PARP inhibitors

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Comments

  • Nicm
    Nicm Member Posts: 32 Member
    #22
    LorettaMarshall said:

    "Gypsy"~Hope U get 2 wander around 4 A long time!

    Dear "Gypsy"

    Your letter peaked my interest in the drug Lynparza and I decided to look into its usage.  So I decided to answer you specifically, but I put it on a separate topic so that others might like to read more about Lynparza.  The info I've listed could serve as a starting point for others if their doctors are prescribing it for their particular problem.  So please read my reply at: https://csn.cancer.org/node/309690

    Sure hope your efforts to get help with funding will pay off for you and wishing you every success.  I know that you want to wage war against this cancer as long as you are physically able, as we all do.

    Loretta

    Thank you Loretta! Sure does

    Thank you Loretta! Sure does give me a lot to look into! My best to you!

  • Blue J
    Blue J Member Posts: 2
    #23
    Lynparza

    I have been taking Lynparza for 3 years. It saved my life. I couldn't stand the chemo anymore. The side effects from Lynparza I had at first were fatigue and vomiting. It was miserable for awhile but went away. I have had some great days and a lot of not so great days but Lynparza to me is so much better than Chemo.

  • chemonotsobad
    chemonotsobad Member Posts: 1
    #24
    Zejula Experience

    I realize this thread is a little older, but just in case more people come in trying to find out more Info on taking Zejula.  I've been on it for almost 2 months.

    Most of the various side effects came and went within the first 3 weeks.  I had little nausea, some "fullness/bloated" feeling.  I take Miralax to avoid constipation (that was causing the bloated feeling).  A couple days I ran a temp. I perhaps feel a little more tired, but not bad.  I still go to the gym 3 days a week and walk 10k steps most days. I did have a few days of low energy in the first 2 weeks.  

    Side effects that persist are dry mouth, a sore on my tongue (not bad) and I'm not sleeping as well as I'd like. Probably my most severe side effect is a big increase in my heart rate and much higher blood pressure. So this has not gone away so far.   I did test taking the meds in the day, then in the evening.  I feel the best taking them in the evening. So far my CA125 is still rising.  It was about 45 when I started and its up to 95 as of this week.  I'll get a PET scan next month.  My ca125 was 400 when I was originally diagnosed.  It was down to about 13 after chemo, round one. One day at a time..  Based on my experience if your Dr. says you need it, take it.  Hope this  helps someone out there!

  • Sgill709
    Sgill709 Member Posts: 1 Member
    #25
    Lynparza since 12/2016

    Hi I have been in Lynparza since 12/19/2016. For most of 2017 my CA 125 was >2 so basically not measurable. It started to climb slowly in the fall. I noticed 2 lymph nodes but my count was still in the normal range. I went for a second opinion at UVA and the interventional radiologist wanted to do a thermal ablation since the lymph nodes were the only place my stage 3/4 cancer spread. We did it and the lymph nodes are shrinking and my CA125 is going back down to normal. If this does not work, I have more chemo options and an immunotherapy trial I can try. I am into my second year of Lynparza and it is still working for me.

  • NoTimeForCancer
    NoTimeForCancer Member Posts: 3,488 Member
    #26
    thank you all for coming and

    thank you all for coming and sharing your experiences.  I think you all agree how important it is for others to have a place to read about it all.  

    pandagypsy hasn't been on for awhile, so I hope she is just busy taking care of herself.  Prayers for all the warriors.

  • judndav
    judndav Member Posts: 5
    #27
    PARP Inhibitors

    Been studying up on PARP usage, seems they do work especially well for people that are BRCA positive.  The side effects typically get less severe with continued usage. The PFS (time before cancer recurs) is similar across the 3, Lynparza (AZN), Zejula (Tesaro) and Rubraca (Clovis).  15 to 21 months if BRCA positive.

    Don't let those numbers scare you, you are an individual who may fall on the curve out beyond 5 years or further.  Then just go on and fight it again.

    A lady in Portland, Oregon is a 20 year survivor.  She has a blog.  Wiil try to find it and post it for others.

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