My dad is stage iv since 12/05. He has been on folfox 4 + Avastin he had to stop because of neuropathy. It was working very well. Went to Xeloda & Avastin and 4 months CEA began climbing. Nov. 06 Folfuri (Vectibix) it was working but had to stop because the rash was so bad. April 07 Erbitux/Camptosar failed. Now we are back on Folfox and it worked after 2 cycles now his CEA is going back up. Doctor says he will be given 2 more rounds and if the CEA goes up they will do a CAT scan to see if there is progression. He also said we are running out of options that we have already recycled the chemo and that I should prepare myself. I just can't accept that. How could the Folfox work the first time and not now and how can we be out of options. Does anyone have any help or advice for us?