Need some help for my husband

Welcome to the boards. I am 9th Year Stage IV. I started on FOLFOX, then FOLFORI w/Avastin. ( I was in one trial between FOLFOX and FOLFORI but it did not work).

I went on Lonsurf with a bit of trepidation. Like all these drugs people react differently. But Lonsurf was pretty easy for me and shrunk my tumors a bit - about 5% - and stayed on almost a year. Got into a couple of more trials, not much success. Had my cancer grow crazy the start of 2022. Had surgery, radiation and into my forth drug trial. Which has been working since July 2022. Tumors stable or shrinking. One tumor needed radiation last month, but overall doing well.

So give Lonsurf a shot but also keep an eye out for drug trials - search on NHI site. Also get testing done like Foundation One which looks at mutations an other things in the cancer and what treatments work or trials targeting a mutation etc. (note many places do this testing. I am at MSK and try do it. But I had the Foundation One test done 6 years later. Tumors can change).

if cancer is somewhat stable - meaning though some popping up none are a high level threat - perhaps getting into a trial may be the way to go since Lonsurf is still possible.

And I am 49.