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Does Green Tea help 5FU work better? (abstract only) https://www.ncbi.nlm.nih.gov/pubmed/30741544

Here, we report that EGCG [a chemical in green tea] reinforces the sensitivity of colon cancer cells to 5-FU, and the IC50 values of 5-FU is decreased from 40±4.2 μM to 5±0.36 μM in one human colon carcinoma cell line-HCT-116, and from 150±6.4 μM to 11±0.96 μM in the other human colon carcinoma cell line-DLD1 when these cells are co-treated with 50 μM EGCG. Consistently, compare to 5-FU or EGCG treatment alone, the combination of both significantly promotes cancer cell apoptosis and DNA damage. Further mechanism researches reveal that treatment of colorectal cancer (CRC) with 50 μM EGCG inhibits GRP78 expression, activates NF-κB (2.55±0.05 folds for HCT-116 and 2.27±0.08 folds for DLD1) pathway and enhances miR-155-5p (2.12±0.02 folds for HCT-116 and 2.01±0.01 folds for DLD1) level. The elevated miR-155-5p strongly suppresses target gene MDR1 expression, which blocks the efflux of 5-FU. The accumulation of 5-FU resulted in caspase-3 and PARP activation, Bcl-2 reduction and Bad increase, which ultimately lead to cancer cell apoptosis. Overall, our data shows that EGCG may be act as a novel chemo-sensitizer, and GRP78/NF-κB/miR-155-5p/MDR1 pathway plays vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.

More wine, please (abstract only): https://www.ncbi.nlm.nih.gov/pubmed/30741437

Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing. Resveretrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. The molecular basis for the pleiotropic activities of resveratrol are based on its ability to modulate multiple cell signaling molecules such as cytokines, caspases, matrix metalloproteinases, Wnt, nuclear factor-κB, Notch, 5'-AMP-activated protein kinase, intercellular adhesion molecule, vascular cell adhesion molecule, sirtuin type 1, peroxisome proliferator-activated receptor-γ coactivator 1α, insulin-like growth factor 1, insulin-like growth factor-binding protein 3, Ras association domain family 1α, pAkt, vascular endothelial growth factor, cyclooxygenase 2, nuclear factor erythroid 2 like 2, and Kelch-like ECH-associated protein 1. Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use.

Low carb/veggies the best diet? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350503/

[A] plant-rich, low-carbohydrate diet, which emphasizes plant sources of fat and protein with moderate consumption of animal products, was associated with lower CRC-specific mortality (hazard ratio [HR] comparing extreme quartiles = 0.37, 95% confidence interval [CI] = 0.25 to 0.57, Ptrend < .001). Carbohydrate intake was associated with higher CRC-specific mortality, and this association was restricted to carbohydrate consumed from refined starches and sugars (HR per one-SD increment = 1.36, 95% CI = 1.14 to 1.62, Ptrend < .001). In contrast, replacing carbohydrate with plant fat and protein was associated with lower CRC-specific mortality, with the HR per one-SD increment of 0.81 (95% CI = 0.69 to 0.95, Ptrend = .01) for plant fat and 0.77 (95% CI = 0.62 to 0.95, Ptrend = .02) for plant protein.

Sunshine!  Sunshine!  (abstract only): https://www.ncbi.nlm.nih.gov/pubmed/30739209

UV emission levels showed a strong negative correlation with the incidence of esophageal and gastric cancers, in both genders, in all years. However, this correlation was stronger in men. UV radiation showed a significant correlation with colon cancer among both genders as well. There was no relation between altitude and incidence of cancer. Linear regression results showed that with a unit increase in UV, the incidence of gastric and esophagus cancers in males decreases by β = -4.99 and β = - 3.16 significant coefficients, respectively. Cities with higher levels of UV index have a relatively lower incidence of gastrointestinal cancers. Ultraviolet radiation may act as a protective factor against these cancers.