pain on Votrient

beat me down also. But I had no pain as you describe.

My husband also has stage IV renal cell carcinoma. He had his left kidney removed in July of this year. We were told at that time that he had clear margins. However, we were due to follow with a back doctor due to a previous back injury. He told us that he felt the cancer had spread to his spine, and did a biopsy. This biopsy showed the kidney cancer had indeed spread to his spine and a rib. He started Votrient about 6 weeks ago. My husband hasn't experienced nausea but has most definitely experienced the musculoskeletal pain. We had read that taking it at night might help with side effects. So he first took it on a Friday night, and by the next morning when he woke up he said he could actually feel where the cancer was in his bones. Over the next week the pain and fatigue increased to the point that he could hardly get out of bed despite pain medicatio. After the two week mark the pain seems to have lessened to a more manageable level. It is still there but not so bad that he has to live on pain meds round the clock, just takes it a night. We haven't had the first scan yet but we are hopeful. It's definitely a scary way to live though. So much uncertainty. 

sw.bwgroup said:

Pain on Votrient

My husband also has stage IV renal cell carcinoma. He had his left kidney removed in July of this year. We were told at that time that he had clear margins. However, we were due to follow with a back doctor due to a previous back injury. He told us that he felt the cancer had spread to his spine, and did a biopsy. This biopsy showed the kidney cancer had indeed spread to his spine and a rib. He started Votrient about 6 weeks ago. My husband hasn't experienced nausea but has most definitely experienced the musculoskeletal pain. We had read that taking it at night might help with side effects. So he first took it on a Friday night, and by the next morning when he woke up he said he could actually feel where the cancer was in his bones. Over the next week the pain and fatigue increased to the point that he could hardly get out of bed despite pain medicatio. After the two week mark the pain seems to have lessened to a more manageable level. It is still there but not so bad that he has to live on pain meds round the clock, just takes it a night. We haven't had the first scan yet but we are hopeful. It's definitely a scary way to live though. So much uncertainty. 

I haven't heard the term "clear margins" from any of my health care providers.

Can you explain the term for my education, please?

Thanks.

If this is not the correct thread to discuss Votrient side effects, let me know.

I'm four days into my Votrient treatment. Last night was a bit rough.

I *almost* welcome the diarrhea after two and a half months of the constipation that comes with narcotic pain relievers. Several trips to the bathroom per night, however, will get old very soon with the lack of mobility from my spine met.

I don't have nausea yet, but had to stop taking the protonics that I was perscribed because protonics and Votrient don't mix. The indegestion is pretty bad.

Someone said, in an earlier post, that their husband could feel his tumors. Yeah, I feel that too. I hope it means the Votrient is kicking the tumors' ****.

Footstomper said:

Side Effects

"I *almost* welcome the diarrhea after two and a half months of the constipation that comes with narcotic pain relievers."

I suspect you may come to rue that sentence. Hang on in there, but tell your doc. That seems a bit rough.

Buy flushable moist soothing towelettes. You WILL thank me.

 

Thanks for the advice, Footstomper.

I've been on Votrient for approximately 1 1/2 years now. Started at 600 mg but quickly reduced to 400 mg due to high blood pressure. Just reduced to 200mg this October due to no new growths and no growth on current nodules. I, also had diarrhea very bad! The bad diarrhea didn't start until probably last 3 months. Nausea and diarrhea was tolerable until then. On maintenance for now. New scan in January. No pain with Votrient. Actually very tolerable until recently. Appetite is back and putting on few lbs now instead of loosing weigh. 

Sort of like, "if you keep your hand in water for 10 seconds, does it get more wet than if you put it in for 5 seconds." Ok nothing of the sort.

I was very sick when I started 800mg. Now I forget but I think I had to drop to 400 and it was tolerable for maybe 9 months. But eventually I got too sick from it. Just like I did this time with cabo.

I have started pazopanib for 18 days only. 800 mg per day. No other problem but getting low back pain. I have only skull bone mets. but on scan no spine or pelvic bone mets. Can anybody comment on this?