Lapatinib GW57016

SusanAnne
SusanAnne Member Posts: 245
edited March 2014 in Breast Cancer #1
Was reading about Lapatinib recently (I'm her2+) and wondered if anyone is participating in any of it's clinical trials. Hopefully I'll never need it, but I'm always trying to stay on top of things that might affect me in the future. It sounds promising. Anyone know anything about it?
Susan

Comments

  • jeancmici
    jeancmici Member Posts: 665 Member
    #2
    Haven't heard of it Susan and tried google exactly as you wrote it and got no entries. Where did you see info about it?
  • EllenM6246
    EllenM6246 Member Posts: 27
    #3
    Good Morning, I went to BCmets.org and typed in lapatinib and found an extensive posting by Musa Mayer about this drug. The clinical trial number is actually GW572016. You can also find a lot of info about clinical trials at www.clinicaltrials.com. Hope this is helpful. Ellen
  • inkblot
    inkblot Member Posts: 698 Member
    #4
    jeancmici said:

    Haven't heard of it Susan and tried google exactly as you wrote it and got no entries. Where did you see info about it?

    Hi Jean:

    There are quite a few entries about this trial on google. You must type in: Cancer Trail GW572016.
    This drug is also being used in lung cancer trials, among others. The majority of the trials are in Calif. but a few in other states. Trial info will provide contact numbers and state, etc..

    Basics are: This is enzyme inhibitor therapy.

    Only 40-80 patients will be participate in the trial. I assume this to mean 40-80 per location.

    Only for Stages IIIB and IV. MUST be documented Her2/neu positive and have received at least 6 cycles of Herceptin and chemo.

    General trial exclusions apply: gastrointestinal, other poor health problems, including severe cardiovascular disease. Participants must have Cardiac Ejection Fraction of at least 55%.

    Let me know if you still cannot get all the "skinny" and I'll email you the details.

    Love, light and laughter,
    Ink
  • SusanAnne
    SusanAnne Member Posts: 245
    #5
    jeancmici said:

    Haven't heard of it Susan and tried google exactly as you wrote it and got no entries. Where did you see info about it?

    Sorry about the typo Jean, I left out the 2. I think the best part about this drug is that it's a PILL!
    Susan
  • jeancmici
    jeancmici Member Posts: 665 Member
    #6
    inkblot said:

    Hi Jean:

    There are quite a few entries about this trial on google. You must type in: Cancer Trail GW572016.
    This drug is also being used in lung cancer trials, among others. The majority of the trials are in Calif. but a few in other states. Trial info will provide contact numbers and state, etc..

    Basics are: This is enzyme inhibitor therapy.

    Only 40-80 patients will be participate in the trial. I assume this to mean 40-80 per location.

    Only for Stages IIIB and IV. MUST be documented Her2/neu positive and have received at least 6 cycles of Herceptin and chemo.

    General trial exclusions apply: gastrointestinal, other poor health problems, including severe cardiovascular disease. Participants must have Cardiac Ejection Fraction of at least 55%.

    Let me know if you still cannot get all the "skinny" and I'll email you the details.

    Love, light and laughter,
    Ink

    >>General trial exclusions apply: gastrointestinal, other poor health problems, including severe cardiovascular disease. Participants must have Cardiac Ejection Fraction of at least 55%.

    Let me know if you still cannot get all the "skinny" and I'll email you the details.
    ~~~~~~~~~~~~~~~~
    Not for me - EF was 20 when I had echogram 5/24- and my health is poor all around. One example is that I obviously did not have the energy to research this thoroughly when FIRST and only attempt failed. You gals know that was not my usual style - but I tire so quickly now.

    What a great crew we have on this forum for good research and common sense and helpfulness.
    Love to all,
    Jean
  • MrTangerineMan
    MrTangerineMan Member Posts: 4
    #7
    Hi Susan,

    My partner has been on GW572016 for 10 weeks now. When she started the trial she had a tumour in her lung measuring 19mm, plus extensive skin mets (rash) on the whole of her left arm (which has lymphoedema), her left hand, her left shoulder, plus patches dotted around her back and stomach. The tumour and rash had been reduced with previous rounds of Chemotherapy (6 x AC, 5 x Taxotir, 6 x Xeloda) over the last two and a half years, but always eventually returned meaning a different approach needed to be tried. Although her initial breast tumour removed was tested and found to be her2+, after 28 weeks of Herceptin, that was also failing to keep the cancer at bay.
    And so now she is on the new (we pray) wonderdrug GW572016. Initial response is very positive. The skin mets I described have very nearly all disappeared. The difference is phenomenal. Her oncologist and clinical trial nurse could barely contain their delight when they compared them to the photographs taken at the start of the trial. The scan on her lung tumour showed that it has not grown at all but is the same size at 19mm. If GW572016 can keep it at this size we would be delighted, as she is in reasonably good health and could certainly live with that. To be honest I was slightly disappointed at the scan result. Having seen the difference in the skin mets, I was hoping the lung tumour would have started to shrink, but maybe that was hoping for too much after 8 weeks. We'll be going for another CT scan in 6 weeks time, so i'll keep anyone who's interested posted on the results.
    Side effects have been minimal (a spotty nose!!!)

    Hope this helps and let me know if there's anything else you need to know.

    Anthony
  • SusanAnne
    SusanAnne Member Posts: 245
    #8
    MrTangerineMan said:

    Hi Susan,

    My partner has been on GW572016 for 10 weeks now. When she started the trial she had a tumour in her lung measuring 19mm, plus extensive skin mets (rash) on the whole of her left arm (which has lymphoedema), her left hand, her left shoulder, plus patches dotted around her back and stomach. The tumour and rash had been reduced with previous rounds of Chemotherapy (6 x AC, 5 x Taxotir, 6 x Xeloda) over the last two and a half years, but always eventually returned meaning a different approach needed to be tried. Although her initial breast tumour removed was tested and found to be her2+, after 28 weeks of Herceptin, that was also failing to keep the cancer at bay.
    And so now she is on the new (we pray) wonderdrug GW572016. Initial response is very positive. The skin mets I described have very nearly all disappeared. The difference is phenomenal. Her oncologist and clinical trial nurse could barely contain their delight when they compared them to the photographs taken at the start of the trial. The scan on her lung tumour showed that it has not grown at all but is the same size at 19mm. If GW572016 can keep it at this size we would be delighted, as she is in reasonably good health and could certainly live with that. To be honest I was slightly disappointed at the scan result. Having seen the difference in the skin mets, I was hoping the lung tumour would have started to shrink, but maybe that was hoping for too much after 8 weeks. We'll be going for another CT scan in 6 weeks time, so i'll keep anyone who's interested posted on the results.
    Side effects have been minimal (a spotty nose!!!)

    Hope this helps and let me know if there's anything else you need to know.

    Anthony

    Hi Anthony. I had pretty much given up hope of finding someone on this drug. I asked my onc. about it last week and he didn't seem to know about it, which kinda disappointed me. I'm glad to hear that your partner is doing well on it. Please keep me posted (susanp@optonline.net). I am in a trial testing herceptin for earlier stages of bc. I'm not sure if I would have to be treated again with herceptin should it return, or if I could skip right to the lapatinib. My last treatment is tomorrow (52 wks in all) so I'm on the lookout already for the next treatment trying to stay abreast (no pun intended). I wish you both well.
    Susan

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