Frustration

Cancer produces symptoms, but symptoms do not necessarily produce cancer. My advice is not to look for a cancer which you do not have. After that much testing that many biopsies and zero cancer being found, it is almost 100% certain not to be a malignancy. There are 68,069 known diseases and many times that which are unknown. There are millions of viruses. Millions. Only about 3,300 of them are identified. 2019 in my experience, has been a year filled with unknown viruses. I just finsihed my 6th or 7th for the year. Only the last one was identified as the common rhinovirus. 

The reactive nodes mean that your immune system is reacting to something, but what? Have you have a blood panel run for allergies? I just did and received some surprisong results. If no malignancy is found, immune response is immune response. With so many thousands of conditons to check, no wonder it takes some extended diagnostics to arrive at an answer. But, also be aware that many diseases and conditions are never identified, and so only the symptoms can be addressed. Wondering if you have been to an endocrinologist?

kfit,

Very few things produce night sweats:  blood cancers, and menopause.  That's about it.  Before diagnosis, my wife had me sleeping on a beach blanket and a body towel.  They were soppy each morning.  We did not know what that meant, especially since I've always been a heavy sweater during the day (completely unrelated to night sweats, we now know).  The night sweats, severe fatigue, and enlarged nodes are DAMN suspicious, IM (not usually) HO.   It is the textbook presentation of what are termed "B-Symptoms."

 Obviously, you are waay too young for age-related menopause.  If no blood cancer can be identified and this continues, see a Gyn had have your ovaries tested.   Even men with prostate cancer, if they have to go on hormonal therapy (known as "Chemical Castration") at times report night sweats, since they are in effect experiencing a drug-induced 'menopause.'

Your severe fatigue is classic, and almost nothing causes nodular pain after alcohol consumpion.  One of the few documented causes is as a RARE reaction to Hodgkin's type Lymphoma.  This is not a common thing, but remarkable when it occures.    I have this pain today, ten years after total remission from HL, after a few beers.

Like Shady, I would suggest seeing a bona fide (Board Certified) Hematologist.  Board Certification in Hematology is a seperate, different certification than 'Medical Onlology,' although they overlap a lot, and many doctors hold BOTH.   (I personally have never read the credentials of a hematologist who was not also a Medical Oncologist, but most medical oncologists are not Board Certified in Hematology, although they often treat blood cancers.)

Assumedly your biopsies were excise (surgically cut out, NOT pulled via a needle).   I would also definitely have your biopsy sample sent to a prominent institution for second opinion: some place like Johns Hopkins, MD Anderson, Sloan Kettering, Stanford, Emory University, Mayo Clinic, etc.   You may have to pay out-of-pocket, but I would do it.  Some lymphomas are extremely rare and seldom seen in pathology labs.   It is either a hematological disorder or immuniological issue it seems.   And be aware: No member here is a doctor, and none of us can give medical 'advice' -- just our own insights, and what we would do, based upon reading and personal experience.

My read of your questions,

max