TACE ahead of us

Real Tar Heel said:

There is a big money push

There is a big money push behind mRNA-based targeting therapies for kRAS mutations. I don't know if that means as an add-on to chemo or something completely separate, but search for Merck and Moderna partnering on the research. Add that to the researcher who pioneered the COVID vaccine for them saying they were a couple of years away from a cancer vaccine, there is some hope out there. To me, chemo is just like amputation or leeching, but it is what we have right now. Cancer fight will be empowered by knowledge of what really causes things.

When I was a 3L in law school, my brother was in his final days as an AIDS patient. It was impossible to focus even though I acted like I was participating, I was not really all there (but I'm easily distracted anyway, lol). Don't be too hard on yourself as you are trying to accomplish something important. You will be of value to a lot of people someday.

btw: my aunt and mom have found out about TACE and are asking me to look into it as you did.

The goal is such a specific drug that will probably only work on the cancer in the persons body and for no one else. 

I do hope that the mRNA technologywill give us a big step in medicine. I read a few articles in the next weeks how this covid vaccine will influence the big pharma companies to invest, to compete against each other. For now there were this 2 big companies, moderna and biontech, and biontech recently proved in mouse models that themRNA technology could also help in MS so that the mistaken immune system relearns that the nerbous tissue is not bad. The oncology due to the success of the mRNA vaccines will only get a boost. I like to think that when I retire from my job everything I learned will be so outdated. Maybe cancer will be like hypertension, dsily a pill, some scans and then you just live your life? But then we will have other diseases. 

Thank you for your words! This week is especially hard: onco with my dad, studying onco and in class we have children with cancer. All bad! But HIV is a good example of medical progress in the last decades. Yes it is not curable bitnowdays due to the new drugs you can sleep with someone unprotected and still not infect this person. 

I dont want to push you into this direction but the approach: we treat the liver regionally and if it spreads we will do systemic chemo might not be bad. So yeah ask why it is not an option or where you can do it. Asking is not a bad thing.

worriedson714 said:

fingers crossed

Sounds like so far things went the best the could have so happy for you tueffel

It is 5am here and I just found the negative studies on pubmed... But yes I hope that imagining will show that the tumor really got his a*** kicked. I also hope that his liver markers will get better soon, so I have less to worry. But for now we wait and see how it worked. Fingers are crossed...

Real Tar Heel said:

sounds great!

sounds great!

We will see later how and if it worked. But with my professor words I was afraid that they wont do it, or that they cant do it. But the procedure did happen and now the decrease supply and chemo need to do their work. Unfortunately, I only found bad studies about TACE today. During the weekend I found all the good ones, now I am afraid like usual. 

But I do hope! And it is nice to hear that a doctor sounds confident 

I hoped that during todays imagining you could already see how the tumor looks like now. But they only checked if there is bleeding or not. Papa has the typical metallic taste of chemo in the mouth. He feels good and is home now.

In a month 30th May, they will do a bunch of small ones. They are close to each other so they hope its one artery.

I do hope that everything went well and the tumor is shrinking now. 

The doctors called. Because the tumor is a fast growing tumor they dont want to do the next TACE at the end of May. They want to get ahead of the cancer because they dont know how the situation might be in 30 days. So the next TACE for the next tumors is scheduled on Thursday already. Papa is fine with it. They can help him. The symptoms of chemo disappeared on Sunday already. They also want to discuss another additional therapy. Papa called it gene therapy, no idea what he means with it. Maybe monoclonal antibodies? 

I hope the next one will go well and we might see some results soon. 

PS Tomorrow on Tuesday is my oncomogy exam. Cross your fingers that I am done with it. On some days last week I had to study onco, researched Papas condition and had classes in pediatric oncology. Hopefully one is over soon. 

Papas oncologist talked today to Papa. During the first TACE and the CT the number of liver metastases increased, with the fact that the tumor is only in the liver,they dont feel confident at the moment. They basically dont know what kind of tumor they are treating because it does grow too fast (even for KRAS) I assume and it does nlt act like a colon cancer they know. So Papa signed a bunch of papers, tomorrow they will do a biopsy during TACE, they will grow tumor cells in lab at Roche (?). They are rechecking everything they know because so many things dont fit the initial diagnosis anymore. 

Papa has no problem to "donate" his tumir to science especially if it might help me and my sister. They will check with several collegues in Germany, experts also, if they have an idea. I am afraid now that the tumor will grow to fast that he might not be there till July when I am done with university. Papa feels good of course the news took him mentally down but he is eating good etc. He want to try everything, trials etc, and we will see how and if it will help. 

NewHere said:

Thoughts With You and Your Dad

I am sorry to read about the news Tueffel, and hoping that the biopsy and testing helps.  

Here is a trial https://clinicaltrials.gov/ct2/show/NCT04166435  

Perhaps they can test for this and take a look at the drug combination where your Dad is being treated?  25-40% of people have this.  The drugs are successful for brain tumors and then has been expanded.  It seems that it works on other cancers with this.  

 

It is an up and down here. Last week I was in good mood but the cancer thinks otherwise. This cancer is so strange, something mist be wrong somewhere. 

I do appreciate that the doctors are not giving up and try their best but hearing that even the doctors dont really know why the cancer acts strange is scary. I hope they will find an answer or find something that helps. But I am just afraid now. I was always sure that my dad will be there in July when I come home, now I am afraid I wont have it. 

I remember this drug in studying for oncology. I dont know what the doctors plan. I think atm they are just trying to answer questions. It is frustrating.

worriedson714 said:

no words

So sorry to hear this tueffel sending prayers your and your dad's way hopefully they figure out this tumor . 

Atm the tumor is smarter than the doctors. I hope they find something that might help. I cant do more than that atm which is frustrating