Verzenio + aromatase inhibitor for recurrent ER+ endo cancer

The results of a trial were posted recently, thought I'd share.

"A combination therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in 75% of patients with recurrent or persistent estrogen receptor- (ER-) positive endometrial cancer, results from a recent clinical trial show."

...

"Analysis of patients’ tumor tissue showed that responses to the regimen occurred regardless of a tumor’s grade (how abnormal its cells look under a microscope), prior treatment with hormonal therapy, or the presence or absence of progesterone receptors on tumor cells. All patients whose tumor cells harbored mutations in the KRAS, CTNNB1 or CDK2NA genes responded to the therapy, while those whose tumors had TP53 mutations were less likely to respond."

Drug combination shows effectiveness in patients with recurrent ER-positive endometrial cancer