There are 4 of us on the CSN Discussion Boards that have UPSC (Uterine Papillary Serous Carcinoma), a rare type of aggressive high-reoccurance endometrial cancer that has much more in common with ovarian cancer than with the more common type of uterine cancer. We post under the "Gynecologic Cancers Other than Ovarian" Discussion Board, but all 4 of us lurk here often to read your posts, as our prognosis and treatment is so similar to yours. One of our 'UPSC-sisterhood-of-4' has been offered a clinical trail that includes Avastin in with her chemo regime. (They are trying to get Avastin FDA-apporval for UPSC treatment.) I was hoping some of you who have taken Avastin could comment on the side effects and efficacy of adding this drug to your chemo. It's being used for lung cancer, and I understand recently used for ovarian cancer. With UPSC, if you can make it a year without reoccurance, you have a good shot of getting out clean. But if it reoccurs even once, the prognosis is very poor. So we're pretty desparate to let them do just about anything to us to prevent reoccurance. Thanks for any input. Feel free to pop into the 'Gynecologic Cancers Other than Ovarian' and post on our UPSC thread we have going there. 3 of us are in current treatment (1 having radiation, 2 of us having chemo) and we have one 2-year survivor providing us with hope.