New study indicates Melatonin increases the effectiveness of 5FU
A new study (abstract only in link) indicates melatonin increases the effectiveness of 5FU: https://www.ncbi.nlm.nih.gov/pubmed/28819759
Once again, from the "for what it is worth" department, here is additional melatonin information from my rather disorganized notes:
Preliminary positive: 2017 article,
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=16379&path[]=52418
20 mg melatonin plus chemo, improved the complete and partial remission (16.5 vs. 32.6%; RR = 1.95, 95% CI, 1.49-2.54; P < 0.00001) as well as 1-year survival rate (28.4 vs. 52.2%; RR = 1.90; 95% CI, 1.28-2.83; P = 0.001), and dramatically decreased radiochemotherapy-related side effects
https://www.ncbi.nlm.nih.gov/pubmed/22271210
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848957/
Older article, favorable: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198018/
http://journals.sagepub.com/doi/pdf/10.1177/1534735408322846
Statistically insignificant 42% reduction: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814533/
In trials combining MLT with chemotherapy, adjuvant MLT decreased 1-year mortality (RR = 0.60; 95% CI = 0.54-0.67) and improved outcomes of complete response, partial response, and stable disease; pooled RRs were 2.53 (1.36-4.71), 1.70 (1.37-2.12), and 1.15 (1.00-1.33), respectively. In these studies, MLT also significantly reduced asthenia, leucopenia, nausea and vomiting, hypotension, and thrombocytopenia. http://journals.sagepub.com/doi/pdf/10.1177/1534735411425484
Comments
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That's an interesting finding
That's an interesting finding. I wonder if maybe it has something to do with helping a person sleep more. I've been using melatonin off and on and it does the trick on those stressful nights to get some sleep. My dosage has been rather small at 5-10 mg depending on how wound up I am. I'm on radiation and Xelodan which is the pill form of 5FU so it's in the same ballpark.
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Mellow-tonindarcher said:That's an interesting finding
That's an interesting finding. I wonder if maybe it has something to do with helping a person sleep more. I've been using melatonin off and on and it does the trick on those stressful nights to get some sleep. My dosage has been rather small at 5-10 mg depending on how wound up I am. I'm on radiation and Xelodan which is the pill form of 5FU so it's in the same ballpark.
I am on Xeloda/Capecitabine as well. I take 10mg 30 minutes before bedtime and 10mg more the first time I get up at night--generally around 12:30pm. I did build up to the 20mg dosage, but it seems to be helping with both sleep and side effects. The benefit does not seem to be merely the better sleep. I am no scientist, but the colon apparently has a lot of melatonin receptors and the extra melatonin may have some effect on the opportunity for tumors to grow.
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Help with side effectsSandiaBuddy said:Mellow-tonin
I am on Xeloda/Capecitabine as well. I take 10mg 30 minutes before bedtime and 10mg more the first time I get up at night--generally around 12:30pm. I did build up to the 20mg dosage, but it seems to be helping with both sleep and side effects. The benefit does not seem to be merely the better sleep. I am no scientist, but the colon apparently has a lot of melatonin receptors and the extra melatonin may have some effect on the opportunity for tumors to grow.
How did the melatonine help with your side effects specifically? I am definately interested in anything that might give some side effect relief.
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Side effectsPhoenix_66 said:Help with side effects
How did the melatonine help with your side effects specifically? I am definately interested in anything that might give some side effect relief.
I am taking a number of supplements, so I am not certain I can narrow the benefit down to the melatonin, but it reduced the nueropathy and nausea, and seemed to give me more energy. Sorry I cannot be really scientific about it. Probably the best thing to do is clear it with your doctor and try it for a week and see what happens.
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Sounds like a good thing for
Sounds like a good thing for me to take. I am having sleep problems anyway so have some in my cupboard already.
I want to start on the fishoil curcurim soon too - the pills are so darn big though, I don't know if I can swallow them. May try the red krill oil and lood for smaller curcurim pills.
What other supplements do you take?
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other supplementsJoan M said:Sounds like a good thing for
Sounds like a good thing for me to take. I am having sleep problems anyway so have some in my cupboard already.
I want to start on the fishoil curcurim soon too - the pills are so darn big though, I don't know if I can swallow them. May try the red krill oil and lood for smaller curcurim pills.
What other supplements do you take?
I have an older post here: https://csn.cancer.org/node/310395
Hopefully I will have time to update it before too long.
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I bought 500 iu Vitamin D3 +Joan M said:Sounds like a good thing for
Sounds like a good thing for me to take. I am having sleep problems anyway so have some in my cupboard already.
I want to start on the fishoil curcurim soon too - the pills are so darn big though, I don't know if I can swallow them. May try the red krill oil and lood for smaller curcurim pills.
What other supplements do you take?
I bought 500 iu Vitamin D3 + Calcium + Magnesium yesterday and took one today. Also huge pills.
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