm printing out what you wrote and taking into my oncologist's appt. I just made an appt w/ him for this Wed. I'm going to discuss my plans of going to see Dr. Cantrell in Nashville, but also want to have other info with me, as well. I'm sure you'll let us know how things go for you- it's so great to gain hope with new treatment possibilities!

Lisa

positivenergy said:

CARISDX.com? Diagnosed in May 08 with UPSC, now tumors in Liver
My mother is 65, and was diagnosed in May 2008 with UPSC: uterine papillary serous carcinoma, stage 1C. In June 2009, we discovered it spread to her liver and she has multiple tumors. So far she had a total hysterecrtomy in May 2008, June-Oct 2008 6 treatments of Chemo Carboplatin 1hr & Paclitaxel 3hrs and then a second round of chemo June-Oct 2009, Carboplatin 50mg & Doxorubicin 10mg. A few weeks ago, just before the 6th treatment of chemo, an mri showed that the cancer had become immune to the chemo and that the tumors were growing again. We were sent to a top liver specialist at mt sinai the next week who could not offer surgery but suggested RadioEmbolization SIR Spheres (selected internal radiation). She will have a mock procedure done next week on November 17, 2009. If successful, they will do procedure just after thanksgiving. Her oncologist is also thinking about giving her weekly injections of Tobotokin. Has anyone had success with RadioEmbolization? Tobotikan? Avistan (which we may consider if weget approval)? I also had a friend who is a top pancreatic doctor in NY who recommended Carisdx.com but when I discussed with our oncologist they were not quick to agree. They said we would need to arrange shipment of cancer tissue. Has anyone done this? How do I arrange shipment? I am thinking we might request that they take some new cancer tissue during cat scan when they do the radioembolization. Thank you in advance for any advise on how to arrange shipment and if you suggest it is worth trying caris.

My mother's history: After abnormal bleeding in May 2008, my mother, who is 65 and very healthy, was diagnosed with UPSC: Uterine Papillary Serous Carcinoma, Stage 1C. Although is was a very rare endometrial cancer, the pathological test was clean and the cancer had not broken the line of uterus. She immediately had a total Hysterectomy by lyposcopic surgery and began chemotherapy from late June 2008-October 2008 Carboplatin 1hr, Paclitaxel 3 hrs, every 3 weeks for 6 treatments. In Nov 2008 her PT scan looked clean. The doctor told us there was a 5% chance the cancer would come back. 6 months later in early June 2009, she started to have pain and on June 24, 2009 her PT Scan confirmed multiple hypermetabolic lesions throughout the liver, increased activity within the left iliac bone, suspicious for bone metastic lesion.

She immediately began a second round of chemo from June 29-October 2, 2009 of Carboplatin 50mg & Doxorubicin 10mg. In early October 2009, just before her 4th treatment, her blood level, which had steadily been falling, shot up from 800 to 2000. She began to also have pains on the side but her doctor still gave her the 5th treatment. Just before her 6th treatment, on October 20, 2009, her blood level was still high so her doctor did an MRI that showed the cancer was growing again and had become immune to chemo. He postponed her 6th treatment that was scheduled for October 23, 2009 and we were sent to a liver specialist the next week who did not see surgery as an option but suggested RadioEmbolization Sir Spheres (Selected Internal Radiation) with Nuclear Medicine. The insurance just approved it and she will have the mock procedure done on Tuesday, November 17, 2009. If it is a scucess, she will have the procedure done jsut after thanksgiving. Her oncologist is also trying to get approval for Avistan but may start giving her weekly Tobotikan. Has anyone had success with Radioembolization for liver cancer? Tobotikan? Caris?