New Research: for Nancy & others with alleric reaction to carboplatin & other chemo drugs

thanks
I know I was already on a 'desensitized' rate of infusion and of course I had pre-meds. I am not sure how long my infusion was scheduled for. I did ask about getting it again over a longer period of time etc. etc. Doc said he wouldnt do it at this time. Wants to try other things first.

For anyone who is interested MSKCC is doing a Carbo desensitized rate trial. If you already had an allergic reaction you do not qualify. GO FIGURE!!!! here is the protocol:


Full Title :
STANDARD INFUSION CARBOPLATIN VERSUS PROPHYLACTIC EXTENDED INFUSION CARBOPLATIN IN THE TREATMENT OF PATIENTS WITH RECURRENT, PLATINUM-SENSITIVE, OVARY, FALLOPIAN TUBE, AND PRIMARY PERITONEAL CANCER
Purpose :
Patients who have recurrent ovarian, fallopian tube, or peritoneal cancer are often treated with several drugs. Carboplatin is one that seems to work for many treatment cycles. Even though it may work against the cancer, patients can become allergic to it. If that happens, treatment with the drug usually needs to be stopped.

Some patients have received carboplatin over three hours instead of 30 minutes. They had fewer allergic reactions than expected. Doctors do not know if this was because of the way they got carboplatin or because of some other factor.

The purpose of this study is to see if giving carboplatin over three hours prevents allergic reactions to the drug, and to see if giving certain other medications before the carboplatin can help reduce allergies. Some patients may receive other chemotherapy drugs as part of their treatment in addition to carboplatin.

Eligibility :
To be eligible for this study, patients must meet several criteria, including but not limited to the following:

Patients must have ovarian, fallopian tube, or peritoneal cancer that has recurred following one or two regimens of prior platinum-based chemotherapy.
Disease must have relapsed six or more months following completion of platinum-based therapy.
Patients who had a prior allergic reaction to carboplatin or cisplatin may not participate.
Patients must be able to be ambulatory for more than half of their normal waking hours.
Patients must be age 21 or older.
For more information about this study and to inquire about eligibility, please contact Dr. Roisin O'Cearbhaill at 212-639-4820.

nancy591 said:

thanks
I know I was already on a 'desensitized' rate of infusion and of course I had pre-meds. I am not sure how long my infusion was scheduled for. I did ask about getting it again over a longer period of time etc. etc. Doc said he wouldnt do it at this time. Wants to try other things first.

For anyone who is interested MSKCC is doing a Carbo desensitized rate trial. If you already had an allergic reaction you do not qualify. GO FIGURE!!!! here is the protocol:


Full Title :
STANDARD INFUSION CARBOPLATIN VERSUS PROPHYLACTIC EXTENDED INFUSION CARBOPLATIN IN THE TREATMENT OF PATIENTS WITH RECURRENT, PLATINUM-SENSITIVE, OVARY, FALLOPIAN TUBE, AND PRIMARY PERITONEAL CANCER
Purpose :
Patients who have recurrent ovarian, fallopian tube, or peritoneal cancer are often treated with several drugs. Carboplatin is one that seems to work for many treatment cycles. Even though it may work against the cancer, patients can become allergic to it. If that happens, treatment with the drug usually needs to be stopped.

Some patients have received carboplatin over three hours instead of 30 minutes. They had fewer allergic reactions than expected. Doctors do not know if this was because of the way they got carboplatin or because of some other factor.

The purpose of this study is to see if giving carboplatin over three hours prevents allergic reactions to the drug, and to see if giving certain other medications before the carboplatin can help reduce allergies. Some patients may receive other chemotherapy drugs as part of their treatment in addition to carboplatin.

Eligibility :
To be eligible for this study, patients must meet several criteria, including but not limited to the following:

Patients must have ovarian, fallopian tube, or peritoneal cancer that has recurred following one or two regimens of prior platinum-based chemotherapy.
Disease must have relapsed six or more months following completion of platinum-based therapy.
Patients who had a prior allergic reaction to carboplatin or cisplatin may not participate.
Patients must be able to be ambulatory for more than half of their normal waking hours.
Patients must be age 21 or older.
For more information about this study and to inquire about eligibility, please contact Dr. Roisin O'Cearbhaill at 212-639-4820.

dubble post- sorry
goofed

nancy591 said:

alleric reaction
Because the risk of reaction increase with every additional infusion. I was told that most people start having alleric reactions after the 8th infusion. So the whole purpose of this study is to start with the slow infusion right for the start. Or if you already exceeded a higher number of infusions and are at an increased risk of allergic reactions you can/should start receiving at a slower infusion rate. They are studying to see if going at a very slow rate will cut down on alleric reactions.

When I restart carbo after a year of being off of it I was started at a desensitized rate WITHOUT any history of problems. That is MSKCC standard protocol. Anything over 8 rounds is given slowly. I am not sure what the rate of infusion was but I had an allergic reaction at the completion of my 10th infusion. Bummer for me because the drop in the ca125 was the greatest I had since restarting chemo earlier that year. My reaction was not bad, in my opinion, and I'd be willing to try it again at a SLOWER rate with more pre-meds. Doc wants to wait on that and try other things first.

How many infusions have you had total to date?

Great info
As always you have great info, Nancy. I have had 11 infusions total.(8 with the first series, 3 with this) I'm not sure if I didn't get a desensitized rate at the start of my last series. They did say the first infusion would take longer. Betweeen the carbo and doxil, I was hooked up from 8-4. I'm sure now that's what it was. I will have to pay more attention. My chemo team isn't real forthcoming unless asked! I guess now I need to study infusion rates! LOL
Now I am REALLY apprehensive about the wheel test!
I have been fortunate in that, so far, I have never had to stop a chemo because of a reaction or "bad" labs. I'm hoping it continues.
Thanks so much for the info. It explains a lot.
Ginny