Takingcontrol58: Metformin & restoring Progesterone Receptor Status?

https://www.ncbi.nlm.nih.gov/pubmed/21168492

I think this is what you are looking for:

http://www.croh-online.com/article/S1040-8428(16)30139-1/pdf

See section 4 titled "Metformin and endometrial cancer" at the bottom of the 3rd onto the 4th pages.

If pasting the link doesn't work google the title "Metformin use and gynecological cancers: A novel treatment option emerging from drug repositioning" dated June 16, 2016.

Old Beauty,

MAbound quoted a good article I am familiar with. SF73 quoted a good article that I had 
not seen before, which talks about progesterone.  Below is another article to use for
reference:  Remember, metformin does so much more than just lower glucose, but I 
don't think most oncologists know this. And I was not diabetic- I was considered 
pre-diabetic so hopefully I'll never be diabetic while on this drug.  My father died from
complications of Type 2 diabetes.

www.pubmed.gov- PMID22701483 "Metformin, an emerging new therapeutic option for
targeting cancer stem cells and metastasis." June 2012.

I wanted to give you an older article so you can show your onc that they have known about
the anti-cancer benefits of metformin for a long time.  I believe they first discovered them
in 2006. You have to wonder why they have not fast tracked this miraculous drug. I think
it is because it is cheap and it works.

You can tell you onc you know a women who was in the trial he referenced- the trial ends in
Sep 2019, though results don't usually come out much later. You can let him know not 
everyone can wait that long. You can tell him I was in the trial for one month, then removed
myself and got on metformin (the trial is a random trial so I may have been getting the
placebo, and they won't tell me until the trial ends.)  After 3 chemo infusions of Taxol/Carbo
and one month on metformin 30cm of metastatic tumors vanished. It took another five months
to get rid of the remaining 4cm.  Unfortunately, my results won't be part of the trial.  I fear
that the trial may have been set up to fail-  they are testing for 3 mutations popular in EC-I had
one of those mutations. But the women with these mutations were not guaranteed the drug, who
the drug was more likely to help. The mutations were on the Pi3K pathway the most mutated
pathway in EC, and metformin targets this pathway.  I'd be happy to speak with your onc if he
is interested.

I just found a new article the other day at www.pubmed.gov entitled "Metformin and Pancreatic
Cancer Metabolism." On page 167 of the article, there is a great chart mapping out all the pathways
and such that metformin targets, with a detailed explanation of each below the diagram. The diagram
is labeled Figure 3. Metformin impairs signaling molecules for cancer survival.

It doesn't matter that the article talks about pancreatic cancer. Metformin is known to be effective
for all types of cancer- endometrial, ovarian, breast, liver, pancreatic, thyroid, colon, prostate,
melanoma and glioblastoma. Many of these cancers are caused by similar risk factors and common gene mutations.

There is alot of good information in the article on all the pathways that metformin is involved in-
most of these are also affected in endometrial cancer.  Cancer is cancer.  We all have the same organs,
genes, pathways, etc. You'll also get the history of metformin, chemopreventive properties, glucose lowering
properties, anti-lipogenic drug.  It's all these things that metformin does that make it such a miraculous drug for
cancer patients. And if you happen to have some of the health issues andkey mutations metformin targets, I think
you might have miraculous results like I did. It is an ideal targeted therapy if you have a certain
cancer profile.

In the end, you will most likely have to get the drug from your PCP or endocrinologist or integrative
oncologist. It is unfortunate your oncologist is not enlightened. I hope you can enlighten him.

Takingcontrol58

I started taking many antioxidants while I was on the chemo and metformin,
plus starting drinking my daily smoothie, made mostly with berries and the antioxidants.
I still drink this same smoothie to this very day.

He mentions that when the STAT3 gene is turned on, the cancer cells become filled with antioxidants.
But I was on metformin, which turns off the STAT3 gene, so perhaps the antioxidants
weren't in my cancer cells but protected my normal cells from the dangerous effects of chemo.
I only had minor side effects from the chemo and went into total remission.  I think it is the right
combination of a group of treatments that is how you heal cancer.  You have to come at the cancer
from many directions.  Remember, you have many more normal cells to protect than cancer
cells to kill.

Takingcontrol58

Again, my integrative oncologist was a molecular biologist, so I think he may have known all
this when he put me on the metformin and supplements.